2023
DOI: 10.3390/life13061310
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The Immunotherapeutic Role of Type I and III Interferons in Melanoma and Non-Melanoma Skin Cancers

Abstract: Interferons (IFNs) have demonstrated therapeutic potential in various skin cancers, specifically squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma. The precise mechanism through which type I IFNs exert their antitumor effects in skin cancers is still being studied. However, intralesional type I IFN can be used as an alternative to surgery for select patient populations, and high-dose systemic IFN therapy has been shown to be promising in patients with operable high-risk or metastatic mela… Show more

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Cited by 5 publications
(3 citation statements)
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“…ECT with bleomycin has demonstrated superior response rates compared to other cutaneous tumors, with acceptable outcomes in terms of cosmesis and tissue-sparing benefits [ 33 ]. While methotrexate and interferon therapy have shown limited efficacy in BCC treatment, further investigation is warranted to elucidate their role in this context [ 38 , 41 ].…”
Section: Discussionmentioning
confidence: 99%
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“…ECT with bleomycin has demonstrated superior response rates compared to other cutaneous tumors, with acceptable outcomes in terms of cosmesis and tissue-sparing benefits [ 33 ]. While methotrexate and interferon therapy have shown limited efficacy in BCC treatment, further investigation is warranted to elucidate their role in this context [ 38 , 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…Both Type I and Type III IFNs appear to elicit a similar response and utilize the same signaling pathways, but their difference lies in their specific response, as they act on receptors in different locations. While there are presently no studies investigating the use of intralesional IFN-lambda in the treatment of NMSC, type I IFNs have been extensively researched for decades [ 17 , 40 , 41 , 42 ].…”
Section: Clinical Scenarios and Indications For The Use Of Topical An...mentioning
confidence: 99%
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