The <i>strawberry notch</i> gene functions with <i>Notch</i> in common developmental pathways

Coyle-Thompson, Catherine; Banerjee, Utpal

doi:10.1242/dev.119.2.377

Cited by 42 publications

(8 citation statements)

References 62 publications

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“…Apart from a slight decrease in the body weight, we observed no overt abnormalities in Sbno2 −/− mice, indicating minor roles for SBNO2 during physiological conditions. This differs from other strawberry notch family homologs, including murine SBNO1, which have important or critical roles in development [ 24 , 49 ]. However, our findings support those by Maruyama et al .…”

Section: Discussionmentioning

confidence: 99%

Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system

Syme

Grill

Hayashida

et al. 2022

J Neuroinflammation

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Background The cytokine interleukin-6 (IL-6) modulates a variety of inflammatory processes and, context depending, can mediate either pro- or anti-inflammatory effects. Excessive IL-6 signalling in the brain is associated with chronic inflammation resulting in neurodegeneration. Strawberry notch homolog 2 (Sbno2) is an IL-6-regulated gene whose function is largely unknown. Here we aimed to address this issue by investigating the impact of Sbno2 disruption in mice with IL-6-mediated neuroinflammation. Methods Mice with germline disruption of Sbno2 (Sbno2−/−) were generated and crossed with transgenic mice with chronic astrocyte production of IL-6 (GFAP-IL6). Phenotypic, molecular and transcriptomic analyses were performed on tissues and primary cell cultures to clarify the role of SBNO2 in IL-6-mediated neuroinflammation. Results We found Sbno2−/− mice to be viable and overtly normal. By contrast GFAP-IL6 × Sbno2−/− mice had more severe disease compared with GFAP-IL6 mice. This was evidenced by exacerbated neuroinflammation and neurodegeneration and enhanced IL-6-responsive gene expression. Cell culture experiments on primary astrocytes from Sbno2−/− mice further showed elevated and sustained transcript levels of a number of IL-6 stimulated genes. Notably, despite enhanced disease in vivo and gene expression both in vivo and in vitro, IL-6-stimulated gp130 pathway activation was reduced when Sbno2 is disrupted. Conclusion Based on these results, we propose a role for SBNO2 as a novel negative feedback regulator of IL-6 that restrains the excessive inflammatory actions of this cytokine in the brain.

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Section: Discussionmentioning

confidence: 99%

Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system

Syme

Grill

Hayashida

et al. 2022

J Neuroinflammation

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“…Previous reports have suggested that the Strawberry notch (sbno) gene of the fly is a component of the Notch signaling pathway, which includes the phenotype of multiple morphological abnormalities, such as notched wings and strawberry‐shaped, disorganized compound eyes (Coyle‐Thompson & Banerjee, 1993; Majumdar et al, 1997; Tsuda et al, 2002). These morphological phenotypes in the wings and eyes of Drosophila mutants are consistent with the abnormalities observed in Notch signaling mutants (Coyle‐Thompson & Banerjee, 1993). Notch and sbno are required for cone cell differentiation in ommatidia development in Drosophila , and sbno and Su(H), a Notch signaling DNA‐binding transcription factor, form a protein complex that activates the expression of Delta (Tsuda et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports have suggested that the Strawberry notch (sbno) gene of the fly is a component of the Notch signaling pathway, which includes the phenotype of multiple morphological abnormalities, such as notched wings and strawberry-shaped, disorganized compound eyes (Coyle-Thompson & Banerjee, 1993;Majumdar et al, 1997;Tsuda et al, 2002). These morphological phenotypes in the wings and eyes of Drosophila mutants are consistent with the abnormalities observed in Notch signaling mutants (Coyle-Thompson & Banerjee, 1993). Notch and sbno are required for cone cell differentiation in ommatidia development in Drosophila, and sbno and Su(H), a Notch signaling DNA-binding transcription factor, form a protein complex that activates the expression of Delta (Tsuda et al, 2002).…”

Section: Involvement Of Sbno1 In Notch Signalingmentioning

confidence: 99%

“…Sbno1 is one of the vertebrate homologues of the Drosophila gene Strawberry notch ( sbno ). sbno mutants exhibit notched wings and disorganized eyes, resembling a strawberry (Coyle‐Thompson & Banerjee, 1993). In addition, sbno shares abnormalities with Notch signaling‐related mutants (Coyle‐Thompson & Banerjee, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…sbno mutants exhibit notched wings and disorganized eyes, resembling a strawberry (Coyle‐Thompson & Banerjee, 1993). In addition, sbno shares abnormalities with Notch signaling‐related mutants (Coyle‐Thompson & Banerjee, 1993). Because Notch overexpression rescued some morphological abnormalities, sbno was suggested to be a downstream factor of Notch.…”

Section: Introductionmentioning

confidence: 99%

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Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons

et al. 2022

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When the regulation of axonal and dendritic growth is altered, the neuronal network becomes disordered, which may contribute to the development of psychiatric disorders. Some genome analyses have suggested relationships between mutations in strawberry notch homologue 1 (SBNO1) and neurodevelopmental disorders. However, the function of SBNO1 has not yet been reported. Here, SBNO1 expression pattern during the development of the cerebral cortex in mice was examined. SBNO1 was strongly expressed in the cortical plate and its expression was maintained at a low level during the postnatal stage. CRISPR/Cas9‐based knockout of Sbno1 in Neuro2A cultured cells showed delayed growth of neurites. A cortical neuron‐specific conditional knockout mouse was constructed, which resulted in hypotrophy of axon bundles and dendrites in cortical neurons. Thus, when mutated, SBNO1 is a candidate gene for psychiatric diseases, such as schizophrenia, as suggested by human genome studies.

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Expression ofstrawberry notchfamily genes during zebrafish embryogenesis

Takano

Zochi

Hibi³

et al. 2010

Developmental Dynamics

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Our previous study suggested a possible role for Sbno1, a mouse homologue of strawberry notch gene during brain development. In this report, we cloned the zebrafish homologues of sbno, and examined their expression pattern during embryogenesis by whole-mount in situ hybridization. Zebrafish have three sbno genes: one Sbno1 homologue and two Sbno2 homologues, sbno2a and sbno2b. We observed that the expression of sbno1 and sbno2a was initially ubiquitous and gradually became predominant in the central nervous system as development progressed. The expression of sbno2b was observed in non-neural tissues in contrast to the other two genes. sbno1 and sbno2a exhibited higher expression in distinct regions within the nervous system of pharyngula-stage embryos, suggesting possible differing roles for sbno1 and sbno2a during later stages of embryogenesis. Together, the observed gene expression patterns suggest an important role of sbno-family genes during development of the vertebrate central nervous system.

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The strawberry notch gene functions with Notch in common developmental pathways

Cited by 42 publications

References 62 publications

Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system

Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system

Involvement of strawberry notch homologue 1 in neurite outgrowth of cortical neurons

Expression ofstrawberry notchfamily genes during zebrafish embryogenesis

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