The <i>Drosophila</i> neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells

Yarnitzky, Talia; Li, Min; Volk, Talila

doi:10.1101/gad.11.20.2691

Cited by 106 publications

(89 citation statements)

References 32 publications

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“…The timing of the observed fusion events is comparable to that reported previously for the de novo forming DFMs (Ghazi et al, 2000). The next myogenic steps, including myotube growth, recognition of cognate sr-expressing epithelial attachment sites and induction of expression of myofibrillar proteins, are similar to the previously described events that lead to the formation of the flight and body wall muscles (Becker et al, 1997;Frommer et al, 1996;Vorbruggen and Jackle, 1997;Yarnitzky et al, 1997). The most important, unique, feature of leg muscle fibres that makes them different from other Drosophila muscles is their association with the internal tendons.…”

Section: Appendicular Myogenesis Versus Larval and Flight Muscle Formsupporting

confidence: 63%

“…The final muscle pattern is seeded down by the establishment of contact between the growing myotubes and their tendonous epidermal insertion sites, called apodemes. Initially, this step involves the Stripe-dependent specification of apodemes (Becker et al, 1997;de la Pompa et al, 1989), followed by Epidermal Growth Factor Receptor (Egfr)-controlled dialogue between the apodemes and the myotubes (Strumpf and Volk, 1998;Vorbruggen and Jackle, 1997;Yarnitzky et al, 1997;Yarnitzky et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Coordinated development of muscles and tendons of theDrosophilaleg

Daczewska²,

et al. 2004

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Since Miller's morphological description, the Drosophila leg musculature and its formation has not been revisited. Here, using a set of GFP markers and confocal microscopy, we analyse Drosophila leg muscle development, and describe all the muscles and tendons present in the adult leg. Importantly, we provide for the first time evidence for tendons located internally within leg segments. By visualising muscle and tendon precursors,we demonstrate that leg muscle development is closely associated with the formation of internal tendons. In the third instars discs, in the vicinity of tendon progenitors, some Twist-positive myoblasts start to express the muscle founder cell marker dumbfounded (duf). Slightly later, in the early pupa, epithelial tendon precursors invaginate inside the developing leg segments, giving rise to the internal string-like tendons. The tendon-associated duf-lacZ-expressing muscle founders are distributed along the invaginating tendon precursors and then fuse with surrounding myoblasts to form syncytial myotubes. At mid-pupation, these myotubes grow towards their epithelial insertion sites, apodemes, and form links between internally located tendons and the leg epithelium. This leads to a stereotyped pattern of multifibre muscles that ensures movement of the adult leg.

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Section: Appendicular Myogenesis Versus Larval and Flight Muscle Formsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Coordinated development of muscles and tendons of theDrosophilaleg

Daczewska²,

et al. 2004

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“…The accumulation of STV in epidermal muscle attachment cells is most similar to the accumulation of b1Tubulin and Delilah, which are first observed in weak intersegmental stripes during stage 13, which increase in intensity during stages 15 and 16 (Armand et al 1994;Buttgereit 1996;Yarnitzky et al 1997). In contrast, kak, alien, and stripe begin to be expressed earlier, at stage 11, and always at their final intensity (Lee et al 1995;Frommer et al 1996;Goubeaud et al 1996;Strumpf and Volk 1998).…”

Section: Discussionmentioning

confidence: 60%

Drosophila starvin Encodes a Tissue-Specific BAG-Domain Protein Required for Larval Food Uptake

2005

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We describe a developmental, genetic, and molecular analysis of the sole Drosophila member of the BAG family of genes, which is implicated in stress response and survival in mammalian cells. We show that the gene, termed starvin (stv), is expressed in a highly tissue-specific manner, accumulating primarily in tendon cells following germ-band retraction and later in somatic muscles and the esophagus during embryonic stage 15. We show that stv expression falls within known tendon and muscle cell transcriptional regulatory cascades, being downstream of stripe, but not of another tendon transcriptional regulator, delilah, and downstream of the muscle regulator, mef-2. We generated a series of stv alleles and, surprisingly, given the muscle and tendon-specific embryonic expression of stv, found that the gross morphology and function of somatic muscles is normal in stv mutants. Nonetheless, stv mutant larvae exhibit a striking and fully penetrant mutant phenotype of failure to grow after hatching and a severely impaired ability to take up food. Our study provides the first report of an essential, developmentally regulated BAG-family gene.

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“…1). vein encodes a secreted EGF signaling molecule (18,19), whereas rho encodes a membrane protease that releases the Spitz EGF ligand from ventral regions of the neurogenic ectoderm (20,21). These EGF signals activate MAP kinase in both ventral and lateral regions of the neurogenic ectoderm (22).…”

Section: Cell-cell Interactions Produce Additional Dorsal Gradient Rementioning

confidence: 99%

How the Dorsal gradient works: Insights from postgenome technologies

Hong

Hendrix

Papatsenko

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

123

128

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Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60 -70 Dorsal target genes, along with the characterization of Ϸ35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.Drosophila ͉ regulatory code ͉ embryo ͉ morphogen T he dorsal-ventral (DV) patterning of the early Drosophila embryo is controlled by a sequence-specific transcription factor, Dorsal, which is related to mammalian NF-B (1-3). Differential activation of the Toll receptor leads to the formation of a broad Dorsal nuclear gradient, with peak levels present in ventral regions and progressively lower levels in lateral and dorsal regions (Fig.

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The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells

Cited by 106 publications

References 32 publications

Coordinated development of muscles and tendons of theDrosophilaleg

Coordinated development of muscles and tendons of theDrosophilaleg

Drosophila starvin Encodes a Tissue-Specific BAG-Domain Protein Required for Larval Food Uptake

How the Dorsal gradient works: Insights from postgenome technologies

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