The immunomodulation role of Th17 and Treg in renal transplantation

Huang, Daixin; He, Yi-Ran; Liu, Yujing; He, Hong; Gu, Zhifeng; Liu, Yimei; Liu, Wenjun; Luo, Zhe; Ju, Minghe

doi:10.3389/fimmu.2023.1113560

Cited by 14 publications

(7 citation statements)

References 85 publications

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“…Th17 cells are a subgroup of CD4 + T cells that mediate inflammatory responses and play an important role in acute and chronic allograft rejection reactions. [27][28][29] The inability of the mother to establish pregnancy may be caused by immune rejection of the fetus by semi-allogeneic antigens, where Th17 cells play an important role. Recent studies have shown that the percentage of Th17 cells increases in patients with unexplained RSA, which may be related to its pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Regulatory T Cell and T Helper 17 Cell Imbalance in Patients with Unexplained Infertility

Lu,

Zhang

2024

IJWH

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Purpose Female infertility is a global health concern. The aim of this study was to investigate the relationship between regulatory T (Treg) cells and helper T cells 17 (Th17) in peripheral blood and unexplained infertility (UI). In addition, we explored potential valuable diagnostic biomarkers for patients with UI and ascertained whether Treg and Th17 cells are associated with primary and secondary UI. Patients and Methods The patients underwent standard fertility evaluation test, including blood tests, ultrasound examination, fallopian tube tests, ovulation assessment, and male partner’s semen analysis. According to the inclusion and exclusion criteria, this study enrolled 37 patients with UI (30 with primary UI and 7 with secondary UI) and 26 age-matched healthy volunteers as the control group. Flow cytometry was used to detect the frequency of Treg and Th17 cells. The area under the receiver operating characteristic curve (AUC) with a 95% confidence interval (CI) was used to assess the diagnostic performance. An AUC > 0.800 indicated good diagnostic performance. Results The percentage of Treg decreased significantly, whereas the percentage and absolute count of Th17 cells increased. Moreover, the Th17/Treg ratio in patients with UI increased significantly. As a diagnostic biomarker for UI, the Th17/Treg ratio exhibited remarkable diagnostic performance (AUC: 0.813 (95% CI = 0.709–0.917)). However, the percentages and absolute counts of Treg and Th17 cells in the peripheral blood of women with primary and secondary UI, as well as their Th17/Treg ratios, did not differ significantly. Conclusion The distribution of Treg and Th17 cells is imbalanced in patients with UI. Therefore, the Th17/Treg ratio may be a promising indicator of UI. However, there were no significant differences in the distribution of Treg and Th17 cells between women with primary and secondary UI.

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Section: Discussionmentioning

confidence: 99%

Regulatory T Cell and T Helper 17 Cell Imbalance in Patients with Unexplained Infertility

Lu,

Zhang

2024

IJWH

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“…Treg cells inhibit activated T cells and regulate immunity [ 21 , 22 ]. CD4 + CD25 + and FOXP3 + Treg cell expression negatively correlates with acute rejection [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Induction Immunosuppressants on T Lymphocyte Subsets after Kidney Transplantation: A Prospective Observational Study with Focus on Anti-Thymocyte Globulin and Basiliximab Induction Therapies

Kim,

Bae,

Yun

et al. 2023

IJMS

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Induction immunosuppressive therapy for kidney transplant recipients (KTRs) primarily includes interleukin-2 receptor antagonists, such as basiliximab (BXM) or lymphocyte-depleting agents, and anti-thymocyte globulin (ATG). This study aimed to investigate their effects on T cell dynamics during the early post-transplantation period. This prospective observational study included 157 KTRs. Peripheral blood samples were collected from each patient within 5 days before and 4 and 12 weeks after transplantation. Flow cytometric analysis was performed to assess various T cell subsets whose changes were then analyzed. In the ATG group, CD4+ T cell expression decreased significantly compared with that in the BXM group. However, CD4+CD161+ and CD4+CD25+CD127low T cell expression levels increased significantly. In the CD8+ T cell subset, a decrease in CD8+CD28nullCD57+ and CD8+CCR7+ T cell expression was observed in the ATG group. However, among patients diagnosed with biopsy-proven acute rejection, T cell subset expression did not significantly differ relative to non-rejection cases. In conclusion, ATG induction therapy resulted in more pronounced changes in T lymphocyte subsets than BXM induction, with increased CD4+CD161+ and CD4+CD25+CD127low T cells and an early decrease in CD8+CD28nullCD57+ and CD8+CCR7+ T cells, some of which are associated with acute rejection.

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“…IL-6 binds to IL-6R, which can then trigger downstream signal transduction and gene expression. The combination of IL-6 and TGF- β induces the retinoid-related orphan receptor (ROR) γ t, which are the key transcription factors in determining the differentiation of the Th17 lineage [ 34 ]. In this study, we showed that carnosol inhibits Th17 differentiation mainly via IL-6-IL-6R signaling.…”

Section: Discussionmentioning

confidence: 99%

Carnosol Alleviates Collagen‐Induced Arthritis by Inhibiting Th17‐Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells

Sun

et al. 2023

BioMed Research International

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Current approaches are incurable for rheumatoid arthritis (RA). Regulatory T (Treg) cells and T helper cells (Th1 and Th17) are crucial in controlling the process of RA, which is characterized by inflammatory cell infiltration and bone destruction. Carnosol is an orthodiphenolic diterpene that has been extensively applied in traditional medicine for the treatment of multiple autoimmune and inflammatory diseases. Herein, we indicate that administration of carnosol dramatically alleviated the severity of collagen-induced arthritis (CIA) model with a decreased clinical score and inflammation reduction. Cellular mechanistically, carnosol inhibits the Th17 cell differentiation and maintains Treg cell suppressive function in vitro and in vivo. Meanwhile, it also restrains Treg cells from transdifferentiation into Th17 cells under inflammatory milieu. Furthermore, carnosol modulates the function of Th17 and Treg cells possibly via limiting IL-6R (CD126) expression. Collectively, our results suggest that carnosol can alleviate the severity of CIA via hiding Th17 cell differentiation and maintain the stability of Treg cells. Administration of carnosol can be applied as a potential therapy for patients with RA.

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The immunomodulation role of Th17 and Treg in renal transplantation

Cited by 14 publications

References 85 publications

Regulatory T Cell and T Helper 17 Cell Imbalance in Patients with Unexplained Infertility

Regulatory T Cell and T Helper 17 Cell Imbalance in Patients with Unexplained Infertility

Impact of Induction Immunosuppressants on T Lymphocyte Subsets after Kidney Transplantation: A Prospective Observational Study with Focus on Anti-Thymocyte Globulin and Basiliximab Induction Therapies

Carnosol Alleviates Collagen‐Induced Arthritis by Inhibiting Th17‐Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells

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