The<i>microRNA-23b/27b/24-1</i>cluster is a disease progression marker and tumor suppressor in prostate cancer

Goto, Yusuke; Kojima, Satoko; Nishikawa, Rika; Enokida, Hideki; Chiyomaru, Takeshi; Kinoshita, Takashi; Nakagawa, Masayuki; Naya, Yukio; Ichikawa, Tomohiko; Seki, Naohiko

doi:10.18632/oncotarget.2294

Cited by 119 publications

(151 citation statements)

References 39 publications

Supporting

Mentioning

137

Contrasting

Unclassified

Order By: Relevance

“…20 [39], breast cancer [40], cervical cancer [41], nasopharyngeal carcinoma [42], lung carcinoma [43], and gastric cancer [37]. In contrast with a previous study [24], we hereby show that miR-24-3p levels do not significantly differ between colorectal adenocarcinoma and non-cancerous colorectal mucosae.…”

Section: Accepted Manuscriptcontrasting

confidence: 93%

Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma

Kerimis

Kontos

Christodoulou

et al. 2017

Clinical Biochemistry

View full text Add to dashboard Cite

Section: Accepted Manuscriptcontrasting

confidence: 93%

Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma

Kerimis

Kontos

Christodoulou

et al. 2017

Clinical Biochemistry

View full text Add to dashboard Cite

“…In this study, ZNF238 was targeted by over-expressed miR-20b, which was reported to be an oncogenic miRNA (Li et al, 2013). Conversely, ZNF267 was a target gene of the antineoplastic miRNAs -23a and -23b (Goto et al, 2014;Xishan et al, 2014), both of which were downregulated in our study. Given that the role of miRNAs generally lies in negatively regulating target gene expression, miR-20b might be positively correlated with leukemogenesis by directly inhibiting the expression of the tumor suppressive ZNF238 protein.…”

Section: Discussionsupporting

confidence: 45%

Regulation of the expression of zinc finger protein genes by microRNAs enriched within acute lymphoblastic leukemia-derived microvesicles

Lü¹,

Chen²,

Tao³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Microvesicles (MVs) are submicrometric membrane fragments that can "engulf" cytoplasmic contents such as microRNAs (miRNAs) from their cellular origin. The study of miRNAs carried within MVs might provide insights into the roles that miRNAs play in the underlying pathophysiologic processes of acute lymphoblastic leukemia (ALL). We identified numerous dysregulated MV miRNAs in patients with B-and T-cell ALL by using Agilent microarray analysis. Selected miRNAs obtained by microarray profiling were validated using quantitative reverse transcription-polymerase chain reaction. Using bioinformatic tools, we found that 118 and 116 miRNAs from Band T-ALL MVs, respectively, regulated the expression of zinc finger protein (ZFP) genes. For example, zinc finger protein 238 (ZNF238), known as a tumor suppressor, was regulated by miR-20b over-expression. Conversely, ZNF267, a cancer-promoting factor, was mediated by downregulated miR-23a and miR-23b. Considering that miRNAs are generally believed to repress gene expression, antineoplastic ZNF238 was likely inhibited while the level of oncogenic ZNF267 was likely increased by miRNA dysregulation, leading to modification of the ALL microenvironment. In addition, gene ontology and signaling pathway analysis demonstrated that a subset of the ZFP genes targeted by altered MV miRNAs are involved in cellular biological processes including proliferation, differentiation, apoptosis, and cell cycle regulation. These findings indicated that cancer-associated MV miRNAs and their target ZFP genes might be novel pathogenic factors in ALL. However, the specific roles exerted by MV miRNAs and their target ZFP genes on the pathological mechanisms of ALL remain to be further understood.

show abstract

“…Several studies have reported that numerous miRNAs may be independent biochemical recurrence prediction markers (35)(36)(37)(38). The present study aimed to investigate the potential of miR-17-92 cluster derived from surgery at the initial visit in predicting the possibility of PCa progression or metastasis, and the results obtained demonstrated that the expression status of the miR-17-92 cluster was a good prognostic marker for time to progression to biochemical recurrence.…”

Section: Discussionmentioning

confidence: 80%

Combinations of elevated tissue miRNA‑17‑92 cluster expression and serum prostate‑specific antigen as potential diagnostic biomarkers for prostate cancer

Feng

Qian

et al. 2017

Oncol Lett

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the effectiveness of the miR-17-92 cluster as a disease progression marker in prostate cancer (PCa). Reverse transcription-quantitative polymerase chain reaction analysis was used to detect the microRNA (miR)-17-92 cluster expression levels in tissues from patients with PCa or benign prostatic hyperplasia (BPH), in addition to in PCa and BPH cell lines. Spearman correlation was used for comparison and estimation of correlations between miRNA expression levels and clinicopathological characteristics such as the Gleason score and prostate-specific antigen (PSA). Receiver operating curve (ROC) analysis was performed for evaluation of specificity and sensitivity of miR-17-92 cluster expression levels for discriminating patients with PCa from patients with BPH. Kaplan-Meier analysis was plotted to investigate the predictive potential of miR-17-92 cluster for PCa biochemical recurrence. Expression of the majority of miRNAs in the miR-17-92 cluster was identified to be significantly increased in PCa tissues and cell lines. Bivariate correlation analysis indicated that the high expression of unregulated miRNAs was positively correlated with Gleason grade, but had no significant association with PSA. ROC curves demonstrated that high expression of miR-17-92 cluster predicted a higher diagnostic accuracy compared with PSA. Improved discriminating quotients were observed when combinations of unregulated miRNAs with PSA were used. Survival analysis confirmed a high combined miRNA score of miR-17-92 cluster was associated with shorter biochemical recurrence interval. miR-17-92 cluster could be a potential diagnostic and prognostic biomarker for PCa, and the combination of the miR-17-92 cluster and serum PSA may enhance the accuracy for diagnosis of PCa.

show abstract

ThemicroRNA-23b/27b/24-1cluster is a disease progression marker and tumor suppressor in prostate cancer

Cited by 119 publications

References 39 publications

Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma

Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma

Regulation of the expression of zinc finger protein genes by microRNAs enriched within acute lymphoblastic leukemia-derived microvesicles

Combinations of elevated tissue miRNA‑17‑92 cluster expression and serum prostate‑specific antigen as potential diagnostic biomarkers for prostate cancer

Contact Info

Product

Resources

About