The Immunobiology of Cancer Immunosurveillance and Immunoediting

Dunn, Gavin P.; Old, Lloyd J.; Schreiber, Robert D.

doi:10.1016/j.immuni.2004.07.017

Cited by 2,556 publications

(1,863 citation statements)

References 105 publications

Supporting

Mentioning

1,750

Contrasting

Unclassified

Order By: Relevance

“…While, in the vast majority of established tumors, tumor-infiltrating lymphocytes are insuffi cient for curtailing tumor growth, resulting in a revised version of the immunosurveillance theory called immunoediting (Dunn et al, 2004;Smyth et al, 2006). In the process of tumorigenesis, cancer cells constantly edit and modulate the host antitumor immune response and the host immune response shapes tumor immunogenicity and clonal selection.…”

Section: Interplays Between Inflammation and Tumorigenesismentioning

confidence: 99%

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

2013

View full text Add to dashboard Cite

Section: Interplays Between Inflammation and Tumorigenesismentioning

confidence: 99%

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

2013

View full text Add to dashboard Cite

“…Recent studies have shown that the postoperative complications were risk factors for the survival or disease recurrence in various types of malignancies 7, 8, 9, 10, 11, 12. Furthermore, some authors have shown that the immunological response against postoperative complications enhanced the viability of undetectable residual tumor cells after surgery, thereby increasing the risk of disease recurrence 13, 14. However, despite numerous studies performed in patients with various types of malignancies, most previous studies have used and evaluated retrospectively collected data with relatively small sample sizes of less than 200 from a single institution.…”

Section: Introductionmentioning

confidence: 99%

Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients’ data from three large phase III randomized trials

et al. 2017

View full text Add to dashboard Cite

This study assessed the impact of postoperative complications on the colorectal cancer survival and recurrence after curative surgery using pooled individual patients’ data from three large phase III randomized trials. In total, 5530 patients were included in this study. The patients were classified as those with postoperative complications (C group) and those without postoperative complications (NC group). The risk factors for the overall survival (OS) and the disease‐free survival (DFS) were analyzed. Postoperative complications were found in 861 (15.6%) of the 5530 patients. The OS and DFS rates at 5 years after surgery were 68.9% and 74.8%, respectively, in the C group and 75.8% and 82.2%, respectively, in the NC group, values that were significantly different between the two groups (P < 0.001). The multivariate analysis demonstrated that postoperative complications were a significant independent risk factor for the OS and DFS. Postoperative complications can worsen the colorectal cancer survival and risk of recurrence. Surgical morbidity must be considered as a stratification factor in future phase III trials evaluating the effects of adjuvant chemotherapy on colorectal cancer.

show abstract

“…[34][35][36] In this context, it is widely known that bacterial carriers, especially Salmonella spp. can induce potent, protective humoral and cellular immune responses against the heterologous antigens 37,38 and can activate the components of the innate immune system.…”

Section: Discussionmentioning

confidence: 99%

Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B

et al. 2007

View full text Add to dashboard Cite

Prostate cancer is the most common malignant tumor in men and is normally associated with increased serum levels of prostatespecific antigen (PSA). Therefore, PSA is one potential target for a prostate cancer vaccine. In this study we analyzed the functionality of new bacterial PSA vaccines, expressed and secreted via the hemolysin (HlyA) secretion system of Escherichia coli, the prototype of Type I secretion systems (T1SS) using an attenuated Salmonella enterica serovar Typhimurium aroA strain as carrier. The data demonstrate that a bacterial live vaccine encompassing T1SS in combination with cholera toxin subunit B can be successfully used for delivery of PSA to induce cytotoxic CD8 þ T-cell responses resulting in an efficient prevention of tumor growth in mice.

show abstract

The Immunobiology of Cancer Immunosurveillance and Immunoediting

Cited by 2,556 publications

References 105 publications

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients’ data from three large phase III randomized trials

Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B

Contact Info

Product

Resources

About