The immune system as a system of relations

Daëron, Marc

doi:10.3389/fimmu.2022.984678

Cited by 21 publications

(9 citation statements)

References 99 publications

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“…Moreover, T lymphocytes can mediate cellular immunity after activation by cytokines or chemokines liberated from helper T cells. The interplay between innate and adaptive immunity is well-recognized [ 1 ].…”

Section: Oleic Acid and Immune Cellsmentioning

confidence: 99%

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Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

et al. 2023

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In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70–80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. OA may directly regulate both the synthesis and activities of antioxidant enzymes. The anti-inflammatory effect may be related to the inhibition of proinflammatory cytokines and the activation of anti-inflammatory ones. The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake and energy homeostasis and has therefore been suggested to be a potential therapeutic agent for the treatment of obesity. OEA has anti-inflammatory and antioxidant effects. The beneficial effects of olive oil may be related to the actions of OEA. New evidence suggests that oleic acid may influence epigenetic mechanisms, opening a new avenue in the exploration of therapies based on these mechanisms. OA can exert beneficial anti-inflammatory effects by regulating microRNA expression. In this review, we examine the cellular reactions and intracellular processes triggered by OA in T cells, macrophages, and neutrophils in order to better understand the immune modulation exerted by OA.

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Section: Oleic Acid and Immune Cellsmentioning

confidence: 99%

“…Maintaining an optimal immune system is the best preventive medicine. The major function of the immune system is defense against foreign and/or one’s own malignant cells [ 1 ]. Although the immune system depends on genetic factors, other factors may be modulated by lifestyle.…”

Section: Introductionmentioning

confidence: 99%

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

et al. 2023

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“…The human body’s immune system is a large and complex reaction system that can cope with and recognize many environmental factors and respond to various signals ( Dantzer, 2018 ; Daëron, 2022 ). Different types of cells, antibodies, and cytokines interact synergistically to produce immune responses.…”

Section: Tumor Single-cell Immunoassay Based On Droplet Microfluidicsmentioning

confidence: 99%

Droplets microfluidics platform—A tool for single cell research

Cheng

et al. 2023

Front. Bioeng. Biotechnol.

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Cells are the most basic structural and functional units of living organisms. Studies of cell growth, differentiation, apoptosis, and cell-cell interactions can help scientists understand the mysteries of living systems. However, there is considerable heterogeneity among cells. Great differences between individuals can be found even within the same cell cluster. Cell heterogeneity can only be clearly expressed and distinguished at the level of single cells. The development of droplet microfluidics technology opens up a new chapter for single-cell analysis. Microfluidic chips can produce many nanoscale monodisperse droplets, which can be used as small isolated micro-laboratories for various high-throughput, precise single-cell analyses. Moreover, gel droplets with good biocompatibility can be used in single-cell cultures and coupled with biomolecules for various downstream analyses of cellular metabolites. The droplets are also maneuverable; through physical and chemical forces, droplets can be divided, fused, and sorted to realize single-cell screening and other related studies. This review describes the channel design, droplet generation, and control technology of droplet microfluidics and gives a detailed overview of the application of droplet microfluidics in single-cell culture, single-cell screening, single-cell detection, and other aspects. Moreover, we provide a recent review of the application of droplet microfluidics in tumor single-cell immunoassays, describe in detail the advantages of microfluidics in tumor research, and predict the development of droplet microfluidics at the single-cell level.

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“…It may recognize and exclude antigenic foreign bodies, coordinate with other body systems, and maintain the stability of the body’s internal environment and physiological balance ( 16 , 17 ). The immune system is a special distributed system, that is closely connected with other biological systems, and it is the most effective weapon against pathogen invasion ( 18 , 19 ). The immune system comprises a network of interactions between immune organs, cells, and active substances, including innate immunity, which provides direct host defense, and adaptive immunity, which has precise memory.…”

Section: Introductionmentioning

confidence: 99%

Progress in research on the role of fluoride in immune damage

Zhu,

Wei

2024

Front. Immunol.

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Excessive fluoride intake from residential environments may affect multiple tissues and organs; however, the specific pathogenic mechanisms are unclear. Researchers have recently focused on the damaging effects of fluoride on the immune system. Damage to immune function seriously affects the quality of life of fluoride-exposed populations and increases the incidence of infections and malignant tumors. Probing the mechanism of damage to immune function caused by fluoride helps identify effective drugs and methods to prevent and treat fluorosis and improve people’s living standards in fluorosis-affected areas. Here, the recent literature on the effects of fluoride on the immune system is reviewed, and research on fluoride damage to the immune system is summarized in terms of three perspectives: immune organs, immune cells, and immune-active substances. We reviewed that excessive fluoride can damage immune organs, lead to immune cells dysfunction and interfere with the expression of immune-active substances. This review aimed to provide a potential direction for future fluorosis research from the perspective of fluoride-induced immune function impairment. In order to seek the key regulatory indicators of fluoride on immune homeostasis in the future.

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The immune system as a system of relations

Cited by 21 publications

References 99 publications

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

Droplets microfluidics platform—A tool for single cell research

Progress in research on the role of fluoride in immune damage

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