2023
DOI: 10.3390/biomedicines11020329
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The Imbalance of Astrocytic Mitochondrial Dynamics Following Blast-Induced Traumatic Brain Injury

Abstract: Mild blast-induced traumatic brain injury (bTBI) is a modality of injury that has been of major concern considering a large number of military personnel exposed to explosive blast waves. bTBI results from the propagation of high-pressure static blast forces and their subsequent energy transmission within brain tissue. Exposure to this overpressure energy causes a diffuse injury that leads to acute cell damage and, if chronic, leads to detrimental long-term cognitive deficits. The literature presents a neuro-ce… Show more

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Cited by 10 publications
(10 citation statements)
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“…In the hippocampal PTE + vs. PTE − comparison, enrichment terms suggested alterations in mitochondrial function and cellular metabolism, as has been reported in blast injury in several recent studies [ 24 , 25 , 26 , 27 ]. To further investigate processes related to mitochondrial dysfunction, terms related to ATP synthesis and metabolism, aerobic respiration, and acyl co-A metabolism, as well as the synthesis and metabolism of purines and their highly integrated proteins were plotted using a chord plot ( Figure 3 B).…”
Section: Resultssupporting
confidence: 67%
“…In the hippocampal PTE + vs. PTE − comparison, enrichment terms suggested alterations in mitochondrial function and cellular metabolism, as has been reported in blast injury in several recent studies [ 24 , 25 , 26 , 27 ]. To further investigate processes related to mitochondrial dysfunction, terms related to ATP synthesis and metabolism, aerobic respiration, and acyl co-A metabolism, as well as the synthesis and metabolism of purines and their highly integrated proteins were plotted using a chord plot ( Figure 3 B).…”
Section: Resultssupporting
confidence: 67%
“…Although glial cells were originally described by Virchow's and other early studies as purely supportive elements in the brain (Chvatal and Verkhratsky, 2018), years of intensive research revealed their multifaceted function in development and physiological conditions, as well as in various central nervous system (CNS) injuries and diseases, including ischemia (Verkhratsky, 2007;Allen and Lyons, 2018;Mihailova et al, 2023). Here, we briefly introduce the most well known and most studied glial cell types in ischemia -astrocytes, microglia, oligodendrocytes and NG2-glia.…”
Section: Glial Cells and Their Role In Ischemic Injurymentioning
confidence: 98%
“…In addition to neurons, glial cells are also affected and responsive to ischemic injury (Mihailova et al, 2023). Due to their multiple functions and the large number of released cytokines/chemokines, glial cells often have a "dual face" as they can play an irreplaceable role in mitigating/preventing tissue damage, but they also exacerbate inflammation and excitotoxicity (Pekny et al, 2014;Quincozes-Santos et al, 2021).…”
Section: Introductionmentioning
confidence: 99%
“…These findings suggest that disturbances in mitochondrial activity are similar to traumatic brain injuries and AD. Furthermore, mitochondria play a crucial role in various astrocyte processes, emphasizing the importance of balanced mitochondrial dynamics in maintaining brain health [75,76].…”
Section: Mitochondrial Dysfunction In the Vasculature In Cte And Admentioning
confidence: 99%
“…Post-mortem studies have revealed microglial activation using the ligand 3HPK11195, which was present even many years after the traumatic injury. In the analysis of astrocyte activity, which also helps to characterize the range of the brain damage, there may also be fluorescence microscopes [76]. Among the PET ligands used in CTE neuroimaging may also be Fluorodeoxyglucose (FDG), which measures brain metabolism and glucose uptake level.…”
Section: Imagining Of Ctementioning
confidence: 99%