The Immune Cells in the Development of Oral Squamous Cell Carcinoma

Caponio, Vito Carlo Alberto; Zhurakivska, Khrystyna; Muzio, Lorenzo Lo; Troiano, Giuseppe; Cirillo, Nicola

doi:10.3390/cancers15153779

Cited by 9 publications

(1 citation statement)

References 135 publications

(175 reference statements)

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“…Overall, the study results suggests that the combination of EGCG and resveratrol, even at low doses where each compound alone has marginal effects on apoptosis, can synergistically enhance apoptosis and inhibit the growth of head and neck tumors. Besides, therapeutic strategy using also depends on the activation of the immune system against tumor 164 - 166 ; intriguingly, a combination of natural polyphenols, containing curcumin (C) with resveratrol (R) and epicatechin gallate (E), termed TriCurin, presenting a unique and synergistic molar ratio, seems to be highly efficient in stimulating the immune system against cancer cells and can be used as a safe immunotherapeutic agent to turn the immune system against HPV+ tumors 167 .…”

Section: Discussionmentioning

confidence: 99%

Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next

Ballini,

Zhurakivska,

Troiano

et al. 2024

J. Cancer

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Head and neck cancers (HNC) are a worldwide health problem, accounting for over 5% of all types of cancers. Their varied nature makes it sometimes difficult to find clear explanations for the molecular mechanisms that underline their onset and development. While chemio- and radiotherapy are clearly not to be dismissed, we cannot undervalue the effect that polyphenols - especially dietary polyphenols - can have in helping us to cope with this medical emergency. By influencing several different proteins involved in numerous different metabolic pathways, polyphenols can have a broad spectrum of biological action and can hopefully act synergistically to tackle down head and neck cancer. Moreover, being natural molecules, polyphenols does not present any side effects and can even enhance drugs efficacy, making our clinical therapy against head and neck cancer more and more effective. Certainly, oxidative stress plays an important role, altering several molecular pathways, lowering the body's defenses, and ultimately helping to create a microenvironment conducive to the appearance and development of the tumor. In this regard, the regular and constant intake of foods rich in polyphenols can help counteract the onset of oxidative stress, improving the health of the general population. In this review, we highlight the role of polyphenols in managing oxidative stress, with such positive effects that they can be considered new tools to use in our anti-head and neck cancer strategy.

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Section: Discussionmentioning

confidence: 99%

Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next

Ballini,

Zhurakivska,

Troiano

et al. 2024

J. Cancer

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The impact of innate immunity and inflammation on the development of oral cancer and their role in tumor promotion and suppression

Karuppan Perumal,

Renuka,

Thangavelu

et al. 2024

Oral Oncology Reports

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Oral squamous cell carcinomas: state of the field and emerging directions

Tan,

Wang,

et al. 2023

Int J Oral Sci

147

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Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and impairs appearance, pronunciation, swallowing, and flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to the Global Cancer Observatory (GCO), the incidence of OSCC will rise by approximately 40% by 2040, accompanied by a growth in mortality. Persistent exposure to various risk factors, including tobacco, alcohol, betel quid (BQ), and human papillomavirus (HPV), will lead to the development of oral potentially malignant disorders (OPMDs), which are oral mucosal lesions with an increased risk of developing into OSCC. Complex and multifactorial, the oncogenesis process involves genetic alteration, epigenetic modification, and a dysregulated tumor microenvironment. Although various therapeutic interventions, such as chemotherapy, radiation, immunotherapy, and nanomedicine, have been proposed to prevent or treat OSCC and OPMDs, understanding the mechanism of malignancies will facilitate the identification of therapeutic and prognostic factors, thereby improving the efficacy of treatment for OSCC patients. This review summarizes the mechanisms involved in OSCC. Moreover, the current therapeutic interventions and prognostic methods for OSCC and OPMDs are discussed to facilitate comprehension and provide several prospective outlooks for the fields.

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The Immune Cells in the Development of Oral Squamous Cell Carcinoma

Cited by 9 publications

References 135 publications

Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next

Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next

The impact of innate immunity and inflammation on the development of oral cancer and their role in tumor promotion and suppression

Oral squamous cell carcinomas: state of the field and emerging directions

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