The iBerry study: a longitudinal cohort study of adolescents at high risk of psychopathology

Mil, Nina H. Grootendorst‐van; Bouter, Diandra C.; Hoogendijk, Witte J.G.; Jaarsveld, Stefanie F. L. M. van; Tiemeier, Henning; Mulder, Cornelis L.; Roza, Sabine J.

doi:10.1007/s10654-021-00740-w

Cited by 26 publications

(25 citation statements)

References 38 publications

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“…The total cohort consists of 1022 adolescents, oversampled on their emotional and behavioral problems (2.5:1 ratio). At baseline (mean age 15.0 years), adolescents showed apparent emotional and behavioral symptoms; 30.7% of the high-risk adolescents reported emotional or behavioral problems above the borderline cut-off, compared to 8.1% of the low-risk adolescents [24].…”

Section: Methodsmentioning

confidence: 99%

“…This study included two additional online questionnaires (C1 and C2, administered during the first and second nationwide lockdowns in April 2020 and January 2021, respectively) conducted within the iBerry (Investigating Behavioral and Emotional Risk in Rotterdam Youth) Study. The iBerry Study started in September 2015 and the study cohort has been described in detail previously [24]. In short, the iBerry Study is a population-based cohort study of adolescents designed to investigate the transition from subclinical symptoms to a psychiatric disorder.…”

Section: Methodsmentioning

confidence: 99%

“…A cohort of high-risk adolescents was selected based on their self-reported emotional and behavioral symptoms experienced in the first year of high school (mean age 13.1 years). Each adolescent filled out the youth version of the Strengths and Difficulties Questionnaire (SDQ-Y), and adolescents with the highest 15% of scores and a random sample from the lowest 85% of scores were selected [24,25]. The total cohort consists of 1022 adolescents, oversampled on their emotional and behavioral problems (2.5:1 ratio).…”

Section: Methodsmentioning

confidence: 99%

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A longitudinal study of mental health in at-risk adolescents before and during the COVID-19 pandemic

Bouter

Zarchev

Neve-Enthoven

et al. 2022

Eur Child Adolesc Psychiatry

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Although cross-sectional studies have shown that the COVID-19 pandemic has negatively affected the mental health of adolescents, the effect of the pandemic on adolescents with pre-pandemic symptoms is unclear. We, therefore, tested the hypothesis that adolescents had increased emotional and behavioral problems during the lockdowns imposed during the pandemic.This study included three measurements in a prospective cohort of 1022 adolescents who were oversampled based on their high risk of developing psychopathology. Before the pandemic, we assessed depressive, anxiety, stress, oppositional defiant problems, psychotic experiences and suicidality, using the Youth Self-Report; 445 and 333 of these 1,022 adolescents subsequently completed the online questionnaire in the first lockdown (in April 2020) and in the second lockdown (in January 2021), respectively. Multilevel random intercept regression models were used to determine the change in psychiatric symptoms, including an interaction term to assess whether these changes differed based on the severity of symptoms prior to the pandemic. Throughout the pandemic, the majority of the participating adolescents reported having emotional and behavioral symptoms that were within the normal range. Moreover, the mean symptom scores for all six outcomes decreased significantly among adolescents with high clinical severity prior to the pandemic.In contrast to our original hypothesis, the effects of the COVID-19 pandemic may not necessarily be detrimental, at least among a specific subgroup of adolescents with pre-existing mental health problems. Moreover, our finding that most adolescents in this at-risk sample did not report experiencing clinically relevant symptoms during the pandemic reflects their resilience during the pandemic.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A longitudinal study of mental health in at-risk adolescents before and during the COVID-19 pandemic

Bouter

Zarchev

Neve-Enthoven

et al. 2022

Eur Child Adolesc Psychiatry

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“…Ultimately, the response rate of 45.1% in the MILE-STONE cohort is similar to response rates in other cohort studies on adolescents with mental health problems. [17][18][19] Additionally, even though there are indications of selective drop-out, the proportion of young people that withdrew in the 24-month follow-up period was low. A possible selection bias and selective drop-out may affect the representativeness of the MILESTONE cohort, but a representative sample may not be required to generalise the Open access findings from MILESTONE cohort to other clinical populations of young people in the transition age.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Cohort profile: demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe

Gerritsen¹,

Maras²,

Bodegom³

et al. 2021

BMJ Open

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PurposeThe presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports.ParticipantsSeven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at.Findings to dateThis cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be ‘markedly ill’, ‘severely ill’ or ‘among the most extremely ill’ by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year.Future plansAnalysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared.Trial registration numberNCT03013595.

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“…The limitations with regard to the recruitment process, representativeness, and generalizability were elaborately discussed in a paper describing the cohort profile [11] and will be discussed only briefly in this paper. First, a selection bias may exist due to several reasons: the selection of CAMHS participating in MILESTONE were not made randomly, but should be considered a convenience sample, the response rate was 45.1% (although other cohort studies on adolescents with mental health problems report similar response rates [27][28][29]) and the proportion of missing information, particularly among parents, is considerable. The response rate of 45.1% may be an overestimation of the true response rate that we would have obtained if information on the recruitment process was complete, but this estimate most accurately reflects the process.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services

Gerritsen

Bodegom²,

Dieleman³

et al. 2022

Soc Psychiatry Psychiatr Epidemiol

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Purpose The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.

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The iBerry study: a longitudinal cohort study of adolescents at high risk of psychopathology

Cited by 26 publications

References 38 publications

A longitudinal study of mental health in at-risk adolescents before and during the COVID-19 pandemic

A longitudinal study of mental health in at-risk adolescents before and during the COVID-19 pandemic

Cohort profile: demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe

Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services

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