“…The EI-MS spectrum [m/z: 411(M + )] corresponded to a molecular formula of C 29 H 48 O. This led us to propose that compound 1 was fucosterol (Komura et al, 1974;Lee et al, 2003). The compound 2 from fraction B has FTIR absorption peaks at 3409 and cm −1 which supports the presence of hydroxyl group.…”
Lagenaria siceraria (Molina) Standl in the Cucurbitaceae family is a large, pubescent, climbing, or trailing herb cultivated throughout India and the tropical regions of the world. Phytochemical investigation of the methanol extract obtained from the fruits of the plant L. siceraria showed a positive Liebermann-Burchard test for sterols. The white sterol crystals or phytosterols from the methanol extract were isolated for the first time and identified as a mixture of four sterols, including fucosterol (1), racemosol (2), stigmasterol (3), and stigmasta-7,22-dien-3β,4β-diol (4). These compounds were identified by spectroscopic evidence including FTIR, (1)H-NMR, MS, and GC. The white sterol crystals, which are the mixture of four sterols, were evaluated for antihyperlipidemic activity in Wistar rats. The blood samples were collected from the retro-orbital plexus and serum was separated and analyzed for lipid profiles. These sterol crystals (30 mg/kg) showed significant reductions in lipid profiles which included cholesterol, triglycerides, LDL and VLDL. In addition, a significant increase in HDL cholesterol observed, which is a good cholesterol that protects hearts from coronary artery diseases. These sterol crystals or phytosterols can be used as an antihyperlipidemic agent to treat the hyperlipidemic.
“…The EI-MS spectrum [m/z: 411(M + )] corresponded to a molecular formula of C 29 H 48 O. This led us to propose that compound 1 was fucosterol (Komura et al, 1974;Lee et al, 2003). The compound 2 from fraction B has FTIR absorption peaks at 3409 and cm −1 which supports the presence of hydroxyl group.…”
Lagenaria siceraria (Molina) Standl in the Cucurbitaceae family is a large, pubescent, climbing, or trailing herb cultivated throughout India and the tropical regions of the world. Phytochemical investigation of the methanol extract obtained from the fruits of the plant L. siceraria showed a positive Liebermann-Burchard test for sterols. The white sterol crystals or phytosterols from the methanol extract were isolated for the first time and identified as a mixture of four sterols, including fucosterol (1), racemosol (2), stigmasterol (3), and stigmasta-7,22-dien-3β,4β-diol (4). These compounds were identified by spectroscopic evidence including FTIR, (1)H-NMR, MS, and GC. The white sterol crystals, which are the mixture of four sterols, were evaluated for antihyperlipidemic activity in Wistar rats. The blood samples were collected from the retro-orbital plexus and serum was separated and analyzed for lipid profiles. These sterol crystals (30 mg/kg) showed significant reductions in lipid profiles which included cholesterol, triglycerides, LDL and VLDL. In addition, a significant increase in HDL cholesterol observed, which is a good cholesterol that protects hearts from coronary artery diseases. These sterol crystals or phytosterols can be used as an antihyperlipidemic agent to treat the hyperlipidemic.
“…Fucosterol seems to be one of the main components of algal tissues (e.g. Komura, 1974). Figure 6. Algal signature: (a) partial chromatogram of the polar fraction of the sample of the alga Fucus vesiculosus and mass spectrum of the fucosterol peak; (b) chromatogram of the aliphatic fraction of the sample of the alga Enteromorpha intestinalis , showing the n -alkane distribution.…”
AbstractThe composition of the soluble organic matter of the Oxfordian–Kimmeridgian Flodigarry Shale Member (Isle of Skye, Scotland) is presented for the first time. A continuous succession of silty clays and nodular limestone beds is exposed on a rocky shore to the north of Staffin Bay. This succession is proposed as a potential stratotype of the boundary between the Oxfordian and Kimmeridgian stages. This paper points out the exceptional preservation and very low thermal degradation of the organic matter. Indeed, the molecular composition is characterized by the abundance of unsaturated biomarkers (hopenes and diasterenes) as well as undamaged bioterpenoids (ferruginol and sugiol). The abundance of long-chainn-alkanes characterized by an odd-over-even predominance reveals a dominant continental contribution. This is also attested to by the relatively high amounts of plant biomarkers (e.g. ferruginol, sugiol, cadalene and retene), which suggest a palaeovegetation largely composed of pinophytes, especially Cupressaceae, Taxodiaceae and Cheirolepidiaceae, on the nearest emerged lands. The water column of the depositional environment was oxic in its upper part and rather dysoxic in its lower part. The composition of the organic matter does not significantly change along the Flodigarry Shale Member. In other words, no evolutionary events or drastic change in palaeoenvironments can be deduced from the molecular content of these sedimentary rocks, and it does not allow us to support a precise location for the Oxfordian/Kimmeridgian boundary in the succession.
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