The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI‐1 and bcl‐2 is similar to ameloblastoma but different from odontogenic cysts

Vered, Marilena; Peleg, Oren; Taicher, Shlomo; Buchner, Amos

doi:10.1111/j.1600-0714.2009.00778.x

Cited by 61 publications

(43 citation statements)

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“…Second, recent laboratory research has suggested that a knowledge of the molecular and genetic alterations associated with KCOTs may predict individual biological behavior [10]. Vered et al [5] suggest that the immuneprofile of Sonic hedgehog (SHH)-related proteins and the SHH-induced bcl-2 oncoprotein may be able to define the individual KCOT phenotype and biologic behavior. These authors reviewed the current literature regarding possible future molecular oriented treatment.…”

Section: Discussionmentioning

confidence: 99%

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Keratocystic Odontogenic Tumor (KCOT/OKC)—Clinical Guidelines for Resection

Warburton

Shihabi

Ord

2015

J. Maxillofac. Oral Surg.

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Purpose There is no clinical consensus for the treatment of Keratocystic Odontogenic Tumor (KCOT). KCOTs are regarded as benign aggressive tumors and resection is usually considered as a last option. We review the clinical indications for resection based on a case series. Methods This is a retrospective study of patients with KCOT treated in a single unit over 17 years. Eighty patients were identified, of which 12 (15 %) underwent resection. The remaining 68 patients were managed by enucleation and curettage, enucleation with peripheral ostectomy, or decompression with secondary enucleation. Data extracted includes gender, age, race, location, previous treatment for the lesion, surgery and outcome/ follow up. Results Twelve patients treated by resection were identified. The location in the ten benign resected KCOTs was either the mandibular ramus or the posterior maxilla. All mandibular KCOTs exhibited perforation of the lingual plate and involvement of the pterygoid musculature. Seven of the ten cases were recurrent KCOTs and three had no prior treatment. Two had malignant changes in the KCOT and were also resected. Conclusion The primary reason for resection of KCOT was involvement of the pterygoid muscles. The presence of malignant change was a separate indication for resection.

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Section: Discussionmentioning

confidence: 99%

“…Despite their benign classification, molecular analysis of the expression of PTCH, SMO, GlI-1 and bcl-2 in KCOT shows a profile similar to ameloblastoma rather than other odontogenic cysts [5]. In 1994 Jackson et al [6] reported 2 cases of OKC which invaded and penetrated the skull base and led to the death of one of the patients.…”

Section: Introductionmentioning

confidence: 99%

Keratocystic Odontogenic Tumor (KCOT/OKC)—Clinical Guidelines for Resection

Warburton

Shihabi

Ord

2015

J. Maxillofac. Oral Surg.

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“…Discussion of this issue is not a subject of this review, but suggestions that reduced PTCH protein expression may be a marker for OKC, may provide evidence of neoplastic origin, or may distinguish syndromic from non-syndromic cysts have not been borne out. Immunohistochemical studies have shown that PTCH protein expression is similar in OKC, cystic ameloblastomas and other types of odontogenic cysts [27]. There is some evidence emerging that anti-apoptotic markers, including bcl-2 and BAX, may be specifically increased in OKC, but this needs confirmation and its diagnostic value has not been considered [27,28].…”

Section: Neoplastic Odontogenic Epitheliummentioning

confidence: 99%

“…Immunohistochemical studies have shown that PTCH protein expression is similar in OKC, cystic ameloblastomas and other types of odontogenic cysts [27]. There is some evidence emerging that anti-apoptotic markers, including bcl-2 and BAX, may be specifically increased in OKC, but this needs confirmation and its diagnostic value has not been considered [27,28].…”

Section: Neoplastic Odontogenic Epitheliummentioning

confidence: 99%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

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“…It is considered that the main cause for the origin of this lesion is a lack of regulation and a mutation in the PTCH gene 13 .…”

Section: Epidemiology and Etiopathogenesismentioning

confidence: 99%

Keratocystic odontogenic tumor: Clinicopathological aspects and treatment.

Robles¹,

Roa²

2014

Joralres

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Abstract:The keratocystic odontogenic tumor is a benign intraosseous neoplasm derived from remnants of the dental lamina and it occurs with high frequency. Regarding histological characteristics, it has a high recurrence rate which is one of the main therapeutic problems. Also, it presents high local aggressiveness, expressed in cortical expansion, delayed eruption and displacement of teeth, blood vessels and nerves. At present, there are various treatments, being ideal the one which presents the lowest risk of recurrence with low morbidity for the patient. In this review, the main histopathological, clinical and therapeutic aspects of this oral pathology are discussed.

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The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI‐1 and bcl‐2 is similar to ameloblastoma but different from odontogenic cysts

Cited by 61 publications

References 36 publications

Keratocystic Odontogenic Tumor (KCOT/OKC)—Clinical Guidelines for Resection

Keratocystic Odontogenic Tumor (KCOT/OKC)—Clinical Guidelines for Resection

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Keratocystic odontogenic tumor: Clinicopathological aspects and treatment.

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