The IL-1β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation

Aparicio, J. Paz; Bances, I. Fernández; Fernández, Erika; Montes, A. Hugo; Aparicio, Andrea; Vázquez, J. Pena; Garcia, Sergi; García, Sandra Sánchez; Fernández, P. López; Valle-Garay, Eulalia; Asensi, Vı́ctor

doi:10.1007/s00586-011-1915-2

Cited by 39 publications

(35 citation statements)

References 24 publications

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“…Moreover, the population studied by us in Mexico has a particular genetic background, since half of the most common haplotypes found in this population have a proposed European origin, most likely from Spanish origin [ 52 ]. Not surprisingly, the frequency of the T allele in our population (28.0%) was similar to the one observed in a Spanish population (35.5%) [ 49 ] and alike our results was not associated with IDD.…”

Section: Resultssupporting

confidence: 90%

“…A study of a Danish population also found an association of this polymorphism with disc degeneration [ 39 ]. In contrast, a case-control study of a population of Spain found no association between T allele and symptomatic lumbar disc herniation [ 49 ]. The reason for this inconsistent association between the T allele and IDD may be due to ethnic differences in the studied populations, or by different haplotypes in the promoter or enhancer regions.…”

Section: Resultsmentioning

confidence: 99%

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Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Serrano

Villareal

Aguilar‐Medina

et al. 2014

International Journal of Genomics

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Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD (n = 100) and subjects with normal lumbar-spine MRI-scans (n = 100). Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% (P = 0.455) for T of rs1800587 (IL1A); 53.0% versus 58.0% (P = 0.183) for V of rs2228570 (VDR); and 18.0% versus 21.0% (P = 0.262) for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Serrano

Villareal

Aguilar‐Medina

et al. 2014

International Journal of Genomics

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“…1,10,15,22 Increasing polymorphisms in gene encoding for these factors have been reported in lumbar disc diseases and LBP, and, in particular, the SNP of IL-1b may confer susceptibility to LBP. 11,18,20,25 Caspase-9 is an initiator caspase protease for apoptosis, and recent studies have indicated that it plays a significant role in apoptosis in human intervertebral disc degeneration. 17,19 Caspase-9 polymorphism has been reported to be associated with the susceptibility to discogenic LBP.…”

Section: ©Aans 2013mentioning

confidence: 99%

Analysis of association between IL-1β, CASP-9, and GDF5 variants and low-back pain in Chinese male soldiers

Zuo³

et al. 2013

SPI

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Object Recent studies have suggested that genetic risk factors play an important role in the occurrence of low-back pain (LBP) and lumbar disc disease. The authors' study aimed to assess the association between 3 single-nucleotide polymorphisms (SNPs) and susceptibility to LBP related to military training. Methods In this case-control study, data from 892 Chinese male soldiers were retrospectively reviewed. The case group was made up of 305 soldiers with LBP related to military training and a control group of 587 soldiers without constant LBP for more than 2 weeks. Genomic DNA was extracted from peripheral blood leukocytes of all subjects and polymerase chain reaction products were genotyped. Results No association was found between the SNP of interleukin-1β (IL-1β; +3954C/T) and LBP at both the genotypic (p = 0.104) and the allelic (p = 0.098) level. However, the G allele of caspase-9 (CASP-9) and the T allele of growth differentiation factor 5 (GDF5) were more common in patients with LBP than in patients without LBP (p < 0.001). Conclusions The findings in a Chinese military cohort indicated that CASP-9 (−1263A/G) and GDF5 (+104T/C) polymorphisms are associated with a susceptibility to LBP related to military training.

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“…Genotypes were determined by PCR-RFLP using a Hightech Thermocycler Cycler-Technology for Life (SensoQuest, Gottingen, Germany). Protocols for -889T>C IL-1α, -31T>C and -511C>T IL-1β, -330 T>G IL-2 and -174 G>C IL-6 polymorphisms followed previously described PCR-RFLP techniques (Todhunter et al, 2005;Gao, 2009;Paz Aparicio et al, 2011;September et al, 2011) (see Table 1).…”

Section: Methodsmentioning

confidence: 99%

Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β, IL-2 and IL-6 in subjects over 55 years old.

et al. 2016

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The IL-1β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation

Cited by 39 publications

References 24 publications

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration

Analysis of association between IL-1β, CASP-9, and GDF5 variants and low-back pain in Chinese male soldiers

Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β, IL-2 and IL-6 in subjects over 55 years old.

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