The immunological era in melanoma treatment: new challenges for heat shock protein-based vaccine in the advanced disease

Pietro, Alessandra di; Tosti, Giulio; Ferrucci, Pier Francesco; Testori, Alessandro

doi:10.1517/14712598.2011.605353

Cited by 8 publications

(6 citation statements)

References 86 publications

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“…In fact, autologous tumor‐derived HSPs (e.g. HSP96‐peptide complex [HSPPC‐96], HSPPC‐70, etc) have been evaluated as tumor vaccines in a variety of phase I‐III trials over a wide range of cancers, with clinical benefit in some melanoma patients …”

Section: Alarmins and Tumor Immunitymentioning

confidence: 99%

Alarmins and immunity

Yang

Han

Oppenheim

2017

Immunological Reviews

320

241

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SUMMARY More than a decade has passed since the conceptualization of the ‘alarmin’ hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participarnts in a diverse range of physiological and pathophysiological processes such as host defense, regulation of gene expression, cellular homeostasis, wound healing, inflammation, allergy, autoimmunity, and oncogenesis. Here we provide a general view on the participation of alarmins in the induction of innate and adaptive immune responses, as well as their contribution to tumor immunity.

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Section: Alarmins and Tumor Immunitymentioning

confidence: 99%

Alarmins and immunity

Yang

Han

Oppenheim

2017

Immunological Reviews

320

241

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“…GRP94 plays an important role in immune responses by facilitating MHC class I molecule mediated antigen presentation, and by inducing the maturation and activation of various cells involved in innate and adapted immune responses, including macrophages, DCs, T cells and B cells 109–111 . Therefore, it might be expected that GRP94 could elicit an antitumor response.…”

Section: The Role Of Grp94 and Other Chaperones In Antitumor Vaccinationmentioning

confidence: 99%

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

2012

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Cancer progression is characterized by rapidly proliferating cancer cells that are in need of increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is required to facilitate the folding, assembly and transportation of membrane and secretory proteins. These functions are carried out by ER chaperones. It is now becoming clear that the ER chaperones have critical functions outside of simply facilitating protein folding. For example, cancer progression requires GRP78 for cancer cell survival and proliferation, as well as angiogenesis in the microenvironment. GRP78 can translocate to the cell surface acting as a receptor regulating oncogenic signaling and cell viability. Calreticulin, another ER chaperone, can translocate to the cell surface of apoptotic cancer cells and induce immunogenic cancer cell death and antitumor responses in vivo. Tumor-secreted GRP94 has been shown to elicit antitumor immune responses when used as antitumor vaccines. Protein disulfide isomerase is another ER chaperone that demonstrates pro-oncogenic and pro-survival functions. Due to intrinsic alterations of cellular metabolism and extrinsic factors in the tumor microenvironment, cancer cells are under ER stress, and they respond to this stress by activating the unfolded protein response (UPR). Depending on the severity and duration of ER stress, the signaling branches of the UPR can activate adaptive and pro-survival signals, or induce apoptotic cell death. The PERK signaling branch of the UPR has a dual role in cancer proliferation and survival, and is also required for ER stress-induced autophagy. The activation of the IRE1α branch promotes tumorigenesis, cancer cell survival, and regulates tumor invasion. In summary, perturbance of ER homeostasis plays critical roles in tumorigenesis, and therapeutic modulation of ER chaperones and/or UPR components presents potential antitumor treatments.

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“…However, no studies have been reported on the potential of 14-3-3γ as a marker for the prognosis of patients with NPC. Clinically, a proteomics study to identify hepatocellular carcinoma (HCC)-related biomarkers found that 14-3-3γ is up-regulated in HCC [36]. Recently, it is reported that 14-3-3γ is a predictor of a high risk of extrahepatic metastases and worse survival in human hepatocellular carcinoma [37].…”

Section: Discussionmentioning

confidence: 99%

Quantitative proteome analysis of overexpressed Cripto-1 tumor cell reveals 14-3-3γ as a novel biomarker in nasopharyngeal carcinoma

Weng

2013

Journal of Proteomics

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The immunological era in melanoma treatment: new challenges for heat shock protein-based vaccine in the advanced disease

Cited by 8 publications

References 86 publications

Alarmins and immunity

Alarmins and immunity

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

Quantitative proteome analysis of overexpressed Cripto-1 tumor cell reveals 14-3-3γ as a novel biomarker in nasopharyngeal carcinoma

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