The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer

Martínez-Pérez, Carlos; Kay, Charlene; Meehan, James; Gray, Mark; Dixon, JM; Turnbull, Arran

doi:10.3390/jpm11111073

Cited by 13 publications

(10 citation statements)

References 334 publications

(428 reference statements)

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“…This result was consistent with our previous studies showing that the interaction of IL‐2 and IL‐2R across humans and pigs might have defects 61 . Inflammatory factors IL‐6 and IL‐31 can be expressed and secreted by many kinds of immune cells and are major pro‐inflammatory factors 62,63 . The low compatibilities between human and pig IL‐6 and IL‐31 indicated their limited effectiveness on xenogeneic cells.…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, these dissimilar genes should be paid attention to avoid coagulation disorders in human and pig xenogeneic combination settings. There are several important studies reporting the function similarities or dissimilarities of related proteins between humans and pigs, which are summarized with their sequence similarities and domain composition consistency identified in the present study [20][21][22][61][62][63][68][69][70][71][72][73][74][75][76][77][78][79][80] (Table 1).…”

Section: Compatibility Of Hematopoiesis-related Genes Between Humans ...mentioning

confidence: 85%

“…61 Inflammatory factors IL-6 and IL-31 can be expressed and secreted by many kinds of immune cells and are major proinflammatory factors. 62,63 The low compatibilities between human and pig IL-6 and IL-31 indicated their limited effectiveness on xenogeneic cells. However, the in vitro observations demonstrated that human and pig IL-6 can activate the IL-6/IL-6Rα/STAT3 pathway in human and pig cells.…”

Section: Compatibility Of Hematopoiesis-related Genes Between Humans ...mentioning

confidence: 99%

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Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs

Zhang

et al. 2022

Xenotransplantation

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The shortage of allogeneic donor organs leaves its supply far short of clinical need.There are great expectations on xenotransplantation, especially with pigs' organs. With the genetic modification of donor pigs, the rejection and cross-species transmission issues have now been widely addressed. However, research on the compatibility of genes between humans and pigs was limited. We performed a systematic screening analysis of predicted incompatible genes between humans and pigs, judged by low protein sequence similarities or different predicted protein domain compositions. By combining with gene set enrichment analysis, we screened out several key genes of hematopoiesis and the immune system with possible incompatibilities, which might be important for establishing chimera and xenotransplantation between humans and pigs.There were seven chemokine genes, including CCL1, CCL5, CCL24, CCL25, CCL28, CXCL12, and CXCL16, that exhibited limited similarity between humans and pigs (similarity < 0.8). Among hematopoiesis process-related genes, 15 genes of adhesion molecules, Notch ligands, and cytokine receptors exhibited differences between humans and pigs. In complement and coagulation cascades, 19 genes showed low similarity and 77 genes had different domain compositions between humans and pigs. Our

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Section: Discussionsupporting

confidence: 92%

Section: Compatibility Of Hematopoiesis-related Genes Between Humans ...mentioning

confidence: 85%

Section: Compatibility Of Hematopoiesis-related Genes Between Humans ...mentioning

confidence: 99%

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Bioinformatic analysis as a first step to predict the compatibility of hematopoiesis and immune system genes between humans and pigs

Zhang

et al. 2022

Xenotransplantation

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“…Предполагается, что такая активность IL6 может приводить к постепенному разрушению β-клеток поджелудочной железы [10]. IL-6 передает сигналы через комплекс рецепторов цитокинов 1-го типа на клеточной мембране, состоящей из лиганд-связывающей цепи IL-6Rα (CD126) и компонента, передающего сигналы gp130 (также называемый CD130) [11,12]. Возможно, что IL-6 обладает и противовоспалительным действием, которые, скорее всего, обусловлены его классической передачей сигналов (через аналогичные белки, связанные с мембраной).…”

Section: оригинальная статьяunclassified

The pathogenic role of IL6 gene polymorhisms in type 1 diabetes mellitus

Иванова¹,

Бурденный²,

Логинов³

et al. 2022

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Актуальность. Сахарный диабет типа 1 (ранее называемый ювенильным или инсулинозависимым) характеризуется тем, что продукция инсулина отсутствует вследствие аутоиммунной деструкции клеток поджелудочной железы, вероятно, вызванной действием факторов внешней среды на фоне генетической предрасположенности, которая проявляется в наличии функциональных однонуклеотидных замен (SNP) в генах цитокинов, ответственных за воспаление. Считается, что при длительном хроническом воспалении происходит необратимое разрушение β-клеток поджелудочной железы, и при наличии функциональных полиморфных маркёров в генах воспаления, таких как ген интерлейкин β (IL6), возможна манифестация болезни с последующей прогрессией и развитием осложнений. Цель исследования - изучение частоты распределения аллелей и генотипов ряда полиморфных маркёров гена IL6 при СД типа 1 у жителей Москвы и Московской области. Методика. В настоящую работу включено 366 больных СД типа 1 и 526 здоровых индивидов. Группу больных составили пациенты с наличием сахарного диабета типа 1 различной манифестации с общей медианой возраста 41±5 лет. Обе группы выравнены по полу и возрасту. Определение генотипов полиморфных маркёров rs1800795, rs1800796, rs1800797 и rs1554606 гена IL6 проводилось с помощью ПЦР «в реальном времени» на амплификаторе «Real-time CFX96 Touch» (Bio-Rad, США) с использованием готовой смеси для ПЦР qPCRmix-HS (Евроген, Россия) и уникальных праймеров и зондов. Результаты. В результате исследования выявлена статистически значимая ассоциация полиморфного маркёра rs1800795 гена IL6 с повышенным риском развития СД1 (χ2=9,48, OR=1,35, CI95%=1,11-1.64, р=0,0088). Заключение. Полученные результаты дополняют информацию о механизмах возникновения и патогенезе СД типа 1. Внедрение в практику анализа полиморфных вариантов гена IL6, позволит выявить вероятность развития этой болезни и/или её прогрессирование у пациентов с аутоиммунными заболеваниями или у лиц, находящихся в группе риска. Background. Type 1 diabetes mellitus (T1DM), previously called juvenile or insulin-dependent diabetes, is characterized by lack of insulin production due to autoimmune destruction of pancreatic cells. This destruction may be caused by environmental factors. These factors contribute to inflammation in the presence of genetic predisposition due functional single nucleotide polymorphisms (SNPs) in the cytokine genes. It is supposed that during prolonged chronic inflammation, irreversible destruction of all pancreatic b-cells occurs. In the presence of functional, polymorphic markers in inflammatory genes, such as the interleukin 6 (IL6) gene, the manifestation and progression of T1DM is possible, followed by complications. Aim. The aim of the present study was to define the frequency distribution of allelic variants and genotypes in a number of polymorphic markers of the IL6 gene in patients with T1DM residing in Moscow and the Moscow Region. Methods. The present study included 366 patients with T1DM and 526 healthy individuals. The T1DM group consisted of native Russian patients with T1DM of various manifestations and with a median age of 41 ± 5 yrs. The groups were gender- and age- matched. Genotypes of polymorphic markers rs1800795, rs1800796, rs1800797, and rs1554606 of the IL6 gene were determined using real-time PCR on a Real-time CFX96 Touch amplifier (Bio-Rad, USA) using qPCRmix-HS ready-mixed PCR kits (Eurogen, Russia) and unique primers and probes. Results. Our study revealed a statistically significant association of the polymorphic marker rs1800795 of the IL6 gene with an increased risk of developing T1DM (χ2=9.48, OR=1.35, CI95%=1.11-1.64, р=0.0088). Conclusion. Our results complement present information on the origin, mechanisms, and pathogenesis of T1DM. By implementing the analysis of polymorphic variants of IL6 gene in clinical practice, it will be possible to identify the probability of developing T1DM and/or its progression in patients with autoimmune diseases or in people at risk.

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“…Although biomarkers have been defined according to specific applications, biomarkers may also meet multiple criteria for different uses. Numerous papers contributed to this Special Issue deal with biomarkers that fall into this category, including studies involving colorectal [18] and breast [19][20][21] cancers.…”

mentioning

confidence: 99%