The impact and measurement of social dysfunction in late‐life depression: an evaluation of current methods with a focus on wearable technology

Hodgetts, Sophie; Gallagher, Peter; Stow, Daniel; Ferrier, I. Nicol; O’Brien, John T.

doi:10.1002/gps.4632

Cited by 20 publications

(18 citation statements)

References 77 publications

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“…Differences in depressive symptom ascertainment, study occupation or population, SW definition, and study design make comparisons to other studies difficult. However, previous literature indicates that common complaints among shiftworkers, include, increased stress, sleep and circadian disruption, and poor social functioning, which are all associated with depression or depressive symptoms (Germain & Kupfer, 2008; Hodgetts, Gallagher, Stow, Ferrier, & O’Brien, 2016). …”

Section: Discussionmentioning

confidence: 99%

The Dietary Inflammatory Index, shift work, and depression: Results from NHANES.

Wirth¹,

Shivappa²,

Burch³

et al. 2017

Health Psychology

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Objectives Abnormal physiology (e.g., inflammation), brought on by environmental exposures (e.g., diet or shiftwork [SW]), can affect numerous bodily systems, including the brain, and may be associated with depressive symptomatology. The study examined the associations between shiftwork and depressive symptoms and diet-related inflammation (estimated by the Dietary Inflammatory Index [DII]TM) and depressive symptoms. Additionally, diet was examined as a mediator between shiftwork and depressive symptoms. Methods Data were obtained from the United States National Health and Nutrition Examination Survey (2005–2012). SW data were based on self-report. Dietary data were collected using 24-hour dietary recalls for DII calculation. Depressive symptoms were defined using a cut-point of 10 (moderate) on the Patient Health Questionnaire-9. Logistic regression was used to estimate odds ratios and 95% confidence intervals (95%CI) for depressive symptoms by SW and DII quartiles. Results DII scores were associated with depressive symptoms among women. Women in DII quartile 4 were 30% more likely to report depressive symptoms than women in quartile 1 (95%CI=1.00–1.68). There was no association between symptoms and SW when using a PHQ-9 cut-point of 10. When using a cut-point of 5 (mild depressive symptoms), those working any form of shiftwork were more likely to suffer from mild symptoms than day workers (odds ratio=1.22; 95%CI=1.04–1.43). There was some evidence for mediation by the DII between SW and depressive symptoms. Conclusions Future longitudinal studies should examine effects of reductions in inflammation through diet on depressive symptoms, especially among shiftworkers, to elucidate the role of diet on depression among these groups.

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Section: Discussionmentioning

confidence: 99%

The Dietary Inflammatory Index, shift work, and depression: Results from NHANES.

Wirth¹,

Shivappa²,

Burch³

et al. 2017

Health Psychology

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“…Motivational symptoms such as psychomotor retardation, anergia, lack of energy, lassitude, fatigue, and reduced exertion of effort are common and critical in major depressive disorder (Stahl, 2002;Demyttenaere et al, 2005;Salamone et al, 2007;Treadway and Zald, 2011). These highly debilitating symptoms in depression are strongly correlated with problems with social function and employment (Tylee, 1999;Stahl, 2002Stahl, , 2017Hodgetts et al, 2017). They are also highly resistant to treatment and often remain as residual symptoms after remission (Stahl, 2002;Nutt et al, 2007;Fava et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion

Carratalá-Ros

López-Cruz

Martínez-Verdú

et al. 2021

Front. Behav. Neurosci.

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Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low effort activities. To determine if the broadly used antidepressant fluoxetine can improve behavioral activation and reverse dopamine (DA) depletion-induced anergia, male CD1 mice were evaluated for vigorous escape behaviors in an aversive context (forced swim test, FST), and also with an exercise preference choice task [running wheel (RW)-T-maze choice task]. In the FST, fluoxetine increased active behaviors (swimming, climbing) while reducing passive ones (immobility). However, fluoxetine was not effective at reducing anergia induced by the DA-depleting agent tetrabenazine, further decreasing vigorous climbing and increasing immobility. In the T-maze, fluoxetine alone produced the same pattern of effects as tetrabenazine. Moreover, fluoxetine did not reverse tetrabenazine-induced suppression of RW time but it reduced sucrose intake duration. This pattern of effects produced by fluoxetine in DA-depleted mice was dissimilar from devaluing food reinforcement by pre-feeding or making the food bitter since in both cases sucrose intake time was reduced but animals compensated by increasing time in the RW. Thus, fluoxetine improved escape in an aversive context but decreased relative preference for active reinforcement. Moreover, fluoxetine did not reverse the anergic effects of DA depletion. These results have implications for the use of fluoxetine for treating motivational symptoms such as anergia in depressed patients.

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“…The elevated risk observed in non-users, compared to the lowest cumulative dose (DDD 1-91), weakens the hypothesis that drug effects explain our findings. Patients with depression are less active in everyday social life, 48 which might also include activities involving UVR exposure. As far as we know, neither depression nor use of antidepressants has been associated with altered habits of outdoor activity and reduced UVR exposure.…”

Section: Discussionmentioning

confidence: 99%

<p>Use of Antidepressants and Risk of Cutaneous Melanoma: A Prospective Registry-Based Case-Control Study</p>

Berge¹,

Andreassen²,

Stenehjem³

et al. 2020

CLEP

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Purpose: Melanoma is the cancer with the most rapidly rising incidence rate in Norway. Although exposure to ultraviolet radiation (UVR) is the major environmental risk factor, other factors may also contribute. Antidepressants have cancer inhibiting and promoting side effects, and their prescription rates have increased in parallel with melanoma incidence. Thus, we aimed to prospectively examine the association between use of antidepressants and melanoma by using nationwide data from the Cancer Registry of Norway, the National Registry, the Norwegian Prescription Database and the Medical Birth Registry of Norway. Patient and Methods: All cases aged 18-85 with a primary cutaneous invasive melanoma diagnosed during 2007-2015 (n=12,099) were matched to population controls 1:10 (n=118,467) by sex and year of birth using risk-set sampling. We obtained information on prescribed antidepressants and other potentially confounding drug use (2004-2015). Conditional logistic regression was used to estimate adjusted rate ratios (RRs) and 95% confidence intervals (CIs) for the association between overall and class-specific use of antidepressants and incident melanoma. Results: Compared with ≤1 prescription, ≥8 prescriptions of antidepressants overall were negatively associated with melanoma (RR 0.81 CI 0.75-0.87). Class-specific analyses showed decreased RRs for selective serotonin reuptake inhibitors (RR 0.82 CI 0.73-0.93) and mixed antidepressants (RR 0.77 CI 0.69-0.86). The negative association was found for both sexes, age ≥50 years, residential regions with medium and highest ambient UVR exposure, all histological subtypes, trunk, upper and lower limb sites and local disease. Conclusion: Use of antidepressants was associated with decreased risk of melanoma. There are at least two possible explanations for our results; cancer-inhibiting actions induced by the drug and less UVR exposure among the most frequent users of antidepressants.

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The impact and measurement of social dysfunction in late‐life depression: an evaluation of current methods with a focus on wearable technology

Cited by 20 publications

References 77 publications

The Dietary Inflammatory Index, shift work, and depression: Results from NHANES.

The Dietary Inflammatory Index, shift work, and depression: Results from NHANES.

Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion

<p>Use of Antidepressants and Risk of Cutaneous Melanoma: A Prospective Registry-Based Case-Control Study</p>

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