The<i>Srb1+1050T</i>Allele Is Associated with Metabolic Syndrome in Children but Not with Cholesteryl Ester Plasma Concentrations of High-Density Lipoprotein Subclasses

Juárez-Meavepeña, Minerva; Carreón‐Torres, Elizabeth; López-Osorio, Cristhel; García-Sánchez, Cynthia; Gamboa, Ricardo; Torres-Tamayo, Margarita; Fragoso, José Manuel; Rodrı́guez-Pérez, José Manuel; Vargas‐Alarcón, Gilberto; Pérez-Méndez, Óscar

doi:10.1089/met.2011.0071

Cited by 13 publications

(11 citation statements)

References 46 publications

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“…Table 3 Cholesterol-and triglycerides-to-phospholipids plasma concentration ratios of HDL subclasses in the studied groups. subclasses is a better indicator of the absolute concentrations of these particles and is useful for estimating the composition of HDL [12,13,33]. The cholesterol-to-phospholipids ratio of HDL subclasses is an indicator of the cholesterol content of these lipoproteins [13].…”

Section: Discussionmentioning

confidence: 99%

“…No differences were observed in the CAC <25th group compared with the CAC ¼ 0 group. Given that the plasma concentrations of the phospholipids of HDL subclasses may be markers of the numbers of lipoprotein particles [12,13], it may be that subjects with high levels of calcification had lower plasma levels of HDL particles than subjects with low levels or subjects without detectable coronary calcification. This interpretation of the data is consistent with previous reports suggesting that low numbers of HDL particles, as determined by RMN, are a predictor of CAD [4], and contributes further to our knowledge in this field, as we demonstrated that low levels of HDL particles are detectable during the asymptomatic stages of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…Gels were stained for total cholesterol, non-esterified (free) cholesterol, phospholipids and triglycerides using enzymatic mixtures previously described by us [12,13,33]. Incubation times ranged between 60 and 75 min at 37 C, in the dark, for any lipid stained on electrophoresis gels [13].…”

Section: Characterization Of Hdl Subclassesmentioning

confidence: 99%

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Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

et al. 2015

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“…Plasma total cholesterol, triglyceride, and phospholipid concentrations corresponding to each HDL subclass were estimated as previously described . The mean intra‐assay variations in the relative proportions of the five HDL subclasses were 6.9 and 5.6% for cholesterol and for the phospholipids, respectively, as previously reported .…”

Section: Methodsmentioning

confidence: 98%

Atorvastatin and fenofibrate combination induces the predominance of the large HDL subclasses and increased apo AI fractional catabolic rates in New Zealand white rabbits with exogenous hypercholesterolemia

Flores-Castillo

Zamora-Pérez

Carreón‐Torres

et al. 2015

Fundamemntal Clinical Pharma

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The anti-atherogenic properties of high-density lipoproteins (HDLs) may be related to their structure and metabolism. The HDL physicochemical characteristics that determine their plasma clearance during treatment with statins and fibrates are not well understood. In this study, we analyzed HDL-apo AI fractional catabolic rates (FCRs), size distributions, and the lipid composition of the HDL subclasses in New Zealand white rabbits with exogenous dyslipidemia that received low doses of atorvastatin and fenofibrate. Hypercholesterolemia decreased only partially with the combination of both drugs. HDL size distribution shifted toward larger particles among the groups of rabbits that received atorvastatin, fenofibrate, or their combination, compared with both the control group and the dyslipidemic group. The HDL subclasses were significantly rich in cholesterol in each of the groups compared with controls. The structural changes noted in the HDL subclasses were not associated with impaired plasma paraoxonase-1 (PON1) activity. The groups receiving monotherapy and the drug combination group were all associated with a higher apo AI FCR value compared with both the dyslipidemic rabbits and the control group. In conclusion, the combination of atorvastatin and fenofibrate induced a more favorable HDL subclass profile than did the individual use of these drugs. Similarly, the apo AI FCR values were augmented in every group receiving drug treatment (either monotherapy or combination therapy) in the setting of hypercholesterolemia. The anti-atherogenic properties of HDLs, excluding their capacity to bind PON1, may be enhanced by the structural and metabolic modifications induced by the combination of atorvastatin and fenofibrate.

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“…The scavenger receptor Class-B member 1 (SRB1) is a type-II double-pass transmembrane receptor for high-density lipoproteins (HDL) in liver, placenta, adrenal and steroidogenic tissues [47]. The SRB1 receptor attaches to cholesterol and sphingomyelin domains of the bilipid cell membrane.…”

Section: The Srb1 Receptormentioning

confidence: 99%

The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets

2015

Journal of Drug Targeting

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Recent studies have demonstrated that the carboxyterminal third domain of alpha-fetoprotein (AFP-CD) binds with various ligands and receptors. Reports within the last decade have established that AFP-CD contains a large fragment of amino acids that interact with several different receptor types. Using computer software specifically designed to identify protein-to-protein interaction at amino acid sequence docking sites, the computer searches identified several types of scavenger-associated receptors and their amino acid sequence locations on the AFP-CD polypeptide chain. The scavenger receptors (SRs) identified were CD36, CD163, Stabilin, SSC5D, SRB1 and SREC; the SR-associated receptors included the mannose, low-density lipoprotein receptors, the asialoglycoprotein receptor, and the receptor for advanced glycation endproducts (RAGE). Interestingly, some SR interaction sites were localized on the AFP-derived Growth Inhibitory Peptide (GIP) segment at amino acids #480-500. Following the detection studies, a structural subdomain analysis of both the receptor and the AFP-CD revealed the presence of epidermal growth factor (EGF) repeats, extracellular matrix-like protein regions, amino acid-rich motifs and dimerization subdomains. For the first time, it was reported that EGF-like sequence repeats were identified on each of the three domains of AFP. Thereafter, the localization of receptors on specific cell types were reviewed and their functions were discussed.

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TheSrb1+1050TAllele Is Associated with Metabolic Syndrome in Children but Not with Cholesteryl Ester Plasma Concentrations of High-Density Lipoprotein Subclasses

Abstract: Srb1 +1050T was associated with metabolic syndrome, but T carrier subjects did not show important differences concerning HDL subclasses as compared to noncarriers.

Cited by 13 publications

References 46 publications

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

Atorvastatin and fenofibrate combination induces the predominance of the large HDL subclasses and increased apo AI fractional catabolic rates in New Zealand white rabbits with exogenous hypercholesterolemia

The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets

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