The Immune–Neuroendocrine Network in Health and Disease

Rey, Adriana del; Besedovsky, Hugo O.

doi:10.1002/9781118314814.ch5

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…Inner dialogue is guaranteed by common connecting pathways and by shared receptors and molecules. Over the last 40 years, psychoneuroendocrinoimmunology research has produced incontestable evidence on communications between systems, breaking down the dogma of the lack of communication between the brain and immune system [ 29 , 30 , 31 , 32 , 33 , 34 ]. Figure 1 a,b show the complex and pervasive human biological network, which includes the autonomic nervous system, lymphatic and blood vessels, and the endocrine system.…”

Section: Psyche and Biological Systems: The Bidirectional Pathwaysmentioning

confidence: 99%

Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

Bottaccioli

Bologna

Bottaccioli

2022

IJMS

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Today, it is possible to investigate the biological paths and mechanisms that link mental life to biological life. Emotions, feelings, desires, and cognitions influence biological systems. In recent decades, psychoneuroendocrinoimmunology research has highlighted the routes linking the psyche–brain–immune systems. Recently, epigenetics research has shown the molecular mechanisms by which stress and mental states modulate the information contained in the genome. This research shapes a new paradigm considering the human being as a whole, integrating biology and psychology. This will allow us to progress towards personalized precision medicine, deeply changing medical and psychological sciences and clinical practice. In this paper, we recognize leading research on both bidirectional relations between the psyche–brain–immunity and molecular consequences of psychological and mental states.

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Section: Psyche and Biological Systems: The Bidirectional Pathwaysmentioning

confidence: 99%

Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

Bottaccioli

Bologna

Bottaccioli

2022

IJMS

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“…The immune system is under neuroendocrine control; conversely, products of immune cells can affect central and peripheral nervous activity . Brain‐immune cross‐talk is deeply influenced by mental states and psychosocial factors.…”

Section: Introductionmentioning

confidence: 99%

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

Bottaccioli

Minelli

2018

Annals of the New York Academy of Sciences

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In the last decades, psychoneuroendocrineimmunology research has made relevant contributions to the fields of neuroscience, psychobiology, epigenetics, molecular biology, and clinical research by studying the effect of stress on human health and highlighting the close interrelations between psyche, brain, and bodily systems. It is now well recognized that chronic stress can alter the physiological cross-talk between brain and biological systems, leading to long-lasting maladaptive effects (allostatic overload) on the nervous, immune, endocrine, and metabolic systems, which compromises stress resiliency and health. Stressful conditions in early life have been associated with profound alterations in cortical and subcortical brain regions involved in emotion regulation and the salience network, showing relevant overlap with different psychiatric conditions. This paper provides a summary of the available literature concerning the notable effects of stress on the brain and immune system. We highlight the role of epigenetics as a mechanistic pathway mediating the influences of the social and physical environment on brain structure and connectivity, the immune system, and psycho-physical health in psychiatric diseases. We also summarize the evidence regarding the effects of stress management techniques (mainly psychotherapy and meditation practice) on clinical outcomes, brain neurocircuitry, and immune-inflammatory network in major psychiatric diseases.

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The Immune–Neuroendocrine Network in Health and Disease

Cited by 2 publications

References 44 publications

Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

Psychic Life-Biological Molecule Bidirectional Relationship: Pathways, Mechanisms, and Consequences for Medical and Psychological Sciences—A Narrative Review

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

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