The image quality, lesion detectability, and acquisition time of 18F-FDG total-body PET/CT in oncological patients

Zhang, Yiqiu; Hu, Pengcheng; Wu, Runze; Gu, Yushen; Chen, Shuguang; Yu, Haojun; Wang, Xiangqing; Song, Jun Young; Shi, Hongcheng

doi:10.1007/s00259-020-04823-w

Cited by 97 publications

(74 citation statements)

References 14 publications

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“…Specifically, a PET system with a higher resolution can achieve a more accurate lesion location and efficient rejection of the events outside the region of interest. Moreover, shorter imaging time can greatly accelerate the examination time and reduce the pain of patients [ 4 ]. The performance of a PET system [ 5 , 6 , 7 , 8 , 9 ] directly depends on its components, which include a scintillation crystal, a photodetector, a readout circuit, etc.…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Deng

Chen

2020

Sensors

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Positron emission tomography (PET) has a wide range of applications in the treatment and prevention of major diseases owing to its high sensitivity and excellent resolution. However, there is still much room for optimization in the readout circuit and fast pulse sampling to further improve the performance of the PET scanner. In this work, a LIGHTENING® PET detector using a 13 × 13 lutetium-yttrium oxyorthosilicate (LYSO) crystal array read out by a 6 × 6 silicon photomultiplier (SiPM) array was developed. A novel sampling method, referred to as the dual time interval (DTI) method, is therefore proposed to realize digital acquisition of fast scintillation pulse. A semi-cut light guide was designed, which greatly improves the resolution of the edge region of the crystal array. The obtained flood histogram shown that all the 13 × 13 crystal pixels can be clearly discriminated. The optimum operating conditions for the detector were obtained by comparing the flood histogram quality under different experimental conditions. An average energy resolution (FWHM) of 14.3% and coincidence timing resolution (FWHM) of 972 ps were measured. The experimental results demonstrated that the LIGHTENING® PET detector achieves extremely high resolution which is suitable for the development of a high performance time-of-flight PET scanner.

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Section: Introductionmentioning

confidence: 99%

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Deng

Chen

2020

Sensors

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“…And its superior performance has made it a powerful tool in oncological applications. [18][19][27][28] The ultra-high sensitivity provides the feasibility of a fast PET scan in routine practice for an improvement of patient comfort and an increased throughput. This study assessed the image quality from the phantom and clinical perspectives to explore a fast PET scan protocol with consistent image quality to that in a routine digital PET scanner.…”

Section: Discussionmentioning

confidence: 99%

Total-body 18F-FDG PET Scan in Oncological Patients: How Fast could it be?

Zhang

et al. 2021

Preprint

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Purpose: The aim of the study was to explore a fast PET scan protocol of the total-body uEXPLORER scanner by assessing the image quality consistent to that of a conventional digital PET/CT scanner both from the phantom and clinical perspectives.Methods: The phantom study using a NEMA/IEC NU-2 body phantom was performed both on a total-body PET/CT (uEXPLORER) and a digital routine PET/CT (uMI 780), with hot sphere to background activity concentration ratio of 4:1. The contrast recovery coefficient (CRC), background variability (BV), recovery coefficient RCmax and RCmean were assessed and compared between that in uEXPLORER with the different scanning duration and reconstruction protocols and that in uMI 780 with clinical settings. The coefficient of variation (COV) of the uMI 780 with clinical settings were calculated and used as a threshold to determine the optimized scanning duration and reconstruction protocols were, which can provide a consistent image quality for the two scanners. And subsequently, the proposed protocol was validated by 30 oncological patients. Images acquired in uMI 780 with a 2-3 minute for each bed position were referred as G780. All PET raw data were reconstructed using data-cutting technique to simulate a 30s, 45s or 60s acquisition duration on uEXPLORER. The iterations were 2 and 3 for uEXPLORER, referred as G30s_3i, G45s_2i, G45s_3i, G60s_2i, and G60s_3i. A 5-point Likert scale was used in the qualitative analysis to assess the image quality. The image quality was also compared with the liver COV, the lesion target-to-background ratio (TBR), and the lesion signal-to-noise ratio (SNR).Results: In the phantom study, CRC, BV, RCmax and RCmean in uEXPLORER with different scanning duration and reconstruction iterations were compared with that in uMI 780 with clinical settings and a minor fluctuation was found among different scanning durations. COV of the uMI 780 with clinical settings was 11.6% and determined protocol with a 30-45s scanning duration and 2 or 3 iterations to provide a similar image quality.In the quantitative analysis on the clinical images, there was no significant difference between G780 and G45s_3i. All the other groups in uEXPLORER with a 45s- and above acquisition showed a significantly improved image quality than that in uMI 780 with clinical settings. Comparing the liver COV, there was no significantly difference between G780 and G30s_3i. And no significant difference in lesion TBR was identified between G780 and G45s_2i, while uEXPLORER had a better performance in lesion SNR compared to that in uMI 780 with clinical settings. Conclusions: This study demonstrated a fast PET protocol with a 30-45s acquisition in uEXPLORER with consistent image quality to that in uMI 780 with clinical settings.

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“…These claims were successfully demonstrated through a series of well-designed studies and publications over the last 2 years [4,[6][7][8][9][10][11]. Indeed, this state-of-the-art scanner possesses many advantages over previously developed PET/CT scanners.…”

mentioning

confidence: 94%

Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET

Lan

Fan

et al. 2021

Eur J Nucl Med Mol Imaging

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The image quality, lesion detectability, and acquisition time of 18F-FDG total-body PET/CT in oncological patients

Cited by 97 publications

References 14 publications

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Total-body 18F-FDG PET Scan in Oncological Patients: How Fast could it be?

Dynamic PET imaging with ultra-low-activity of 18F-FDG: unleashing the potential of total-body PET

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