The
            <i>glmS</i>
            Ribozyme and Its Multifunctional Coenzyme Glucosamine‐6‐phosphate

Soukup, Juliane K.

doi:10.1002/9783527814527.ch4

Cited by 1 publication

(1 citation statement)

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“…The glucosamine-6-phosphate synthase (glmS) ribozyme is found in several Gram-positive bacteria in the 5' UTR region of the glmS gene [32]. It regulates the expression of glutamine-fructose-6-phosphate transaminase and is the only known ribozyme which requires glucosamine-6-phosphate (GlcN6P) as a co-factor [33]. The glmS ribozyme comprises three parallel helices stacking each other (P1 on P3.1, P4 on P4.1 and P2.1).…”

Section: Mechanism Of Catalysis In Ribozymes: Ribozymes Perform Rever...mentioning

confidence: 99%

Ribozymes as Therapeutic Agents against Infectious Diseases

Wong¹,

Shahid²,

Tan³

2023

RNA Therapeutics - History, Design, Manufacturing, and Applications

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Ribozymes, also known as RNA enzymes, are catalytic RNA molecules capable of cleaving specific RNA sequences, leading to decreased expression of targeted genes. Recent studies suggest their role in cancer therapeutics, genetic diseases and retroviral infections. This book chapter will focus on ribozymes acting as therapeutic agents against infectious diseases caused by viral and bacterial pathogens. Firstly, we will introduce a brief history of ribozymes and a general overview of ribozymes and their characteristics. Next, different types of ribozymes will be explored regarding their targets and mechanisms of action. After that, ribozymes specific to viral and bacterial infections will be explored. We will briefly discuss the current status of ribozymes as therapeutic agents. Finally, the roadblock and challenges ribozymes face before being developed into therapeutic agents—such as their delivery and efficacy issues—will be discussed.

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Section: Mechanism Of Catalysis In Ribozymes: Ribozymes Perform Rever...mentioning

confidence: 99%