The immunoregulatory function of polyphenols: implications in cancer immunity

Carvalho, José Tarcísio Giffoni de; Baldivia, Débora da Silva; Castro, David; Santos, Helder Freitas dos; Santos, Cintia Miranda dos; Oliveira, Alex Santos; Alfredo, Tamaeh Monteiro; Vilharva, Kellen Natalice; Souza, Kely de Picoli; Santos, Edson Lucas dos

doi:10.1016/j.jnutbio.2020.108428

Cited by 21 publications

(9 citation statements)

References 99 publications

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“…Lately, targeting the immune system have gained much grounds in the management of cancers in general and immune-based therapies are readily available for cancer treatment. The immunomodulatory activities of polyphenols are well documented ( 334 , 335 ), and they are seen as possible immunoadjuvants ( 257 ). For example, apigenin have been shown to reduce the expression of PD-L1 in melanoma cells ( 336 ) as well as in K-ras mutant lung carcinoma in vivo ( 337 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

Izuegbuna

2022

Front. Nutr.

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Polyphenols are one of the largest plant-derived natural product and they play an important role in plants’ defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to possess antineoplastic properties which include cell cycle arrest, and apoptosis via multiple mechanisms. They also have immunomodulatory activities where they enhance T cell activation and suppress regulatory T cells. They carry out these actions through such pathways as PI3K/Akt/mTOR and the kynurenine. They can also reverse cancer resistance to chemotherapy agents. In this review, i look at some of the molecular mechanism of action of polyphenols and their potential roles as therapeutic agents in hematological malignancies. Here i discuss their anti-proliferative and anti-neoplastic activities especially their abilities modulate signaling pathways as well as immune response in hematological malignancies. I also looked at clinical studies done mainly in the last 10–15 years on various polyphenol combination and how they enhance synergism. I recommend that further preclinical and clinical studies be carried out to ensure safety and efficacy before polyphenol therapies be officially moved to the clinics.

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Section: Future Perspectivesmentioning

confidence: 99%

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

Izuegbuna

2022

Front. Nutr.

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“…Numerous studies revealed the amazing and complex mechanism of the propolis action to preserve/improve human health through the activity of the polyphenolic derivatives [1] , [2] , [3] , [4] , [5] , [6] . Propolis compounds also inhibit some proteins responsible for cancer cells proliferation (e.g., cyclin B, Claudin-2) or activate others involved in the apoptosis process stopping cell division and enhancing the action of cancer drugs [7] .…”

Section: Introductionmentioning

confidence: 99%

Do ultrasonic field effects upon the polyphenolics profile of propolis extracts improve their antioxidant and antimicrobial activity?

Nichitoi

Josceanu

Isopescu

et al. 2023

Ultrasonics Sonochemistry

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“…Moreover, they contain high content of bioactive substances such as flavonols and phenolic acids, particularly anthocyanins and chlorogenic acid (CGA) (Krochmal‐Marczak et al, 2020; Li et al, 2011; Sun et al, 2014). They are dietary antioxidants that act to prevent chronic disorders such as cancer, inflammation, cardiovascular diseases, and diabetes and also help reduce the effects of brain damage (Cadena‐Zamudio et al, 2020; de Carvalho et al, 2020; Liu, Wang, et al, 2020; Pochapski et al, 2011; Rajendra et al, 2011), hence consumption of sweet potato leaves is recommended for healthy well‐being.…”

Section: Introductionmentioning

confidence: 99%

LncRNA‐mediatedceRNAregulatory network provides new insight into chlorogenic acid synthesis in sweet potato

Peng

Pan

Liu

et al. 2022

Physiologia Plantarum

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Sweet potato (Ipomoea batatas L.) is considered a highly nutritional and economical crop due to its high contents of bioactive substances, such as anthocyanin and chlorogenic acid (CGA), especially in leaves and stems. The roles of noncoding RNAs (ncRNA), including long noncoding RNA (lncRNA) and microRNA (miRNA), in CGA synthesis, are still unknown. In this study, the differentially expressed (DE) mRNAs, miRNAs, and lncRNAs in two leafy vegetable genotypes “FS7‐6‐14‐7” (high CGA content) and “FS7‐6” (low CGA content) were identified. The cis‐regulation between lncRNA and mRNA was analyzed. Then, the CGA synthesis‐related modules MEBlue and MEYellow were identified to detect trans‐regulation mRNA‐lncRNA pairs. The GO and KEGG annotations suggested that mRNA in these two modules was significantly enriched in the secondary metabolite synthesis biosynthesis category. A competing endogenous RNAs (ceRNA) network, including 8730 miRNA‐mRNA and 444 miRNA‐lncRNA pairs, was constructed by DEmiRNA target prediction. Then, a CGA synthesis‐related ceRNA network was obtained with lncRNA and mRNA from MEBlue and MEYellow. Finally, one relational pair, MSTRG.47662.1/mes‐miR398/itb04g00990, was selected for functional validation. Overexpression of lncRNA MSTRG.47662.1 and mRNA itb04g00990 increased CGA content in both tobacco and sweet potato callus, while overexpression of miRNA mes‐miR398 decreased CGA content. Meanwhile, regression analysis of the expression patterns demonstrated that MSTRG.47662.1, acting as a ceRNA, promoted itb04g00990 expression by competitively binding mes‐miR398 in CGA synthesis in sweet potato. Our results provide insights into how ncRNA‐mediated ceRNA regulatory networks likely contribute to CGA synthesis in leafy sweet potato.

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The immunoregulatory function of polyphenols: implications in cancer immunity

Cited by 21 publications

References 99 publications

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

Do ultrasonic field effects upon the polyphenolics profile of propolis extracts improve their antioxidant and antimicrobial activity?

LncRNA‐mediatedceRNAregulatory network provides new insight into chlorogenic acid synthesis in sweet potato

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