“…Proceeding from published data on LI-induced activation of the endogenous opioid system, it can be suggested that long-term LI depletes the sympathetic stores of opioid peptides inhibiting the release of noradrenaline [2,7,8,10]. Under conditions of partial denervation of the myocardium and hyperactivation of the remaining sympathetic innervation, LI can produce temporary local depletion of endogenous opioids, which aggravates occlusion-induced ischemia and facilitates the development of cardiac arrhythmias.…”