The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico

Martínez‐Magaña, José Jaime; Genis‐Mendoza, Alma Delia; Velázquez, Jorge Ameth Villatoro; Camarena, Beatríz; Sánchez, Rubén Argüero; Fleiz, Clara; Gamiño, Marycarmen Bustos; Reséndiz, Esbehidy; Aguilar, Alejandro; Medina‐Mora, María Elena; Nicolini, Humberto

doi:10.3389/fphar.2020.00324

Cited by 11 publications

(7 citation statements)

References 68 publications

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“…Hispanic patients in our cohort where mainly from Mexico. Mexicans have a heterogeneous genetic admixture by their region and evaluating genetic admixtures would improve our study [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia

Wang

Alqahtani

et al. 2022

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 99%

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia

Wang

Alqahtani

et al. 2022

Biomedicine & Pharmacotherapy

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“…A remarkable intrapopulation diversity has been observed in the Native Americans, supporting the results found in this review [ 37 , 52 ]. Likewise, the genetic wealth of contemporary Native Americans, in conjunction with the several admixture degrees in their non-Native American populations, makes the Americas an excellent candidate for pharmacogenetic studies [ 39 , 49 , 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

et al. 2023

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Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer susceptibility; its protein structure and acetylation capacity results from the polymorphism’s arrays on the NAT2 gene. Absorption, distribution, metabolism, and excretion, cornerstones of the pharmacological effects, have shown diversity patterns across populations, ethnic groups, and even interethnic variation. Although the 1000 Genomes Project database has portrayed the global diversity of the NAT2 polymorphisms, several populations and ethnicities remain underrepresented, limiting the comprehensive picture of its variation. The NAT2 clinical entails require a detailed landscape of its striking diversity. This systematic review spans the genetic and acetylation patterns from 164 articles from October 1992 to October 2020. Descriptive studies and controls from observational studies expanded the NAT2 diversity landscape. Our study included 243 different populations and 101 ethnic minorities, and, for the first time, we presented the global patterns in the Middle Eastern populations. Europeans, including its derived populations, and East Asians have been the most studied genetic backgrounds. Contrary to the popular perception, Africans, Latinos and Native Americans have been significantly represented in recent years. NAT2*4, *5B, and *6A were the most frequent haplotypes globally. Nonetheless, the distribution of *5B and *7B were less and more frequent in Asians, respectively. Regarding the acetylator status, East Asians and Native Americans harboured the highest frequencies of the fast phenotype, followed by South Europeans. Central Asia, the Middle East, and West European populations were the major carriers of the slow acetylator status. The detailed panorama presented herein, expands the knowledge about the diversity patterns to genetic and acetylation levels. These data could help clarify the controversial findings between acetylator states and the susceptibility to diseases and reinforce the utility of NAT2 in precision medicine.

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“…Mixing of populations resulting in genetic admixtures is an important process in evolution [1] as it is one of the fastest evolutionary processes to affect the genetic structure of a population [2] and have been observed in many species; including, human [3], fish [4], cat [5], cattle [6], and moth [7]. This can lead to a rapid genetic diversification, which may result in rapid reduction of detrimental mutation load [8], improved health [9,10], and disease resistance [11]. There are many recent studied examples of human population admixtures [12][13][14]; including, Denisovans and Neanderthals leading to Asian population [15], hunter-gatherers and Neolithic farmers in Iron Age Europe [16], northern and southern China [17], Latin America [18], and the entire Asia at large [19].…”

Section: Introductionmentioning

confidence: 99%

Novel Populations from Simulated Admixed Populations

2022

MCMS

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Admixtures of two relatively distinct populations; as a result of clashing, mixing, and merging; can drastically affect its population genetics. Studies have suggested that admixed populations are instrumental in establishing novel populations. Computer simulations is a common method to study population admixtures. Although it is plausible to study the emergence of novel populations from simulated admixed populations, studies in this area have been sparse. Here, we attempt to demonstrate the emergence of novel populations from admixed populations using simulation. Our results show that all admixed populations have the potential to result in the emergence of novel populations despite large majority (up to 90%) of one of the two source populations. The null hypothesis of no significant allelic changes can be rejected with a p-value of 5.3E-05. Therefore, our simulation study supports current studies suggesting that admixed populations are instrumental in establishing novel populations.

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The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico

Cited by 11 publications

References 68 publications

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia

Hispanic ethnicity and the rs4880 variant in SOD2 are associated with elevated liver enzymes and bilirubin levels in children receiving asparaginase-containing chemotherapy for acute lymphoblastic leukemia

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

Novel Populations from Simulated Admixed Populations

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