The<i>PSE1</i>gene modulates lead tolerance in Arabidopsis

Fan, Tingting; Yang, Libo; Wu, Xi; Ni, Junjie; Jiang, Haikun; Zhang, Qian; Fang, Ling; Sheng, Yibao; Ren, Yongbing; Cao, Shuqing

doi:10.1093/jxb/erw251

Cited by 36 publications

(24 citation statements)

References 60 publications

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“…Hattab et al [258] observed a significant increase in ROS and cellular oxidative stress in Medicago sativa through influencing the expression of CuZn-SOD, GSH synthase (GS), and GPX against Pb stress. Fan et al [259] observed an unknown protein, product of PSE1 (Pb-sensitive1) gene with NC domain, which is localized in cytoplasm and has potential for Pb tolerance in A. thaliana. Jiang et al [260] studied the role of PDR12 knockout Arabidopsis and under Pb stress conditions and concluded that PDR12 is responsible for the activation of a Pb exclusion mechanism.…”

Section: Biotechnological and Genetic Approachesmentioning

confidence: 99%

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Kumar

Pinto

Chaturvedi

et al. 2020

IJERPH

627

229

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Lead (Pb) toxicity has been a subject of interest for environmental scientists due to its toxic effect on plants, animals, and humans. An increase in several Pb related industrial activities and use of Pb containing products such as agrochemicals, oil and paint, mining, etc. can lead to Pb contamination in the environment and thereby, can enter the food chain. Being one of the most toxic heavy metals, Pb ingestion via the food chain has proven to be a potential health hazard for plants and humans. The current review aims to summarize the research updates on Pb toxicity and its effects on plants, soil, and human health. Relevant literature from the past 20 years encompassing comprehensive details on Pb toxicity has been considered with key issues such as i) Pb bioavailability in soil, ii) Pb biomagnification, and iii) Pb- remediation, which has been addressed in detail through physical, chemical, and biological lenses. In the review, among different Pb-remediation approaches, we have highlighted certain advanced approaches such as microbial assisted phytoremediation which could possibly minimize the Pb load from the resources in a sustainable manner and would be a viable option to ensure a safe food production system.

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Section: Biotechnological and Genetic Approachesmentioning

confidence: 99%

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Kumar

Pinto

Chaturvedi

et al. 2020

IJERPH

627

229

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“…Anthropogenic activities have been considered as the worst culprit of HMs toxicity. Increasing urbanization and industrialization add HMs to the environment and cause disruption of pristine ecosystems (Ross, 1994;Fan et al, 2016). Furthermore, agriculture intensification through excessive use of fertilizers and insecticides, and wastewater discharge also add HMs to the environment (Shen et al, 2002;Sharma and Dubey 2005;Khan et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Of these, Pb is a toxic HM that adversely affects plant growth and metabolism (Sharma and Dubey 2005;Dogan et al, 2009). Lead enters the plants via their roots and alters their morphological, physio-biochemical and molecular mechanisms (Fan et al, 2016;Mahdavian et al, 2016;Malar et al, 2016;Simonetti et al, 2016). Lead limits seed germination, biomass production and also causes nutrients imbalance in plants (Sharma and Dubey 2005;Malar et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Ascorbic acid improves the tolerance of wheat plants to lead toxicity

Alamri

Siddiqui

Al-Khaishany

et al. 2018

Journal of Plant Interactions

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Among the heavy metals (HMs), lead (Pb) is considered as a toxic HM which adversely affects growth and development of crop plants. The present experiment was aimed to investigate the potential role of ascorbic acid (ASC) in the reversal of Pb-inhibited nitrogen and sulfur assimilation enzymes activity and activity of photosynthesis enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) and growth response in wheat plants. Wheat seedlings were subjected to 0 mM (control) and 0.2 mM and 0.6 mM of ASC with and without 2 mM of Pb. Plants treated with Pb exhibited the following reduced growth characteristics (root length, shoot length, root fresh weight (FW), shoot FW, root dry weight (DW) and shoot DW). A decrease was also observed in the activity of Rubisco and ATP sulfurylase (ATP-S), relative water content (RWC), accumulation of total chlorophyll (Total Chl) and content of nutrients [nitrogen (N), phosphorus (P), potassium (K), calcium (Ca) and magnesium (Mg)] in Pb-treated plants. However, an increase in Chl degradation and in the activity of O-acetylserine(thiol)lyase (OAS-TL) and accumulation of cysteine (Cys), malondialdehyde (MDA) and hydrogen peroxide (H 2 O 2 ) was observed in plants under Pb stress. On the contrary, exogenous application of ASC mitigated the Pb-toxicity-induced oxidative damage by enhancing the activities of antioxidant enzymes, such as superoxide dismutase, catalase and glutathione reductase. Improved activity of antioxidant enzymes suppressed the formation of MDA and H 2 O 2 , which was reflected in the form of improved growth characteristics. Moreover, ASC induced improvement in plants defense systems by reduced Chl degradation and improved the content of essential nutrients (N, P, K, Ca and Mg) and Cys, RWC and the activity of Rubisco, ATP-S, NR and OAS-TL. ARTICLE HISTORY

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“…Flavonoids act as ROS scavengers and metal chelators, and isoflavonoids act as phytoalexins in response to heavy metals [4]. Glutathione plays an important role in heavy metal detoxification [19, 50] and is not only an important antioxidant but also participates in metal transport processes [4, 45, 55]. In this study, both transcriptome data and qRT-PCR analysis indicated that DEGs that encode flavonoid synthase genes were significantly upregulated under Pb stress (Fig 5, Table 3, S5 Table).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic and physiological analyses of Medicago sativa L. roots in response to lead stress

Wang

Zhang

et al. 2017

PLoS ONE

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Lead (Pb) is one of the nonessential and toxic metals that threaten the environment and human health. Medicago sativa L. is a legume with high salt tolerance and high biomass production. It is not only a globally important forage crop but is also an ideal plant for phytoremediation. However, the biological and molecular mechanisms that respond to heavy metals are still not well defined in M. sativa. In this study, de novo and strand-specific RNA-sequencing was performed to identify genes involved in the Pb stress response in M. sativa roots. A total of 415,350 unigenes were obtained from the assembled cDNA libraries, among which 5,416 were identified as significantly differentially expressed genes (DEGs) (false discovery rate < 0.005) between cDNA libraries from control and Pb-treated plants. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the DEGs showed they mainly clustered with terms associated with binding, transport, membranes, and the pathways related to signal and energy metabolism. Moreover, a number of candidate genes included antioxidant enzymes, metal transporters, and transcription factors involved in heavy metal response were upregulated under Pb stress. Quantitative real-time PCR(qRT-PCR) validation of the expression patterns of 10 randomly selected candidate DEGs were consistent with the transcriptome analysis results. Thus, this study offers new information towards the investigation of biological changes and molecular mechanisms related to Pb stress response in plants.

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ThePSE1gene modulates lead tolerance in Arabidopsis

Abstract: Highlight PSE1 regulates Pb tolerance mainly through GSH-dependent phytochelatin synthesis by activating the expression of the genes involved in phytochelatin synthesis and at least partially through activating the expression of PDR12.

Cited by 36 publications

References 60 publications

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches

Ascorbic acid improves the tolerance of wheat plants to lead toxicity

Transcriptomic and physiological analyses of Medicago sativa L. roots in response to lead stress

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