The immunologic therapy of squamous cell carcinoma

Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma

“…Although van Kampen et al (1973) tracts successfully, but again gave no details of any adjustment or calculation of protein content of preparations.…”

“…Successful immunotherapy trials have been reported in haemopoietic disease of humans and rodents (Mathe, 1971;Parr 1972), in bovine squamous-cell carcinoma (van Kampen et al, 1973;Spradbrow et al, 1977), and in some solid tumours of humans (Hughes et al, 1970). The need for careful evaluation of immunotherapeutic treatment has been shown by Spradbrow et al (1977) who obtained regression of bovine squamous-cell carcinoma with single treatments, but enhancement with multiple treatments.…”

Veterinary oncology: A survey

“…Particularly interesting is the demonstration that this tumour can be successfully treated by immunotherapy. 62 In Australia, Spradbrow et al 63 have used a single intramuscular injection of the aqueous phase of saline-phenol extracts of a 'cancer eye' lesion to treat a number of animals successfully. The authors note that spontaneous regression of precursor lesions is common, and one s uamous-Squamous-cell carcinoma of the unpigmented vulva1 skin of Ayrshire cattle was reported in Kenya by B~r d i n ,~~ and a similar lesion has been noted in local cattle in Ceylon, where Wettimuny5' has described the progession of the tumours through a papillomatous to a carcinomatous stage, with occasional cutaneous horn development.…”

Epithelial cells cultured from bovine ocular carcinoma

“…Immunologic maneuvers have been used in the treatment of cattle suffering from this cancer. (Van Kampen et al, 1973;Kleinschuster et al, 1977: Rapp et al, 1976Spradbrow et al, 1977). New approaches to studies of the mechanism of these maneuvers would be possible if continuous cultures of epithelial cancer cells derived from the bovine neoplasm were available.…”