DOI: 10.1159/000385896
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The Immunological Activities of Lymphocytes

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Cited by 120 publications
(109 citation statements)
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“…For the two anti-RS sera presented this difference is fourfold. At first sight it seems surprising that an inoculum known to proliferate in FI hosts (10)(11)(12)(13)(14) should yield a less active antiserum than a dead inoculum. Two observations might help to explain this.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…For the two anti-RS sera presented this difference is fourfold. At first sight it seems surprising that an inoculum known to proliferate in FI hosts (10)(11)(12)(13)(14) should yield a less active antiserum than a dead inoculum. Two observations might help to explain this.…”
Section: Discussionmentioning
confidence: 99%
“…Although the subject of current investigations, observations made so far have revealed that the injection of l0 G, 6 X 106, and even 200 X 106 parental strain lymphoid cells into F~ hosts all resulted in similar anti-RS titers. Even though there is little doubt that donor cells will multiply in F1 animals in response to foreign transplantation antigens (10)(11)(12)(13)(14), this process appears to plateau-off quite soon. It seems that irrespective of the dose of donor cells used, mutual neutralization takes place, the only difference being the level at which this process works.…”
Section: Discussionmentioning
confidence: 99%
“…Such functions as the memory cell (ll) or the precursor cell in the immune response have generally been ascribed to the lymphocyte. However, in considering the fully responding cell of the immune response, it has been suggested in several schemes that the lymphocyte is the effector cell in delayed hypersensitivity, graft rejection, and the graft-versus-host phenomenon, but that the plasma cell is the producer of immunoglobulin and antibody (12)(13)(14). The electron microscope has now demonstrated ceils clearly of the 1sm-phocytic category as the sole cells in the centers of hemolytic plaques, and therefore the cells which have obviously synthesized and secreted humoral antibody, in several situations: in a few cells of the lymph node (2) and lymph (3), in 13% of several hundred PFC of the lymph nodes and spleens (1), and now as almost the entire population in the efferent lymph of a lymph node engaged in a vigorous immune response.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, in lymph nodes, the localization of the large blast cells is predominantly in the cortex, while immature and mature plasma cells proliferate in the medullary cords. In view of the recent demonstration (35,36) that small lymphocytes can become transformed into the immunologically competent large blast cells, the close relationship of these plasma cell precursors with lymphoid tissue is not surprising. It appears likely that during the primary response such a transformation of small lymphocytes to hemocytoblasts occurs (37), but the role of the small lymphocyte in the secondary response is less clearly established.…”
Section: Discussionmentioning
confidence: 99%