The immunopathogenesis of birdshot chorioretinopathy; a bird of many feathers

Kuiper, Jonas J.W.; Rothová, Aniki; Boer, Joke de; Radstake, Timothy R D J

doi:10.1016/j.preteyeres.2014.11.003

Cited by 60 publications

(67 citation statements)

References 169 publications

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“…The correlation between BSCR and the classical allele HLA-A*2902 represents one of the strongest associations between the HLA region and disease reported to date 33. In this regard, our results suggest that this effect could be driven by the amino acid Leu-62/Gln-63.…”

Section: Discussionsupporting

confidence: 51%

“…Specifically, the top associated signal belonged to the classical allele HLA-A*2902 (p=1.04E-16, OR=2.41). The strong association between this HLA allele and BSCR is well established,33 and many patients with this condition (n=78/579) were included in our analysis. Therefore, in order to determine whether this signal was due to a strong association with the BSCR subgroup of patients, we decided to further stratify our analyses of the HLA region by considering the patients with BSCR on one hand and the remaining patients with uveitis on the other hand.…”

Section: Resultsmentioning

confidence: 99%

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New insights into the genetic component of non-infectious uveitis through an Immunochip strategy

et al. 2016

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Background Large-scale genetic studies have reported several loci associated with specific disorders involving uveitis. Our aim was to identify genetic risk factors that might predispose to uveitis per se, independent of the clinical diagnosis, by performing a dense genotyping of immune-related loci. Methods 613 cases and 3693 unaffected controls from three European case/control sets were genotyped using the Immunochip array. Only patients with noninfectious non-anterior uveitis and without systemic features were selected. To perform a more comprehensive analysis of the human leucocyte antigen (HLA) region, SNPs, classical alleles and polymorphic amino acid variants were obtained via imputation. A meta-analysis combining the three case/control sets was conducted by the inverse variance method. Results The highest peak belonged to the HLA region.

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Section: Discussionsupporting

confidence: 51%

Section: Resultsmentioning

confidence: 99%

New insights into the genetic component of non-infectious uveitis through an Immunochip strategy

et al. 2016

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“…We also found a trend toward an association between CT changes and MD at baseline, as also suggested by previous studies [14], but this may simply reflect disease duration. Visual field defects may reflect the inflammatory process within the choroid and/or the retina [7].…”

Section: Discussionmentioning

confidence: 99%

“…These choroidal lesions may correspond to choroidal lymphocytic aggregations on histopathology [3,7]. ICGA is considered a reliable method to monitor treatment effectiveness [8].…”

Section: Introductionmentioning

confidence: 99%

Choroidal Thickness in Birdshot Retinochoroiditis Over a 2-Year Period

et al. 2018

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Purpose: To evaluate 2-year choroidal changes in eyes with birdshot retinochoroiditis (BRC). Methods: Thirteen patients (26 eyes) with BRC were prospectively evaluated during a 2-year period with standard automated perimetry (SAP), fluorescein angiography, indocyanine green angiography and optical coherence tomography (Spectralis Heidelberg Retinal Angiograph + optical coherence tomography). Enhanced-depth imaging optical coherence tomography was performed. Results: Eight patients (61%) were females; the patients mean age was 60 ± 4.7 (range 49–66) years. At baseline, best-corrected visual acuity (BCVA) was 0.08 ± 0.2 and foveal sensitivity threshold (FST) at SAP was 34.04 ± 2.6; at 2-year visit, no significant changes were observed (BCVA 0.06 ± 02, p = 0.1 and FST 34.36 ± 2.6, p = 0.1). In all cases, at the 2-year visit, a significant reduction of choroidal thickness was present only at the fovea (p = 0.01). The rate of foveal choroidal thinning was 1.8 ± 1.6 µm per month. When compared to baseline, suprachoroidal fluid (SCF) was more frequent (42.3 vs. 23%; p = 0.002). The amount of foveal choroidal thinning was associated with the presence of SCF at baseline (p = 0.005). Conclusion: In patients with BRC, foveal choroidal thinning and increase of SCF at 2-year follow-up can be observed, even in the absence of visual loss.

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“…ERAP2 affects antigen processing for HLA class I, and this finding provides a novel mechanism explaining the genetic predisposition for this disease. 82 …”

Section: Hla Genesmentioning

confidence: 99%