Thought disorder as well as language and communication disturbances are associated with schizophrenia and are over-represented in clinically unaffected relatives of schizophrenics. All three kinds of dysfunction involve some element of deviant verbalizations, most notably, semantic anomalies. Of particular importance, thought disorder characterized primarily by deviant verbalizations has a higher recurrence in relatives of schizophrenic patients than schizophrenia itself. These findings suggest that deviant verbalizations may be more penetrant expressions of schizophrenia susceptibility genes than schizophrenia. This paper reviews the evidence documenting the presence of thought, language and communication disorders in schizophrenic patients and in their first-degree relatives. This familial aggregation potentially implicates genetic factors in the etiology of thought disorder, language anomalies, and communication disturbances in schizophrenia families. We also present two examples of ways in which thought, language and communication disorders can enrich genetic studies, including those involving schizophrenia.
KeywordsSchizophrenia; Thought disorder; Language disorders; Communication disorders; Semantic anomalies; Genetics; Family studies; Linkage analyses; Endophenotypes
Thought Disorder and SchizophreniaDue largely to the influence of Eugen Bleuler (Bleuler, 1911(Bleuler, /1950, thought disorder was considered virtually pathognomonic of the diagnosis of schizophrenia for many years. Kraepelin (Kraepelin, 1896(Kraepelin, /1919 is not credited with having had as much influence as Bleuler Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript in this respect, but he too was impressed with the centrality of disturbed thinking in dementia praecox. Kraepelin considered "derailments in the train of thought," which he named "akataphasia," to be a fundamental characteristic of the dementia of dementia praecox (Kraepelin, 1896(Kraepelin, /1919. Manifestations of derailment included loosening of associations ("the most different ideas follow one another with most bewildering want of connection..." p. 56) and incoherence ("bewilderingly nonsensical utterances ... apparently represent a senseless jiggling of words" p. 71). 1 Bleuler (Bleuler, 1911(Bleuler, /1950) considered "disorders of association" to be one of the four fundamental characteristics of the schizophrenias. He relegated the more conspicuous psychotic indicators, delusions and hallucinations, to secondary status as "acce...