The Immunodiffusion Tests for the Detection of Bovine Leukemia Virus-Infected Animals

Mammerickx, Marc

doi:10.1007/978-1-4613-2341-9_15

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…This antigen preparation contains BLV-gp51 and a small amount of the Mr 24,000 viral core protein. The AGID test is the most widely used method for detection of BLV infection (17), although more sensitive assays have been reported (18). False negatives in recently exposed animals are the main source of incorrect classification (18).…”

Section: Methodsmentioning

confidence: 99%

Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection.

Shanks

Lewin

1989

Proc. Natl. Acad. Sci. U.S.A.

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Genetic potentials (pedigree-estimated breeding value) for milk and for fat were compared in cows grouped according to subclinical stage of bovine leukemia virus infection. Genetic potential for milk production was significantly greater in seropositive cows with persistent lymphocytosis (662 ± 72 kg) and in seropositive hematologically normal cows (554 ± 34 kg) than in seronegative herdmates (418 ± 53 kg). When 305-day twice-daily-milking mature equivalent milk production records for the current lactation were adjusted for genetic potential, bovine leukemia virus-infected cows that were hematologically normal had significantly greater milk production than did seronegative herdmates, suggesting that early bovine leukemia virus infection was positively associated with milk yield. Genetic potential for fat production was significantly greater for cows with persistent lymphocytosis (21 ± 2 kg) than for other seropositive (16 ± 1 kg) and seronegative herdmates (13 ± 2 kg); however, 305-day twice-daily-milking mature equivalent fat production for the current lactation was not significantly different between the groups. Thus, cows with persistent lymphocytosis did not produce fat according to their genetic potential. As an apparent consequence of tendencies for greater milk yield and less fat production, milk fat percentage was significantly reduced in cows with persistent lymphocytosis (3.33 ± 0.09%) and other seropositive cows (3.48 ± 0.05%) relative to seronegative herdmates (3.67 ± 0.07%). These results suggest a need to reevaluate the economic impact of bovine leukemia virus infection on the dairy industry.Bovine leukemia virus (BLV) is a type C retrovirus that causes a chronic B-cell proliferative disease in cattle (1) and is considered an important model for human T-cell leukemia virus type I infection because of many shared molecular and biological features (2, 3). The essential difference between these two oncogenic viruses is that the primary target cell of BLV infection is the B lymphocyte (4).The pathogenesis of BLV infection proceeds in a stepwise fashion. Cattle infected with BLV will produce antibodies to the major BLV envelope glycoprotein (BLV-gpSl) (5), usually followed by the appearance ofantibodies to the viral core protein, p24 (6). Approximately 30% of BLV-infected animals develop a persistent lymphocytosis (PL) (7), which is characterized by a dramatic increase in the percentage and absolute number of B cells in peripheral blood (8, 9). About one-third of the B cells in cattle with PL have BLV provirus (10). The PL stage of BLV infection identifies animals that are at increased risk for developing lymphosarcoma (7), the terminal stage of the disease, and recent studies have shown that susceptibility to B-cell lymphocytosis is under the control of the bovine major histocompatibility complex (11, 12).The economic impact of BLV infection in the United States has been estimated at 44 million dollars per year, primarily because of slaughterhouse condemnation of lymphosarcomatous carcasses (13)...

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Section: Methodsmentioning

confidence: 99%

Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection.

Shanks

Lewin

1989

Proc. Natl. Acad. Sci. U.S.A.

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“…A LEB e a TB são doenças comumente detectadas no animal vivo, com base nos testes da IDGA e da tuberculina (OIE, 2008), sendo que o primeiro demonstra alta especificidade, adequada sensibilidade e grande praticidade, sendo pouco dispendioso (Mammerickx et al, 1987). O teste da tuberculina é aferido como de significativa especificidade para bovinos (Roxo, 1996).…”

Section: Animal Pathology / Scientific Communicationunclassified

Intercorrência entre leucose enzoótica e tuberculose em bovinos abatidos em frigorífico

et al. 2016

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RESUMO: Leucose e tuberculose são doenças que acometem o rebanho bovino e acarretam consideráveis prejuízos econômicos, em virtude do impacto na produtividade, porém há poucos relatos de que elas ocorram concomitantemente. Diante disso, objetivou-se avaliar a intercorrência entre essas doenças em bovinos abatidos no município de São Gotardo, MG, sendo que esses animais foram reagentes à tuberculinização e apresentaram lesões características da doença durante o abate sanitário. Cento e trinta e três amostras de soro sanguíneo, todas oriundas de bovinos positivos para tuberculose, foram analisadas pela técnica de imunodifusão em gel de ágar (IDGA), e a prevalência de bovinos que apresentaram positividade ao teste de IDGA foi de 55,64% (74/133). Os resultados obtidos nesta pesquisa permitiram concluir que a tuberculose e a leucose são doenças presentes nas regiões estudadas e encontram-se disseminadas na população avaliada, com níveis significativos, causando risco à saúde dos animais e das pessoas, dado o caráter zoonótico da tuberculose bovina.

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Production and related variables in bovine leukaemia virus-infected cows

Jacobs

Heeney

Godkin

et al. 1991

Veterinary Research Communications

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The Immunodiffusion Tests for the Detection of Bovine Leukemia Virus-Infected Animals

Cited by 4 publications

References 10 publications

Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection.

Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection.

Intercorrência entre leucose enzoótica e tuberculose em bovinos abatidos em frigorífico

Production and related variables in bovine leukaemia virus-infected cows

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