The Immunogenetics of Photodermatoses

Lee, Chaw-Ning; Chen, Tzu‐Ying; Wong, Tak Wah

doi:10.1007/978-3-030-92616-8_14

Cited by 3 publications

(12 citation statements)

References 65 publications

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“…17 Although the exact mechanism remains unclear, exposure to UVR plays a critical role in the pathogenesis of PMLE and CAD. 18 The failure of normal UVR-induced immunosuppression appears to be the main immunological abnormality in PMLE. This is supported by the persistence of epidermal Langerhans cells following UVB irradiation.…”

Section: Discussionmentioning

confidence: 99%

Demographics and clinical presentations of 844 patients with light and dark skin types with polymorphous light eruption and chronic actinic dermatitis evaluated over 23 years

Maghfour

Mohney

Lim

et al. 2023

Photoderm Photoimm Photomed

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Photodermatoses represent a heterogeneous group of skin disorders that are provoked by ultraviolet radiation (UVR) or visible light exposure. 1 Polymorphous light eruption (PMLE) is the most common photosensitivity disorder, and previously was more commonly reported in women with light skin phototypes aged 20-30 years. 2 Clinically, PMLE is characterized by recurrent, delayed reactions to sunlight, ranging from erythematous papules, papulovesicles, and plaques to erythema multiforme-like lesions on sun-exposed surfaces. The same morphology tends to occur in the same individual. Although the estimated worldwide prevalence ranges from 10% to 20%, with higher rates reported at higher altitudes and in western countries, the occurrence of PMLE in dark-skinned individuals has now been

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Section: Discussionmentioning

confidence: 99%

Demographics and clinical presentations of 844 patients with light and dark skin types with polymorphous light eruption and chronic actinic dermatitis evaluated over 23 years

Maghfour

Mohney

Lim

et al. 2023

Photoderm Photoimm Photomed

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“…Dauguma šių fotodermatozių būdingesnės vaikystėje ar jauniems suaugusiesiems, išskyrus lėtinį aktininį dermatitą, kuris dažniausiai pasireiškia perkopus penktą dešimtmetį. Fotojautrumą patvirtinti padeda atliekami fotoprovokacijos testai, o daugumos fotodermatozių pirmos eilės gydymas -griežta fotoprotekcija [3].…”

Section: Santraukaunclassified

“…Fotodermatozės -tai odos ligos, pasireiškiančios dėl ultravioletinių ir matomųjų saulės spindulių poveikio [2]. Saulės šviesos sukeltos ar provokuotos dermatozės gali būti klasifikuojamos į penkias pagrindines grupes: 1) idiopatines fotodermatozes, 2) antrines fotodermatozes dėl egzogeninių veiksnių, apimant fototoksines ir fotoalergines reakcijas, 3) fotodermatozes dėl endogeninių veiksnių, pavyzdžiui, sergant metaboline liga porfirija 4) dėl saulės spindulių paūmėjusias dermatozes, kaip atopinis dermatitas, rožinė ir 5) genodermatozes [3]. Siekiant nustatyti fotodermatozės priežastį ir teisingą diagnozę, labai svarbu surinkti išsamią paciento anamnezę, įvertinti bėrimo pobūdį ir morfologiją bei paskirti būtinus tyrimus tiksliai diferencinei diagnostikai [4].…”

Section: įVadasunclassified

Idiopatinės Fotodermatozės. Klinikiniai Požymiai, Diagnostika Ir Gydymo Galimybės

Ponelytė¹,

Ramonaite²

2023

Health Sciences

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Idiopatinės fotodermatozės sudaro didžiausią padidėjusio jautrumo saulės ar dirbtinei šviesai ligų grupę ir jų patogenezė daugiausia remiasi imunologiniais mechanizmais [1]. Idiopatinėms fotodermatozėms priklauso polimorfinė šviesos dermatozė (PŠD), aktininis niežulys (AN), Hydroa vacciniforme (HV), lėtinis aktininis dermatitas (LAD) bei saulės dilgėlinė (SD) [2]. Dauguma šių fotodermatozių būdingesnės vaikystėje ar jauniems suaugusiesiems, išskyrus lėtinį aktininį dermatitą, kuris dažniausiai pasireiškia perkopus penktą dešimtmetį. Fotojautrumą patvirtinti padeda atliekami fotoprovokacijos testai, o daugumos fotodermatozių pirmos eilės gydymas – griežta fotoprotekcija [3].

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“…10 These sex and age patterns appear to be more pronounced in Asian populations. 3,14 CAD follows a relapsing and remitting course, which significantly compromises the affected individual's quality of life. 6 The diagnosis of CAD is based on clinical presentation, phototesting, and histological examination.…”

Section: Introductionmentioning

confidence: 99%

“… 10 These sex and age patterns appear to be more pronounced in Asian populations. 3 , 14 CAD follows a relapsing and remitting course, which significantly compromises the affected individual’s quality of life. 6 …”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Chronic Actinic Dermatitis with Tofacitinib

Zhong,

Ali,

Yang

et al. 2024

CCID

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We present the case of a 58-year-old male patient who presented with pruritic skin plaques and papules on the scalp, face, back, and back of the hands for over a year. The symptoms worsened upon exposure to sunlight and improved on cloudy days. Despite previous attempts at treatment with glucocorticoid ointment and antihistamine drugs, the patient experienced progressive aggravation of symptoms. Physical examination revealed hypertrophic and infiltrating nodules, with significant scratches and local exudation. Skin biopsy confirmed the diagnosis of sun-induced dermatosis. The patient was initiated on tofacitinib, an oral Janus Kinase inhibitor, along with a halometasone ointment, oral ebastine tablets, and strict sun protection. Over the course of four revisits spanning four months, the patient experienced a significant improvement in symptoms, with the rash almost disappearing and pruritus subsiding. The treatment was well tolerated and no adverse effects were observed. Follow-up for six months post-treatment showed no recurrence of symptoms. This case highlights the efficacy of tofacitinib in managing sun-induced pruritic plaques and suggests it as a potential therapeutic option in similar cases.

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The Immunogenetics of Photodermatoses

Cited by 3 publications

References 65 publications

Demographics and clinical presentations of 844 patients with light and dark skin types with polymorphous light eruption and chronic actinic dermatitis evaluated over 23 years

Demographics and clinical presentations of 844 patients with light and dark skin types with polymorphous light eruption and chronic actinic dermatitis evaluated over 23 years

Idiopatinės Fotodermatozės. Klinikiniai Požymiai, Diagnostika Ir Gydymo Galimybės

Successful Treatment of Chronic Actinic Dermatitis with Tofacitinib

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