TheIn VivoDiagnosis of Malaria: Feasibility Study Into a Magneto-Optic Fingertip Probe

Theoretical models for near forward light scattering by aPlasmodium falciparuminfected red blood cell

“…It is, therefore, desirable to develop faster, noninvasive and innovative automated methods which are independent of operator bias and skill. With these requirements in mind, there is considerable interest currently in examining the potential of the elastic light scattering technique as an alternative to conventional methods for quick and reliable diagnosis of malaria [2][3][4][5][6][7][8][9][10][11][12].…”

“…Hemoglobin content and sizes of infected erythrocytes have been studied by Hanssen et al [7] using soft X-rays. The scattering characteristics of malaria byproduct hemozoin, including its scattering distribution and depolarization, have also been examined [9,10]. Brief reviews [ 11,12] on the biophotonic techniques for the study of malaria-infected red blood cells have been published recently.…”

In vivo microscopy of hemozoin: towards a needle free diagnostic for malaria

“…This approach is made feasible by exploiting the endogenous optical properties of hemozoin. The needle-free detection of hemozoin has previously been demonstrated in vivo using magneto-optical and opto-acoustical techniques [8,9], however these approaches use expensive components with significant power requirements making them difficult to implement in low resource settings where malaria is endemic. The design of the MVM was chosen to avoid the need for elaborate alignment or use of costly optical elements and detectors.…”

“…Owing to its crystalline nature, hemozoin is a highly scattering, birefringent material with strong optical absorbance and paramagnetic properties, making it an ideal candidate for in vivo optical interrogation [5,6]. Hemozoin has been explored as an endogenous malaria optical biomarker using laser desorption mass spectrometry, magnetooptic detection, and vapor nanobubble acoustical detection [7][8][9]. In this work, we explore the use of in vivo microscopy to detect hemozoin circulating in the microvasculature.…”

Controlling Nanoparticles Formation in Molten Metallic Bilayers by Pulsed-Laser Interference Heating

“…The applications of such materials can be widespread. For instance, plasmonic -ferromagnetic materials can be used to improve chemical sensing time scales [35][36][37], quantify disease detection [38][39][40], and improve high-speed optical communication circuits [41,42]. However, existing synthesis routes utilizing thin film or liquid routes have found it difficult to independently control the nanoparticle size and composition over a wide range [43][44][45].…”