The IASLC Lung Cancer Staging Project: Proposals Regarding the Relevance of TNM in the Pathologic Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the TNM Classification for Lung Cancer

Vallières, Eric; Shepherd, Frances A.; Crowley, John; Houtte, Paul Van; Postmus, Pieter E.; Carney, Desmond N.; Chansky, Kari; Shaikh, Zeba; Goldstraw, Peter

doi:10.1097/jto.0b013e3181b27799

Cited by 440 publications

(320 citation statements)

References 39 publications

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“…To our knowledge, only a few articles reported that age was the independent prognostic factors for pulmonary NET (Filosso et al, 2014), which was likely attributable to the good immunity and resistance to the illness of young patients. TNM staging was also effective in predicting the outcome of pulmonary NET, similar to what Vallieres E reported (Vallieres et al, 2009) However, it was strange that nodal status did not predict the prognosis. A previous report showed that lymph node sampling might be inaccurate in evaluating the nodal status (Massard et al, 2006).…”

Section: Discussionsupporting

confidence: 62%

“…In this study, in order to compare the clinical, pathological and prognostic differences between different types of pulmonary NET, we used the 7th edition of American Joint Committee On Cancer/Union For International Cancer Control (AJCC/UICC) TNM staging system (Edge et al, 2010). The reason for applying the TNM staging system was chiefly on the basis of two large-scale surveys on carcinoid tumors and SCLC from International Associational Association for the Study of Lung Cancer (IASLC) database (Travis et al, 2008;Vallieres et al, 2009). OS was the main endpoint of this study.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

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Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Hu²,

Sun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 62%

Section: Diagnosis and Stagingmentioning

confidence: 99%

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Hu²,

Sun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Lung cancer was ultimately diagnosed in 11 of the participants, including two cases with pulmonary hilus enlargements. According to the latest Seventh Edition of the TNM Classification for Lung Cancer [16], 10 patients (90.91 %) were in stage I, comparing with one (9.09 %) in a status of liver metastasis. Figure 1 showed a patient with a 15-mm noncalcified nodule in the baseline DR scan, and the following surgery confirmed a diagnosis of adenocarcinoma.…”

Section: The Scoring Questionnaire and Demographics Characteristics Omentioning

confidence: 99%

Early Lung Cancer Detection Using the Self-Evaluation Scoring Questionnaire and Chest Digital Radiography: A 3-Year Follow-up Study in China

et al. 2012

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The standard definition of high-risk individuals for lung cancer was not uniform and the value of chest digital radiography (DR) in lung cancer screening was still unproven. The aim of this study was to assess whether the original questionnaire named as "Self-evaluation Scoring Questionnaire for High-risk Individuals of Lung Cancer" combined with DR examinations could detect early stage of lung cancer effectively. The Self-evaluation Scoring Questionnaire for High-risk Individuals of Lung Cancer had been designed in previous studies. Subjects with scores over 116 points were regarded as high-risk individuals and underwent the current DR scans at least once a year from 2007 to 2009. Noncalcified nodules with a diameter over 30 mm, along with enlarged pulmonary hilus and atelectasis, were considered to be positive and subjected to further special examinations. Efficacy of the scoring questionnaire combined with DR scans was estimated by 3-year results. Among 1,537 subjects, 13, 11, and 7 were diagnosed with lung cancer in the first, second, J Digit Imaging (2013) 26:72-81 DOI 10.1007 and third year, respectively, indicating the detection rate of 2.02 % (31/1,537). In addition, 77.42 % (24/31) of the patients were in stage I and 51.61 % (16/31) were adenocarcinomas. For the 31 cases, 28 were defined as detected cancers, while the other three were interval ones, only accounting for 0.20 % (3/1,504) of individuals with negative judgments. The protocol of Self-evaluation Scoring Questionnaire for High-risk Individuals of Lung Cancer combined with DR scans is a cost-effective and safe approach to detect early stage of lung cancer.

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“…Mediastinal LN dissection was routinely performed; in some patients, for example T1 tumor in patients age >70 years, A LN sampling was done. LN stations were defined according to the IASLC classification (18). The N2 level included ipsilateral station 2-station 9, N1 level included ipsilateral station 10-station 14, N3 level included station 1, contralateral mediastinal LN, and hilar nodes.…”

Section: Patient Selectionmentioning

confidence: 99%

Impact of lymph node management on resectable non-small cell lung cancer patients

et al. 2017

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Results: The average number of dissected LNs was 22.7±12.8. Tumor recurrence was found in 51.3% and overall mortality was 43.3%. The number of dissected LNs was a prognostic factor for tumor recurrence [HR 0.98, 95% confidence interval (CI): 0.96-0.99]. There was a significant difference at the cut-pointed value of 11 dissected LNs for tumor recurrence (HR 2.22, 95% CI: 1.26-3.92). Dissection less than 11 nodes and less than 5 stations indicated a poor prognostic factor for tumor recurrence: for 3-4 stations (HR 3.01, 95% CI: 1.22-7.42) and for 1-2 stations (HR 1.96, 95% CI: 1.04-3.72). The positivity of dissected LNs was also a prognostic factor for tumor recurrence and overall mortality (HR 1.01, 95% CI: 1.01-1.02 and HR 1.01, 95% CI: 1.01-1.03, respectively).Conclusions: Eleven or more LN dissection with at least 5 stations influenced recurrent-free survival.Systematic LN dissection (SLND) should be performed not only to identify the positivity of dissected LNs but also to determine an accurate tumor nodal stage. A larger cohort should be further conducted to support these findings.

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The IASLC Lung Cancer Staging Project: Proposals Regarding the Relevance of TNM in the Pathologic Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the TNM Classification for Lung Cancer

Abstract: This analysis further strengthens our previous recommendation to use TNM staging for all SCLC cases.

Cited by 440 publications

References 39 publications

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Early Lung Cancer Detection Using the Self-Evaluation Scoring Questionnaire and Chest Digital Radiography: A 3-Year Follow-up Study in China

Impact of lymph node management on resectable non-small cell lung cancer patients

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