The
            <i>DST</i>
            gene in neurobiology

Lalonde, Robert; Strazielle, Catherine

doi:10.1080/01677063.2024.2319880

Journal of Neurogenetics

2023

DOI: 10.1080/01677063.2024.2319880

|View full text |Cite

The DST gene in neurobiology

Robert Lalonde,

Catherine Strazielle

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Identification of biomarkers in Parkinson’s disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells

Zhang,

Li,

Niu

et al. 2024

Front. Aging Neurosci.

View full text Add to dashboard Cite

BackgroundParkinson’s disease (PD) is an age-related neurodegenerative disease characterized by the death of dopamine neurons in the substantia nigra. A large number of studies have focused on dopamine neurons themselves, but so far, the pathogenesis of PD has not been fully elucidated.ResultsHere, we explored the significance of oligodendrocyte precursor cells (OPCs)/oligodendrocytes in the pathogenesis of PD using a bioinformatic approach. WGCNA analysis suggested that abnormal development of oligodendrocytes may play a key role in early PD. To verify the transcriptional dynamics of OPCs/oligodendrocytes, we performed differential analysis, cell trajectory construction, cell communication analysis and hdWGCNA analysis using single-cell data from PD patients. Interestingly, the results indicated that there was overlap between hub genes and differentially expressed genes (DEGs) in OPCs not in oligodendrocytes, suggesting that OPCs may be more sensitive to PD drivers. Then, we used ROC binary analysis model to identify five potential biomarkers, including AGPAT4, DNM3, PPP1R12B, PPP2R2B, and LINC00486.ConclusionIn conclusion, our work highlights the potential role of OPCs in driving PD.

show abstract

Identification of biomarkers in Parkinson’s disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells

Zhang,

Li,

Niu

et al. 2024

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The DST gene in neurobiology

Cited by 1 publication

References 97 publications

Identification of biomarkers in Parkinson’s disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells

Identification of biomarkers in Parkinson’s disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells

Contact Info

Product

Resources

About