BackgroundExpansion of the aesthetic treatment armamentarium with novel injectable products has greatly improved our ability to reshape and enhance the facial profile. However, full‐face “profiloplasty” with injectables remain a nascent concept and is insufficiently considered in daily practice. While techniques have been widely published for treating the individual facial areas that constitute an attractive profile—including the forehead, nose, lips, jawline, and chin—the literature remains fragmented on more universal methods for profile improvement.AimsTo collate disparate knowledge on profile optimization with injectables, and define a holistic, practical, and user‐friendly approach to profiloplasty and facial contouring.MethodsConsideration is given to key anatomical aspects and the changes that occur with age; patient assessment parameters for planning profiloplasty; and the technical specifications, product selection, and essential safety considerations for minimizing the risk of complications and optimizing the effectiveness of treatment.ResultsRelevant case studies are presented.ConclusionsHolistic approaches of this type are essential if we are to maximize the potential of full‐face treatment with injectables—both now and in the future.