The <i>Ferula Assa-foetida</i> Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models

Azani, Hanieh; Tabrizi, Masoud Homayouni; Neamati, Ali; Khadem, Farzanehsadat; Khatamian, Niloufar

doi:10.1080/01635581.2021.1985533

Cited by 13 publications

(5 citation statements)

References 40 publications

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“…It shows that psychological intervention-assisted comfort care can effectively improve the patient's stress response. Analyze the reason: hypercapnia caused by breast cancer surgery, leading to increased body stress response, increased secretion of catecholamines and increased activity of the renin-angiotensin-aldosterone system, causing stress-related indicators such as HR, MAP, NE, and E increase [ 18 – 20 ]. Psychological intervention-assisted comfort nursing can reduce the anxiety of patients psychologically, improve their coping ability, meet the needs of patients from psychological, physical, and social aspects, and prompt them to deal with the stress of surgical trauma in a good psychological state [ 21 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Psychological Intervention-Assisted Comfort Nursing Based on PERMA Model on Stress and Psychological Changes of Patients after Breast Cancer Surgery

Chen

Luo²,

Cai

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the emotional response, stress and psychological changes of patients with breast cancer after surgery for psychological intervention-assisted comfort nursing based on the PERMA model. Methods. A total of 100 postoperative breast cancer patients admitted to our hospital from March 2019 to June 2021 were selected as prospective research objects. According to a random number table, they were divided into a control group and an observation group with 50 cases each. Among them, the control group implemented routine nursing care, and the observation group implemented psychological intervention-assisted comfort care based on the PERMA model on the basis of the control group. The differences in compliance behavior, self-care ability, emotional response, stress response changes, and pain scores of the two groups of breast cancer patients before and after nursing were compared. Results. After nursing, the mental behavior scores, exercise scores, medication scores, and balanced diet scores of the two groups of breast cancer patients after surgery were significantly improved. The observation group’s compliance behavior scores were significantly higher than those of the control group. In the two groups of breast cancer patients, postoperative anxiety, depression, fatigue, and anger of the patients were significantly improved, and the emotional response score of the observation group was significantly lower than that of the control group. The self-care skill score, self-responsibility score, health knowledge score, and self-concept score of the observation group were excellent compared with those of the control group; the difference was significant by the above statistics ( P < 0.05 ). The HR and MAP of the control group during the operation were higher than those 1 day before the start of the operation and decreased at the end of the operation, but still higher than the level 1 day before the start of the operation; the change trend of the observation group was the same as that of the control group, but there were differences between the time points. There was no significant significance ( P > 0.05 ). The HR and MAP of the observation group during the operation were lower than those of the control group, and the MAP at the end of the operation was lower than that of the control group. This difference was statistically significant ( P < 0.05 ). In the control group, the values increased at the time point during the operation and decreased at the end of the operation, but still higher than the level 1 day before the operation. The difference was statistically significant ( P < 0.05 ). The change trend of the observation group was the same as that of the control group; and the values during and at the end of the operation were all lower than those of the control group. This difference was statistically significant ( P < 0.05 ). The pain scores of the two groups of patients at different time points were significantly improved, and the observation group was significantly less than the control group. This difference was statistically significant ( P < 0.05 ). Conclusion. Psychological intervention-assisted comfort nursing can effectively enhance the compliance behavior of patients after breast cancer surgery, improve the emotional response, stress response, and pain of patients, and have certain reference value for the nursing of patients after breast cancer surgery.

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Section: Discussionmentioning

confidence: 99%

Effect of Psychological Intervention-Assisted Comfort Nursing Based on PERMA Model on Stress and Psychological Changes of Patients after Breast Cancer Surgery

Chen

Luo²,

Cai

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In HT-29 cells treated with OGR extract, apoptosis-related proteins including PUMA, BIM, BIK and BAK were increased, while phospho-BCL-2 was decreased. Recent studies have reported that Ferula assa-foetida L. essential oil nano-emulsion can lead to apoptosis by decreasing BCL-2 and increasing BAX expression in MCF7 breast cancer cells [21]. Also, using Ferula assa-foetida L. extract zinc nanoparticles, another study revealed apoptotic and antioxidant properties accompanied by the upregulation of Bax and downregulation of BCL-2 in HT-29, MDA-MB231, and MCF7 cell lines [39].…”

Section: Discussionmentioning

confidence: 94%

“…Assa-foetida OGR is traditionally used as an analgesic, sexual aphrodisiac, anticonvulsant, and anthelmintic agent [17]. In various tumors, the cytotoxic and anticancer effects of Ferula assa-foetida L. have been studied [17,21].…”

Section: Introductionmentioning

confidence: 99%

Antitumor and Phytochemical Properties of Ferula assa-foetida L. Oleo-Gum–Resin against HT-29 Colorectal Cancer Cells In Vitro and in a Xenograft Mouse Model

Elarabany,

Hamad,

Alzamel

2023

Molecules

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Colorectal cancer (CRC) is one of the most frequently occurring tumors. Ferula assa-foetida oleo-gum–resin (OGR) extract is a traditional cooking spice known for its broad spectrum of biological activities such as antifungal, antiparasitic, and anti-inflammatory activities. This study evaluated the antitumor effect of OGR extract against HT-29 colorectal cancer cells. The OGR chemical composition was analyzed using LC–ESI–MS/MS; MTT, clonogenic assays, and a xenograft model were used to measure cytotoxicity, while apoptotic proteins were detected using Western blotting. Phytochemical analysis revealed that the extract was a rich source of isoflavones, xanthones, and other derivatives. In a dose-dependent manner, the OGR extract significantly inhibited colony formation ability and HT-29 cell growth (IC50 was 3.60 ± 0.02 and 10.5 ± 0.1 mg/mL, respectively). On the other hand, the OGR extract significantly induced apoptosis and increased the expression of some pro-death proteins involved in cellular apoptosis including PUMA, BIM, BIK, and BAK. Moreover, in a subcutaneous HT-29 xenograft model, the tumor volume and burden decreased after treatment with the OGR extract (550 ± 32 mm3 and 16.3 ± 3.6, respectively) This study demonstrated that Ferula assa-foetida OGR ethanolic extract has potential antitumor effects against HT-29 CRC cell lines by reducing cell viability and the function of apoptosis. More studies are needed to reveal the underlying mechanisms related to cytotoxicity and apoptosis induction.

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“…Fifty microliters of CSONE or CSO in methanol over the range of 15.6-250 μg/mL were added to 5 mL of a 0.04% methanol solution of DPPH. These concentrations were selected based on previous studies on NE formulation [29,30]. After a 30 min incubation at room temperature, the absorbance was read against a blank at 517 nm with an ELISA microplate reader (xMark ™ , BIO-RAD, Australia).…”

Section: The Antioxidant Activity Of Csonementioning

confidence: 99%

Optimisation of Calophyllum inophyllum seed oil nanoemulsion as a potential wound healing agent

Saki

Murthy

Khandanlou

et al. 2022

BMC Complement Med Ther

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Background Efficient delivery systems of Calophyllum inophyllum seed oil (CSO) in the form of nanoemulsion were optimised to enhance its stability and ensure its therapeutic efficiency as a potential agent for various biomedical applications. Method Response Surface Methodology (RSM) was used to determine the effects of independent variables (oil, surfactant, water percentage and homogenisation time) on physicochemical characteristics, including droplet size, polydispersity index and turbidity. Results The optimised CSO nanoemulsion (CSONE) has a 46.68 nm particle size, 0.15 Polydispersity index value and 1.16 turbidity. After 4 weeks of storage at 5 ± 1 °C and 25 ± 1 °C, the CSONE was physically stable. The optimised CSO nanoemulsion showed enhancement in cell viability and wound healing in baby hamster kidney a clone BHK-21 (BSR) cells as compared to the CSO. The wound healing property of CSONE was higher than CSO. Conclusion Thus, our in vitro wound healing results demonstrated that CSO in the nanoemulsion form can promote wound healing by enhancing the proliferation and migration of epidermal cells. Graphical Abstract The coarse emulsion of Calophyllum inophyllum seed oil nano emulsion was prepared using high shear homogeniser techniques. The optimised CSONE with the droplet size of 46.68 nm was prepared from a mixture of CSO, Tween 80, and high pure water (HPW), then used for the biological investigation. The in vitro cell monolayer scratch assay revealed that CSONE in the lowest concentration of CSO resulted in 100% wound closure after 48 hrs. The optimised CSO nanoemulsion was found to be a promising and effective approach in the treatment of wounds by boosting the proliferation and migration of epidermal cells.

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The Ferula Assa-foetida Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models

Cited by 13 publications

References 40 publications

Effect of Psychological Intervention-Assisted Comfort Nursing Based on PERMA Model on Stress and Psychological Changes of Patients after Breast Cancer Surgery

Effect of Psychological Intervention-Assisted Comfort Nursing Based on PERMA Model on Stress and Psychological Changes of Patients after Breast Cancer Surgery

Antitumor and Phytochemical Properties of Ferula assa-foetida L. Oleo-Gum–Resin against HT-29 Colorectal Cancer Cells In Vitro and in a Xenograft Mouse Model

Optimisation of Calophyllum inophyllum seed oil nanoemulsion as a potential wound healing agent

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