The in vivo effects of cefazolin, cefuroxime, and cefoperazon on the carbonic anhydrase in different rat tissues

Abstract

In this paper, the in vivo effects of some antibiotics including cefazolin, cefuroxime, and cefoperazon, on the activity of the carbonic anhydrase enzyme (CA) in heart, brain, eye, liver, and kidney tissues of rats were evaluated. For this purpose, 16 different groups, which each containing six rats (n = 6), were formed (control group, cefazolin groups, cefuroxime groups, and cefoperazon groups). The rats were necropsied 60 min after the intraperitoneal injection of the chemicals into the rats. The CA activities were measured for each tissue using esterase activity methods. The activity values for each tissue obtained were statistically calculated. The CA activities in the liver tissue were assessed, and the activities of the cefoperazon groups were decreased compared to the sham groups from the third hour (p < 0.05). In the cefuroxime and cefoperazon groups, the CA activities in the eye tissue were decreased during the first 3 h and then increased (p < 0.05).

Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease

“…The reaction was also started by adding 50 μL BChI/AChI. The activity of these enzymes was evaluated using spectrophotometric spectra with a wavelength of 412 nm …”

Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors

“…This enzyme has great importance for hydrolysis choline esters in the cholinergic synapses of the nervous system, central nervous system, and somatic system. BChE, which is a nonspecific ChE, is found in the blood plasma and serum, pancreas, heart, central nervous system, and liver of vertebrates . BChE hydrolyzes choline esters and different esters.…”

Inhibition profiles of Voriconazole against acetylcholinesterase, α‐glycosidase, and human carbonic anhydrase I and II isoenzymes

“…Voriconazole is an antifungal medication used to treat a number of fungal infections, and its inhibitory effects against some metabolic enzymes are shown in Table and Figures . Previous research has clearly indicated that the inhibitory effect of Voriconazole against hCA I, hCA II, AChE, and α‐glycosidase is greater than or equal to that of morphine, antioxidant phenols, hydroquinone, taxifolin, spirobisnaphthalenes, caffeic acid phenethyl ester, rosmarinic acid, some hydroperoxides, alcohols and acetates, some ureas, eugenol derivatives, lignans, thioureas, flavonoids, synephrine and phenylephrine, avermectins, antibiotics, and TAC derivatives . The present study adds to this previous literature (Table ).…”