The immunophenotypes of blast cells in B-cell precursor acute lymphoblastic leukemia: How different are they from their normal counterparts?

Sędek, Łukasz; Bulsa, Joanna; Sonsala, Alicja; Twardoch, Magdalena; Wieczorek, Maria; Malinowska, Iwona; Derwich, Katarzyna; Niedźwiecki, Maciej; Sobol‐Milejska, Grażyna; Kowalczyk, Jerzy; Mazur, Bogdan; Szczepański, Tomasz

doi:10.1002/cyto.b.21176

Cited by 38 publications

(37 citation statements)

References 33 publications

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“…The reader is referred to the vast literature on these flow cytometric approaches to MRD evaluation. The main difficulty in B-lineage ALL is the occurrence of normal B-lymphoid precursor cells, hematogones, 21,22 which can be easily misinterpreted as MRD. Changes in antigen profiles with treatment are found in both diseases though they rarely interfere with MRD detection in ALL.…”

Section: Discussionmentioning

confidence: 99%

Minimal Residual Disease in AML: Why Has It Lagged Behind Pediatric ALL?

Paietta

2015

Clinical Lymphoma Myeloma and Leukemia

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Although the concept of minimal residual disease (MRD) as an indicator for the quality of treatment response is the same in acute myeloid (AML) and acute lymphoid leukemia (ALL), the practice of measuring MRD levels for monitoring response and guiding post-induction therapy has been implemented much more rapidly in ALL, particularly pediatric ALL, than in AML. This perspective will look at the facts and discuss why ALL appears to be more amenable to MRD-shaped risk-allocation and a revised definition of complete remission.

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Section: Discussionmentioning

confidence: 99%

Minimal Residual Disease in AML: Why Has It Lagged Behind Pediatric ALL?

Paietta

2015

Clinical Lymphoma Myeloma and Leukemia

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“…Существуют значительные различия в иммунофе-нотипе опухолевых бластов при ВП-ОЛЛ и нормаль-ных В-линейных предшественников (ВП) [28][29][30][31]. Именно на этих особенностях ассоциированного с лейкозом иммунофенотипа и строится поиск остаточ-ных лейкемических клеток.…”

Section: анализ и интерпретация данныхunclassified

Standardization of Flow Cytometric Minimal Residual Disease Monitoring in Children With B-Cell Precursor Acute Lymphoblastic Leukemia. Russia–belarus Multicenter Group Experience

Popov¹,

Belevtsev²,

Боякова³

et al. 2016

Onkogematologiâ

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“…3 [7][8][9][10][11][12][13][14][15][19][20][21]. Следует отметить, что зачастую на графиках отсутствует четкая граница между нормальными и опухолевыми бластными элементами.…”

Section: нормальное развитие в-лимфоцитовunclassified

Acute Leukemias: Immunophenotypic Differences between Blast Cells and Their Nonneoplastic Analogues in Bone Marrow

Popov

Verzhbitskaya

et al. 2016

Клиническая онкогематология

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Flow cytometry immunophenotyping of bone marrow tumor blasts is one of the principal methods used for acute leukemia (AL) diagnosing. Normal lymphopoietic and myelopoietic progenitors have very similar antigenic profile with leukemic cells, thus, making the AL diagnosing more difficult. Genetic disorders resulting in formation of a tumor clone contribute to development of an immunophenotype that differs from normal cells. Aberrant expression of markers detected in AL blast cells alone forms a so-called leukemia-associated immunophenotype. The leukemia-associated immunophenotype detection by multicolor flow cytometry permits distinguishing between normal and neoplastic cells. This requires simultaneous assessment of many markers on the same cells, which is possible only if multicolor flow cytometry with well-designed and well-established antibodies panels is used. Moreover, correct interpretation of the cell population location on dot plot requires adequate cytometer setup, standardized sample preparation and enough experienced personnel. That is why correct immunophenotyping is often possible only in large laboratories performing reference immunophenotyping within the frames of multicenter trials.

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The immunophenotypes of blast cells in B-cell precursor acute lymphoblastic leukemia: How different are they from their normal counterparts?

Cited by 38 publications

References 33 publications

Minimal Residual Disease in AML: Why Has It Lagged Behind Pediatric ALL?

Minimal Residual Disease in AML: Why Has It Lagged Behind Pediatric ALL?

Standardization of Flow Cytometric Minimal Residual Disease Monitoring in Children With B-Cell Precursor Acute Lymphoblastic Leukemia. Russia–belarus Multicenter Group Experience

Acute Leukemias: Immunophenotypic Differences between Blast Cells and Their Nonneoplastic Analogues in Bone Marrow

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