The<i>Drosophila</i>LIN54 homolog Mip120 controls two aspects of oogenesis

Cheng, Mei-Hsin; Andrejka, Laura; Vorster, Paul J.; Hinman, Albert W.; Lipsick, Joseph S.

doi:10.1242/bio.025825

Cited by 5 publications

(3 citation statements)

References 84 publications

(110 reference statements)

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“…The dREAM complex has a well-established role in cell cycle regulation ( Sadasivam and Decaprio, 2013 ). Indeed, Mip120, was recently found to be required for decondensation of nurse cell nuclei ( Cheng et al, 2017 ) and E2F2 is required for endo-replication of follicle cells ( Cayirlioglu et al, 2001 ). We did not observe a role for L(3)mbt in the regulation of nurse and follicle cell endo-replication.…”

Section: Discussionmentioning

confidence: 99%

L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary

2018

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Maintenance of cellular identity is essential for tissue development and homeostasis. At the molecular level, cell identity is determined by the coordinated activation and repression of defined sets of genes. The tumor suppressor L(3)mbt has been shown to secure cellular identity in Drosophila larval brains by repressing germline-specific genes. Here, we interrogate the temporal and spatial requirements for L(3)mbt in the Drosophila ovary, and show that it safeguards the integrity of both somatic and germline tissues. l(3)mbt mutant ovaries exhibit multiple developmental defects, which we find to be largely caused by the inappropriate expression of a single gene, nanos, a key regulator of germline fate, in the somatic ovarian cells. In the female germline, we find that L(3)mbt represses testis-specific and neuronal genes. At the molecular level, we show that L(3)mbt function in the ovary is mediated through its co-factor Lint-1 but independently of the dREAM complex. Together, our work uncovers a more complex role for L(3)mbt than previously understood and demonstrates that L(3)mbt secures tissue identity by preventing the simultaneous expression of original identity markers and tissue-specific misexpression signatures.

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Section: Discussionmentioning

confidence: 99%

L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary

2018

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“…The dREAM complex has a well-established role in cell-cycle regulation (Sadasivam and Decaprio 2013). Indeed, Mip120, a core dREAM component, was recently found to be required for decondensation of nurse cell nuclei (Cheng et al, 2017) and E2F2 is required for endo-replication of follicle cells (Cayirlioglu et al, 2001). We did not observe a role for l(3)mbt in the regulation of nurse and follicle cell endo-replication.…”

Section: Discussionmentioning

confidence: 99%

L(3)mbt and the LINT complex safeguard tissue identity in the Drosophila ovary

Coux

Teixeira

Lehmann

2017

Preprint

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Maintenance of cellular identity is essential for tissue development and homeostasis. At the molecular level, cell identity is determined by the coordinated activation and repression of defined sets of genes. Defects in the maintenance of the genetic programs required for identity can have dire consequences such as organ malformation and cancer. The tumor suppressor L(3)mbt was shown to secure cellular identity in Drosophila larval brains by repressing germline-specific genes. Here we interrogate the temporal and spatial requirements for L(3)mbt in the Drosophila ovary, and show that it safeguards the integrity of both somatic and germline tissues. L(3)mbt mutant ovaries exhibit multiple developmental defects, which we find to be largely caused by the inappropriate expression of a single gene, nanos, a key regulator of germline fate, in the somatic cells of the ovary. In the female germline, we find that L(3)mbt represses testis-specific and neuronal genes. Molecularly, we show that L(3)mbt function in the ovary is mediated through its cofactor Lint1 but independent of the dREAM complex. Together, our work uncovers a more complex role for L(3)mbt than previously understood and demonstrates that L(3)mbt secures tissue identity by preventing the simultaneous expression of original identity markers and tissue-specific misexpression signatures.All rights reserved. No reuse allowed without permission.(which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

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“…Interestingly, dREAM is also involved in oogenesis in D. melanogaster , since the absence of Mip120 causes an arrest of oogenesis associated with chromosome defects. [ 86 ] However, data on the role of dREAM in oogenesis are sparse. Whether this role depends on a regulation of cell cycle or not remains to be explored.…”

Section: An Essential Complex For Various Biological Processesmentioning

confidence: 99%

DREAM a little dREAM of DRM: Model organisms and conservation of DREAM‐like complexes

Hoareau,

Rincheval‐Arnold,

Gaumer

et al. 2023

BioEssays

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DREAM complexes are transcriptional regulators that control the expression of hundreds to thousands of target genes involved in the cell cycle, quiescence, differentiation, and apoptosis. These complexes contain many subunits that can vary according to the considered target genes. Depending on their composition and the nature of the partners they recruit, DREAM complexes control gene expression through diverse mechanisms, including chromatin remodeling, transcription cofactor and factor recruitment at various genomic binding sites. This complexity is particularly high in mammals. Since the discovery of the first dREAM complex (drosophila Rb, E2F, and Myb) in Drosophila melanogaster, model organisms such as Caenorhabditis elegans, and plants allowed a deeper understanding of the processes regulated by DREAM‐like complexes. Here, we review the conservation of these complexes. We discuss the contribution of model organisms to the study of DREAM‐mediated transcriptional regulatory mechanisms and their relevance in characterizing novel activities of DREAM complexes.

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TheDrosophilaLIN54 homolog Mip120 controls two aspects of oogenesis

Cited by 5 publications

References 84 publications

L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary

L(3)mbt and the LINT complex safeguard cellular identity in the Drosophila ovary

L(3)mbt and the LINT complex safeguard tissue identity in the Drosophila ovary

DREAM a little dREAM of DRM: Model organisms and conservation of DREAM‐like complexes

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