The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis

Zhang, Y.-G.; Li, X.-B.; Zhang, J.; Huang, Jingsheng; He, Chao; Tian, Chao; Deng, Yilun; Wan, Hang; Shrestha, Dhan Bahadur; Yang, Yingying; Fan, Hong

doi:10.1111/j.1398-9995.2010.02438.x

Cited by 37 publications

(30 citation statements)

References 27 publications

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“…Davin et al (12) reported that the incidence of increased plasma IgE levels relative to age-matched normal values was significantly higher among HSP patients, indicating that IgE may play a pathogenic role in HSP. IL-5 induces B-cell immunoglobulin class switching to IgA and also activates eosinophils (22)(23)(24). HSP has previously been considered an IgA-mediated vasculitis (1).…”

Section: Hsp In Allergic Diseasesmentioning

confidence: 99%

“…Epidemiological data reveal that the prevalence of Th1-mediated autoimmune diseases has been rising in parallel with Th2-mediated allergic diseases worldwide over the past two decades (21)(22)(23). The hygiene hypothesis suggests that early-life infections and microbial exposures may protect against the development of allergy and autoimmune diseases, as a potential explanation for the increased occurrence of allergic and autoimmune diseases (24)(25)(26). In our previous population-based cohort studies, we found increased incidence and risk of systemic lupus erythematosus (SLE) in children with atopic dermatitis and asthma (27,28).…”

Section: Hsp In Allergic Diseasesmentioning

confidence: 99%

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Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study

et al. 2015

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Background: Some allergic inflammation-associated mediators have been reported in acute stage of HenochSchönlein purpura (HSP). However, the association of children with allergic diseases and their subsequent risks of HSP and HSP nephritis remain unknown. Methods: In this study, we included 2,240 children with HSP diagnosed between 2000 and 2008 as well as 8,960 non-HSP controls matched for age, sex, and level of urbanization. The odds ratios (ORs) of HSP were calculated with respect to associations with pre-existing allergic diseases. results: Children with allergic diseases had an increased subsequent risk of HSP; the lowest adjusted OR (aOR) was 1.33 for allergic conjunctivitis (95% confidence interval (CI): 1.17-1.52) and the highest was 1.68 for asthma (95% CI: 1.48-1.91). The aOR increased to 2.03 (95% CI: 1.80-2.31) in children with at least two allergic diseases. Children who visited medical institutes more often per year for associated allergic diseases had an increased risk of HSP. Of the 2,240 children with HSP, 249 (11%) had HSP nephritis and 45.8% of those with nephritis had history of any allergic disease. conclusion: Atopic children had an increased subsequent risk of HSP but not an increased risk of HSP nephritis. h enoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis that primarily affects children and is characterized by nonthrombocytopenic purpura, abdominal pain and bleeding, arthritis, and renal involvement. Although the clinical course of HSP is generally benign and self-limited (1), renal function impairment, bowel perforation, and central nerve system involvement are rare but cause severe morbidity and long-term complication which need more aggressive treatment (1-3). HSP with renal involvement, HSP nephritis, has been reported to occur in 20-50% of the patients with HSP, and the long-term outcome of HSP depends primarily on the extent of renal involvement (4-7). The manifestations of HSP nephritis vary from asymptomatic hematuria and/or proteinuria to nephritic syndrome, nephrotic syndrome, and rapidly progressive glomerulonephritis (4-7). To date, the exact etiology and pathogenesis of HSP are unknown. However, HSP is regarded as a specific immune-mediated inflammation induced by environmental factors, such as infections and seasonal variation (1,8). Some inflammatory mediators, including tumor necrosis factor (TNF)-α, interleukin-6, IL-8, transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF), and cysteinyl leukotrienes, have been reported to be higher in children with acute HSP than in healthy controls (9-11). Cysteinyl leukotrienes are potent inflammatory mediators which contribute to asthma (12). Elevated Th2-mediated biological markers such as elevated serum IgE, serum eosinophil cationic protein (ECP), and urinary leukotriene E4 levels were found in acute stage of HSP (10-13). The onset of HSP has been reported after exposure to drug or food allergens, vaccines, and insect bites (14-16). In our clinical experience, some children with HS...

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Section: Hsp In Allergic Diseasesmentioning

confidence: 99%

Section: Hsp In Allergic Diseasesmentioning

confidence: 99%

Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study

et al. 2015

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“…Deviation from Hardy-Weinberg equilibrium (HWE) for the distribution of the allele frequencies was analyzed by Fisher exact test in control groups [17]. Odds ratios (ORs) corresponding to a 95% confidence interval (CI) were applied to evaluate the strength of association of VDR polymorphisms with CAD risk; ORs were calculated according to the method of Woolf [18].…”

Section: Methodsmentioning

confidence: 99%

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh¹,

Djafarian²,

Alizadeh

et al. 2017

Lifestyle Genomics

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Background and Aims:ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. Methods: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk. Odds ratios with 95% confidence intervals were calculated to assess the strength of association in the dominant model, recessive model, allelic model, and genotypes contrast. Results: Nine studies involving a total of 5,259 cases and 1,981 controls were finally included in this meta-analysis. Overall, no significant associations were found between ApaI, FokI, TaqI, and BsmI polymorphisms and the risk of CAD in any of the genetic models (all p ˃ 0.05). Moreover, a subgroup analysis by ethnicity did not reveal a significant relationship between any of the examined polymorphisms and CAD risk in Caucasians and East-Asians for any model (all p ˃ 0.05). Conclusion: Current evidence suggests that the ApaI, FokI, TaqI, and BsmI polymorphisms of the VDR gene might not be associated with genetic susceptibility to CAD. Further well-designed studies with large sample sizes are needed to confirm our results.

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“…In addition, PTB is a complex disease that results from the infection with Mycobacterium TB and genetic susceptibility. These differences in genetic susceptibility may also result from individual status or other factors (Zhang et al, 2010). Thus, further studies are needed to assess the effect of additional interactions in different ethnicities and to validate our results.…”

Section: Discussionmentioning

confidence: 99%

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

Shi¹,

Yang²,

Sun³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and Korean populations. To explore the role of the MCP-1 gene in the susceptibility to PTB in a North Chinese population, we evaluated the association between MCP-1 -2518A/G gene polymorphisms and the risk for tuberculosis. Polymerase chain reaction amplification of genomic DNA followed by restriction fragment length polymorphism analysis was used. There was a significant increase in the frequency of the GG genotype of MCP-1 -2518 in 136 patients with PTB compared to that in 152 healthy controls (P = 0.008, c 2 = 7.133, odds ratio = 1.96). Similarly, the frequencies of the A/G alleles in the 2 groups differed; the frequency of allele G was higher in patients with PTB (P = 0.011, c 2 = 6.428, odds ratio = 1.536). In conclusion, the -2518A/G polymorphism in the MCP-1 gene G.L. Shi et al. 4036©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4035-4040 (2015) was found to be associated with an increased susceptibility to PTB in a North Chinese population.

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The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis

Abstract: This meta-analysis suggested that the I/D polymorphism of ACE gene would be a risk factor of asthma. To further evaluate gene-to-gene and gene-to-environment interactions between polymorphisms of ACE gene and asthma risk, more studies with large groups of patients are required.

Cited by 37 publications

References 27 publications

Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study

Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study

Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

MCP-1 gene polymorphisms in North Chinese patients with pulmonary tuberculosis

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