The immunological consequences of photodynamic treatment of cancer, a literature review

Duijnhoven, Frederieke van; Aalbers, Remco I.J.M.; Rovers, Jeroen; Terpstra, Onno T.; Kuppen, Peter J. K.

doi:10.1078/0171-2985-00221

Cited by 135 publications

(86 citation statements)

References 55 publications

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“…The antigen presenting cells will process the tumor antigens and will present them on the surface of the membrane together with the major histocompatibility complex class II. This is followed by the activation of LT helper and consecutively cytoxic LT. CD4 and CD8 clone T cells are formed, they are capable of recognizing the tumor cells, they expand rapidly and get activated and generate a strong immune response (Van Duijnhoven et al, 2003). In addition the LB and NK cells are activated contributing to the immune response after PDT.…”

Section: Pdt and Immunitymentioning

confidence: 99%

“…Nevertheless TNF-, Il-1 , Il-2, IL-6, Il-8 and Il-10 may represent criteria of evaluation for response to PDT (Yom et al, 2003). PDT amplifies the host immune response; this may explain the regression of untreated tumor metastasis after PDT applied on the primary tumor (Van Duijnhoven et al, 2003). Because lymphocytes act not only on tumor cells from the primary site but also on the metastasis, PDT may be considered a systemic therapy.…”

Section: Pdt and Immunitymentioning

confidence: 99%

See 1 more Smart Citation

Photodynamic Therapy in Skin Cancer

Clichici¹,

Filip²

2011

Skin Cancers - Risk Factors, Prevention and Therapy

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Section: Pdt and Immunitymentioning

confidence: 99%

Section: Pdt and Immunitymentioning

confidence: 99%

Photodynamic Therapy in Skin Cancer

Clichici¹,

Filip²

2011

Skin Cancers - Risk Factors, Prevention and Therapy

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“…1 van Duijnhoven et al 1 addressed the effect of PDT on the immune response in patients with solid tumors. They suggested that through destroying the structure of a tumor, PDT enables direct interaction between immune cells and tumor cells; this type of "in situ vaccination" induces a systemic antitumor immune response.…”

Section: The Immunobiology Of Photodynamic Therapy: the Potential Formentioning

confidence: 99%

The Immunobiology of Photodynamic Therapy: The Potential for Therapeutic Intervention in Lung Cancer

Moffatt-Bruce¹

2012

J Natl Compr Canc Netw

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Studies have shown that photodynamic therapy (PDT) causes or enhances an antitumor immune response. Moving from a mouse model in lung cancer to a translational approach, researchers are conducting an ongoing observational study to determine whether the immune response in patients with lung cancer treated with PDT is mediated by a T-cell phenotype, which may result in decreased tumor size and potentially improve survival. Preliminary findings focus on certain inflammatory cytokines that may be predictive of these T-cell phenotypes, such as interleukin ( Bruce shared the very early findings of her current study to determine whether the immune response in patients with non-small cell lung cancer (NSCLC) treated with PDT is T-cell mediated. She briefly explored the ongoing journey to clarify the immunologic response of PDT in patients with lung cancer in the hope of optimizing the ability to predict patient outcomes and translating the defined immune profile of PDT treatment in lung cancer into effective therapeutic interventions.One review served as a background for the rationale behind exploring the immunologic consequences of PDT in cancer treatment.1 van Duijnhoven et al. 1 addressed the effect of PDT on the immune response in patients with solid tumors. They suggested that through destroying the structure of a tumor, PDT enables direct interaction between immune cells and tumor cells; this type of "in situ vaccination" induces a systemic antitumor immune response. Another retrospective review (coauthored by Dr. Moffatt-Bruce's colleague and mentor Dr. Patrick Ross) 2 focused on the incorporation of PDT into the induction therapy regimen for locally advanced primary nonmetastatic NSCLC bronchogenic carcinoma. Fifty percent of patients initially deemed unresectable were able to undergo definitive surgical resection after trimodality induction therapy consisting of PDT with chemotherapy and/ or irradiation.2 In addition, 27% of patients considered to require pneumonectomy were able to have a lobectomy after trimodality induction therapy.2 Finally, the pathologic stage was less than the preinduction clinical stage in 14 of 22 cases, of which 4 patients had no residual tumor.2

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“…The wavelength of treatment light is chosen based on the absorption spectrum of the PS as well as the necessary penetration depth of the light. The destruction of cancer tissue by PDT can be due to direct killing of tumor cells through generation of reactive oxygen species (ROS) [9], or indirectly by reducing the blood supply through vascular damage [10] or post-PDT activation of an antitumor immune response [11]. The anti-vascular effects of PDT are particularly important in determining the progression of the photoreaction and treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Blood flow dynamics during local photoreaction in a head and neck tumor model

et al. 2015

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We have applied continuous blood flow dynamics, quantified with diffuse correlation spectroscopy (DCS), in investigating photodynamic therapy (PDT) induced local photoreaction in a head and neck tumor model. Photoclor (0.47 µmol/kg) was intravenously administered 24 h before PDT. Two types of fluence rates were implemented: Low fluence rate (14 mW/cm 2 ) and high fluence rate (75 mW/cm 2 ). The total delivered fluence was 100 J/cm 2 for both types. We observed that PDT induced substantial vascular shut down in both types. While the shutdown was persistent in tumors exposed to low fluence rate PDT, the shutdown was transient in tumors exposed to high fluence PDT. Loss of microvascular structures was confirmed by the microscopic analyses of tumor section following immunostaining for CD31. Blood flow dynamics related metrics were also strongly correlated with crosslinking of STAT3, a molecular marker of photoreaction. STAT3 analysis indicated that low fluence rate yields a substantially higher photoreaction, and thus, a more effective PDT. Our results indicate that non-invasive blood flow measurements can monitor the efficacy of PDT in real-time and potentially provide a feedback for its optimization.

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The immunological consequences of photodynamic treatment of cancer, a literature review

Cited by 135 publications

References 55 publications

Photodynamic Therapy in Skin Cancer

Photodynamic Therapy in Skin Cancer

The Immunobiology of Photodynamic Therapy: The Potential for Therapeutic Intervention in Lung Cancer

Blood flow dynamics during local photoreaction in a head and neck tumor model

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