“…EGR1 has been shown to promote differentiation when expressed in embryonal carcinoma cells, which are similar to ESCs, and to regulate differentiation in various contexts (Cao et al, 1990; Carter et al, 2007; Dinkel et al, 1998; Edwards et al, 1991; Harris and Horvitz, 2011; Krishnaraju et al, 1995; Lanoix et al, 1998; Laslo et al, 2006; Le et al, 2005; Lejard et al, 2011; Nguyen et al, 1993; Spaapen et al, 2013; Sukhatme et al, 1988; Topilko et al, 1998; Zhang et al, 2013). Fragola et al proposed that EGR1 functions as a key TF that maintains the fibroblast transcriptional profile (Fragola et al, 2013).…”