The Immune Response to Vaccination With Inactivated Poliovirus Vaccine in Sweden

Böttiger, M; Arro, Leonida; Lundbeck, H.; Salenstedt, Carl-Rune

doi:10.1111/apm.1966.66.2.239

Cited by 22 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common symp toms are fatigue, increasing muscular weak ness and fasciculations, pain from muscles and joints and respiratory distress [14,15,17], Frequently, these sequelae are not diag nosed at routine examinations performed by an internist [16]. The last epidemic of acute poliomyelitis in Sweden occurred in the mid1950s, and since 1962 only sporadic cases have been encountered among unvaccinated individuals [19], The aim of the present study was to deter mine the prevalence and some clinical charac teristics of the PSS and other neuromuscular diseases. Multiple data sources were used and efforts were made to validate the diagnosis in order to achieve a reliable data base.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Neuromuscular Diseases, Including the Postpolio Sequelae, in a Swedish County

Ahlström

Gunnarsson²,

Leissner

et al. 1993

Neuroepidemiology

View full text Add to dashboard Cite

The epidemiology of neuromuscular diseases was studied in the county of Örebro, Sweden (study population 270,000). Several different sources of data were utilized, compared and validated. On the prevalence day (January 1,1988) 474 patients were identified. The rate per 100,000 population was 92 for the postpolio sequelae (PPS) and 84 for the other neuromuscular diseases (motor neuron disease 9, hereditary neuropathies 9, myoneural disorders 16, myotonic disorders 19, muscular dystrophies 20 and myositis 11). Of the patients with the PPS, 80% reported late-onset symptoms. On the basis of an expanded survey including all medical records in one health care district, the prevalence of the PPS was estimated to be 186/100,000 population.

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiology of Neuromuscular Diseases, Including the Postpolio Sequelae, in a Swedish County

Ahlström

Gunnarsson²,

Leissner

et al. 1993

Neuroepidemiology

View full text Add to dashboard Cite

show abstract

“…The antibody titres against poliovirus type 3, the Saukett strain, were measured first by the tube titration method described previously (3).…”

Section: Methodsmentioning

confidence: 99%

Neutralizing capacity of poliovirus type 3 antibodies tested against 5 different intratypic variants of poliovirus type 3

Böttiger

1971

Archiv f Virusforschung

View full text Add to dashboard Cite

Sera derived from children immunized against poliomyelitis by different procedures showed variations in their ability to neutralize different poliovirus type 3 s~rains. Sera from children immunized with inactivated vaccine neutralized the strain incorporated in the vaccine better than the other strains tested; the sera were 5 times less active against a wild type 3 strain. Groups of sera derived from similar vaeeinees who in addition had obtained a booster of live vaccine did not deviate from this pattern of reaction.Sera of children receiving oral vaccine only (Sabin 3 or Usol-D bae) showed a different pattern of reaction. These sera neutralized both the vaccine strain used and the wild strain tested to approximately the same degTee.

show abstract

“…41 The work of Gard, Lycke, and their colleagues led to the introduction of modified conditions for the production of an inactivated polio vaccine in Sweden. 49,50 The positive experiences of the modified, inactivated vaccine led to the decision in Sweden not to use the live vaccine; the eradication of polio in Sweden was achieved solely with inactivated preparations.…”

Section: Sven Gard and His Rolementioning

confidence: 99%

Polio and nobel prizes: Looking back 50 years

Norrby¹,

Prusiner²

2007

Annals of Neurology

View full text Add to dashboard Cite

In 1954, John Enders, Thomas Weller, and Frederick Robbins were awarded the Nobel Prize in Physiology or Medicine "for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue."5370 This discovery provided for the first time opportunities to produce both inactivated and live polio vaccines. By searching previously sealed Nobel Committee archives, we were able to review the deliberations that led to the award. It appears that Sven Gard, who was Professor of Virus Research at the Karolinska Institute and an adjunct member of the Nobel Committee at the time, played a major role in the events leading to the awarding of the Prize. It appears that Gard persuaded the College of Teachers at the Institute to decide not to follow the recommendation by their Nobel Committee to give the Prize to Vincent du Vigneaud. Another peculiar feature of the 1954 Prize is that Weller and Robbins were included based on only two nominations submitted for the first time that year. In his speech at the Nobel Prize ceremony, Gard mentioned the importance of the discovery for the future production of vaccines, but emphasized the implications of this work for growing many different, medically important viruses. We can only speculate on why later nominations highlighting the contributions of scientists such as Jonas Salk, Hilary Koprowski, and Albert Sabin in the development of poliovirus vaccines have not been recognized by a Nobel Prize.

show abstract

The Immune Response to Vaccination With Inactivated Poliovirus Vaccine in Sweden

Cited by 22 publications

References 12 publications

Epidemiology of Neuromuscular Diseases, Including the Postpolio Sequelae, in a Swedish County

Epidemiology of Neuromuscular Diseases, Including the Postpolio Sequelae, in a Swedish County

Neutralizing capacity of poliovirus type 3 antibodies tested against 5 different intratypic variants of poliovirus type 3

Polio and nobel prizes: Looking back 50 years

Contact Info

Product

Resources

About