The Immune Injury Effects and Clinical Significance of Eosinophils in Auto-Immune-Related Hematocytopenia

Abstract

Eosinophils (EOS) quantity, active state, peroxidase activity (POX), and HLA-DR expression in bone marrow of 176 Auto-Immune-Related Hematocytopenia (AIRH) patients were analyzed. Immunofluorescent staining (IF) is performed to observe the expression of immunizing molecules on EOS. In serum of AIRH patients the levels of IL-4, IL-5, IL-6, IL-12, IL-17, and IFN- γ were increased but there was no significance on IL-2 level. In marrow of AIRH, activated EOS expressed POX, and other molecules, it played various cell-mediated immunity injury roles to hemocyte. EOS might be possessed with multiple immunological fuctions, it playes an important immune effect in AIRH autoimmune pathological processes.

Atorvastatin improves bone marrow endothelial progenitor cell function from patients with immune-related hemocytopenia

“…Immune-related hemocytopenia (IRH) is a type of autoimmune disease against bone marrow hematopoietic cells that were discovered in the 1990s, which damages the body's normal hematopoietic function (1,2). Current research posits that immune-related cytopenia is caused by the imbalance of T lymphocyte regulation and the abnormal function of B lymphocytes, thereby producing autoantibodies that destroy or inhibit bone marrow hematopoietic cells, which ultimately leads to a decrease in peripheral blood cells (3).…”