The I131-triolein absorption test

Use of unabsorbed radioactive marker substances in a re-assessment of the radioactive triolein test of fat absorption

“…They suggested that after the oral administration of labelled fat an index ofabsorption could be obtained from a measurement of either the subsequent blood radioactivity curve or the amount of unabsorbed radioactivity in the faeces. After initial enthusiasm (Baylin, Sanders, Isley, Shingleton, Hymans, Johnston, and Ruffin, 1955;Ruffin, Shingleton, Baylin, Hymans, Isley, Sanders, and Sohmer, 1956;Ruffin, Keever, Chears, Shingleton, Baylin, Isley, and Sanders, 1958) the use of the blood curve has been rejected by most investigators because its peak and shape were shown to be influenced by factors other than that due to fat absorption (Isley, Sanders, Baylin, Sharpe, Hymans, Ruffin, Shingleton, and Wilson, 1957;Mohamed and Hume, 1959;and Vidinli, Texter, and Cooper, 1963). More recently, the use of the measurement of faecal radioactivity after oral administration of labelled fat has also fallen into disrepute, chiefly because several workers found inconsistent correlation with chemical faecal fat estimation (eg, Pimparkar, Tulsky, Kalser, and Bockus, 1960;Cox, 1961;Clark, Crooks, Dawson, and Mitchell, 1964).…”