The Klotho Variant rs36217263 Is Associated With Poor Response to Cardioselective Beta‐Blocker Therapy Among Filipinos

Sy, Rody G.; Nevado, Jose B.; Llanes, Elmer Jasper B.; Magno, Jose Donato A.; Ona, Deborah Ignacia D.; Punzalan, Felix Eduardo R.; Reganit, Paul Ferdinand M.; Santos, Lourdes Ella G.; Tiongco, Richard Henry P.; Aherrera, Jaime Alfonso M.; Abrahan, Lauro L.; Agustin, Charlene F.; Aman, Aimee Yvonne Criselle; Bejarin, Adrian John P.; Paz, Eva Maria C. Cutiongco de la

doi:10.1002/cpt.1585

Cited by 7 publications

(10 citation statements)

References 13 publications

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“…In addition to African Americans and European-Americans, recent studies have used GWAS approach to identify genetic polymorphisms associated with blood pressure responses to atenolol in other populations. This is the case of a study performed by Sy et al, which investigated the association of genetic variants with antihypertensive responses to β-blockers among Filipinos 67. Interestingly, they found that the deletion of at least one copy of allele A for rs36217263 polymorphism in the Klotho gene is associated with poor response to β-blockers.…”

Section: β-Blockersmentioning

confidence: 98%

Pharmacogenomics And Hypertension: Current Insights

Oliveira-Paula

Pereira

Tanus‐Santos

et al. 2019

PGPM

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Hypertension is a multifactorial disease that affects approximately one billion subjects worldwide and is a major risk factor associated with cardiovascular events, including coronary heart disease and cerebrovascular accidents. Therefore, adequate blood pressure control is important to prevent these events, reducing premature mortality and disability. However, only one third of patients have the effective control of blood pressure, despite several classes of antihypertensive drugs available. These disappointing outcomes may be at least in part explained by interpatient variability in drug response due to genetic polymorphisms. To address the effects of genetic polymorphisms on blood pressure responses to the antihypertensive drug classes, studies have applied candidate genes and genome wide approaches. More recently, a third approach that considers gene-gene interactions has also been applied in hypertension pharmacogenomics. In this article, we carried out a comprehensive review of recent findings on the pharmacogenomics of antihypertensive drugs, including diuretics, β-blockers, angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, and calcium channel blockers. We also discuss the limitations and inconsistences that have been found in hypertension pharmacogenomics and the challenges to implement this valuable approach in clinical practice.

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Section: β-Blockersmentioning

confidence: 98%

Pharmacogenomics And Hypertension: Current Insights

Oliveira-Paula

Pereira

Tanus‐Santos

et al. 2019

PGPM

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“…Quality control and statistical analyses were similar to the methods in studies published earlier by the authors. 22,23…”

Section: Discussionmentioning

confidence: 99%

“…They were also excluded if they were related to other enrolled participants up to 3 rd degree of consanguinity. 22,23…”

Section: Study Design and Enrollment Of Participantsmentioning

confidence: 99%

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Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos

et al. 2021

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Objective. Several studies showed that genetic factors affect responsiveness to statins among different populations. This study investigated the associations of candidate genetic variants with poor response to statins among Filipinos.Methods. In this unmatched case-control study, dyslipidemic participants were grouped into statin responders and poor responders based on the degree of reduction in LDL-c from baseline. DNA from blood samples were genotyped and analyzed. The association of candidate variants with statin response was determined using chi-square and logistic regression analysis.Results. We included 162 adults on statins (30 poor responders as cases, 132 good responders as controls). The following variants are nominally associated with poor response to statin among Filipinos at a per-comparison error rate of 0.05: rs173539 near CETP (OR=3.05, p=0.015), rs1800591 in MTTP (OR=3.07, p=0.021), and rs1558861 near the BUD13-ZPR1-APOA5 region (OR=5.08, p=0.004). Conclusion.Genetic variants near CETP, MTTP and the BUD13-ZPR1-APOA5 region are associated with poor response to statins among Filipinos. Further study is recommended to test the external validity of the study in the general Filipino population.

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“…Quality control and statistical analyses were similar to the methods done in studies published earlier. [14][15]…”

Section: Logistic Regression Analysismentioning

confidence: 99%

A Genetic Polymorphism in GCKR may be Associated with Low High-Density Lipoprotein Cholesterol Phenotype among Filipinos: A Case-Control Study

Nevado

Gonzales

et al. 2021

Acta Med Philipp

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Background. Low levels of high-density lipoprotein cholesterol (HDL-c) is a well-recognized risk factor in the development of cardiovascular diseases. Associated gene variants for low HDL-c have already been demonstrated in various populations. Such associations have yet to be established among Filipinos who reportedly have a much higher prevalence of low HDL-c levels compared to other races.Objective. To determine the association of selected genetic variants and clinical factors with low HDL-c phenotype in Filipinos.Methods. An age-and sex-matched case-control study was conducted among adult Filipino participants with serum HDL-c concentration less than 35 mg/dL (n=61) and those with HDL-c levels of more than 40 mg/dL (n=116). Genotyping was done using DNA obtained from blood samples. Candidate variants were correlated with the low HDL-c phenotype using chi-squared test and conditional logistic regression analysis.Results. Twelve single nucleotide polymorphisms (SNPs) were associated with low HDL-c phenotype among Filipinos with univariate regression analysis. The variant rs1260326 of glucokinase regulator (GCKR) (CT genotype: adjusted OR=5.17; p-value=0.007; TT genotype: adjusted OR=6.28; p-value=0.027) remained associated with low HDL-c phenotype, together with hypertension and elevated body mass index, after multiple regression analysis. Conclusion.The variant rs1260326 near GCKR is associated with low HDL-c phenotype among Filipinos. Its role in the expression of low HDL-c phenotype should be further investigated prior to the development of possible clinical applications.

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The Klotho Variant rs36217263 Is Associated With Poor Response to Cardioselective Beta‐Blocker Therapy Among Filipinos

Cited by 7 publications

References 13 publications

<p>Pharmacogenomics And Hypertension: Current Insights</p>

<p>Pharmacogenomics And Hypertension: Current Insights</p>

Variants Near CETP, MTTP and BUD13-ZPR1-APOA5 may be Nominally Associated with Poor Statin Response Among Filipinos

A Genetic Polymorphism in GCKR may be Associated with Low High-Density Lipoprotein Cholesterol Phenotype among Filipinos: A Case-Control Study

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