The impact of a cold pressor test on brachial artery handgrip exercise-induced flow-mediated dilation

Stuckless, Troy J.R.; Pyke, Kyra E.

doi:10.1177/1358863x15586473

Cited by 13 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…) and have been shown not to influence SFA RH‐FMD or brachial artery HGEX‐FMD in young men (Thijssen et al . ; Stuckless & Pyke, ). This suggests that any small increase in sympathetic nervous activity over the trials was unlikely to influence SFA‐FMD.…”

Section: Discussionmentioning

confidence: 99%

Assessment of flow‐mediated dilatation in the superficial femoral artery using a sustained shear stress stimulus via calf plantar‐flexion exercise

King

Schmitter

Pyke

2017

Experimental Physiology

View full text Add to dashboard Cite

What is the central question of this study? The aim was to establish the ability of a newly designed leg exercise technique to produce sustained elevations in shear rate that stimulate flow-mediated dilatation (FMD) in the superficial femoral artery and to determine the repeat trial stability of the FMD response. What is the main finding and its importance? Calf plantar-flexion exercise can be used to increase shear stress and stimulate FMD in the superficial femoral artery. However, the magnitude of FMD varied systematically when multiple trials were repeated in short succession. The superficial femoral artery (SFA) is susceptible to vascular disease, and a technique to assess flow-mediated dilatation (FMD) in this vessel in response to a sustained shear stress stimulus could provide important information about endothelial function. The aim of this study was to establish the ability of a newly designed SFA leg exercise-FMD (LEX-FMD) technique to produce sustained elevations in shear rate, which stimulate FMD, and to determine the repeat trial stability of the FMD response. The SFA FMD stimulated by reactive hyperaemia (RH) and calf plantar-flexion exercise (LEX) was assessed via ultrasound in 19 healthy men (n = 10) and women (n = 9). The two experimental visits included either four trials of LEX-FMD or four trials of RH-FMD. The shear stress stimulus was estimated as the shear rate (blood velocity/SFA diameter). Results are expressed as the means ± SD. The LEX steady-state shear rate was consistent between trials (P = 0.176), whereas the RH shear rate area under the curve was higher in trial 1 versus trials 2-4 (P < 0.05). The %RH-FMD (four-trial mean 4.9 ± 2.5%) and absolute RH-FMD were not significantly different between trials (P = 0.465 and P = 0.359, respectively). Both %LEX-FMD and absolute LEX-FMD were higher during trial 3 (4.8 ± 3.4%) than trial 1 (3.6 ± 2.7%; P = 0.026 and P = 0.026, respectively). The magnitude of RH-FMD and LEX-FMD did not differ (P = 0.241). These results indicate that calf plantar-flexion exercise can be used to increase shear stress and stimulate FMD in the SFA. However, although SFA RH-FMD was stable across four trials, LEX-FMD varied systematically when multiple trials were repeated in rapid succession.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of flow‐mediated dilatation in the superficial femoral artery using a sustained shear stress stimulus via calf plantar‐flexion exercise

King

Schmitter

Pyke

2017

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…resistance vessels. lower body negative pressure; Hijmering et al, 2002), but this has not been shown consistently (Dyson, Shoemaker, & Hughson, 2006) and has not been shown for SS-FMD (Stuckless & Pyke, 2015); therefore, it is unlikely that any small increase in sympathetic nervous activity, if present, had an influence on our FMD observations. Accepting this assertion, the 30 min handgrip exercise intervention would recruit the 'sustained (calcium-independent) pathway' .…”

Section: Impact Of Congruity Between the Intervention And Fmd Testingmentioning

confidence: 62%

“…Interventions that result in very substantial elevations in sympathetic nervous activity have been reported to impair RH-FMD (e.g. lower body negative pressure; Hijmering et al, 2002), but this has not been shown consistently (Dyson, Shoemaker, & Hughson, 2006) and has not been shown for SS-FMD (Stuckless & Pyke, 2015); therefore, it is unlikely that any small increase in sympathetic nervous activity, if present, had an influence on our FMD observations.…”

Section: Impact Of Congruity Between the Intervention And Fmd Testingmentioning

confidence: 72%

Thirty minutes of handgrip exercise potentiates flow‐mediated dilatation in response to sustained and transient shear stress stimuli to a similar extent

McPhee

Pyke

2018

Experimental Physiology

View full text Add to dashboard Cite

Brief (30 min) exposure of the brachial artery (BA) to a sustained elevation in shear stress has been shown to potentiate subsequent BA flow-mediated dilatation (FMD) in response to a transient shear stress stimulus [reactive hyperaemia (RH) FMD]. It is unknown whether matching the sustained shear stress exposure to a subsequent sustained shear stress stimulus for FMD [via handgrip exercise (SS-FMD)] might enhance the potentiation of FMD. The purpose of the study, therefore, was to assess the impact of a 30 min handgrip exercise intervention-induced elevation in shear stress on subsequent BA SS-FMD versus RH-FMD. Nineteen healthy men (22 ± 3 years) preformed a 30 min rhythmic handgrip exercise intervention on two experimental days. BA-FMD was assessed using either an RH or a 6 min sustained shear stress stimulus created via handgrip exercise (order of visits counterbalanced) at three time points: pre-intervention and 10 and 60 min post-intervention. The FMD was assessed using duplex ultrasound. Shear stress was estimated as shear rate (SR = BA blood velocity/BA diameter). Data are mean ± SD. Both SS and RH-FMD increased from pre-intervention to 10 min post-intervention [SS-FMD (6 min average), from 0.11 ± 0.05 to 0.16 ± 0.08 mm; P = 0.008; Cohen's d = 0.66; and RH-FMD, from 0.25 ± 0.1 to 0.32 ± 0.11 mm; P = 0.013; Cohen's d = 0.68]. The magnitude of enhancement in RH and SS-FMD did not differ (change in RH versus SS-FMD pre- versus 10 min post-intervention, P = 0.344). These findings suggest that exposure to elevated shear stress via 30 min of handgrip exercise potentiates subsequent FMD in response to sustained and transient elevations in shear stress to a similar extent.

show abstract

“…It has been revealed that the cold pressor test (CPT) evaluates the sympathetic reactivity of the cardiovascular system during the immersion of a hand in cold water [17,18]. The CPT has been used as a potential sympathoexcitatory stimulus in several studies [19][20][21][22]. The CPT also increases aortic PWV and the aortic augmentation index in young and older adults [23,24], suggesting that noninvasively arterial stiffness parameters are altered by the CPT.…”

Section: Introductionmentioning

confidence: 99%

Cold Pressor Test Influences the Cardio-Ankle Vascular Index in Healthy Overweight Young Adults

Kulthinee

Nernpermpisooth

Poomvanicha

et al. 2021

Pulse

View full text Add to dashboard Cite

Objective: The cold pressor test (CPT) has been shown a potential sympathoexcitatory stimulus which increases aortic pulse wave velocity and the aortic augmentation index, suggesting that noninvasively, arterial stiffness parameters are altered by the CPT. The cardio-ankle vascular index (CAVI) is widely used for reflecting arterial stiffness, and the ankle-brachial index (ABI) for evaluating peripheral artery disease in obesity. We aimed to assess CAVI and ABI in overweight young adults in the context of sympathetic activation by using the CPT. Methods: 160 participants were divided into 2 groups: 86 normal-weight (body mass index [BMI] 18.50–22.99 kg/m2) and 74 overweight (BMI ≥23 kg/m2). The CPT was performed by immersing a participant’s left hand into cold water (3–5°C) for 3 min, and CAVI and ABI assessment. Results: At baseline, the CAVI in the overweight group was significantly less than that in the normal-weight group (5.79 ± 0.85 vs. 6.10 ± 0.85; p < 0.05). The mean arterial pressure (MAP) for overweight was significantly greater than that for normal-weight subjects (93.89 ± 7.31 vs. 91.10 ± 6.72; p < 0.05). During the CPT, the CAVI increased in both normal-weight and overweight subjects, the CAVI value was greater during the CPT in overweight subjects by 14.36% (6.62 ± 0.95 vs. 5.79 ± 0.85, p < 0.05) and in normal-weight subjects by 8.03% (6.59 ± 1.20 vs. 6.10 ± 0.85, p < 0.05) than those baseline values. The CPT evoked an increase in systolic blood pressure (SBP), diastolic BP (DBP), heart rate (HR,) and pulse pressure (PP) in both groups. After a 4-min CPT period, the CAVI returned values similar to the baseline values in both groups, and the SBP, DBP, MAP, and PP in overweight participants were significantly higher than those in normal-weight participants. However, there was no significant difference in the ABI at baseline, during CPT, and post-CPT in either group. Conclusions: Our results indicated that the CAVI was influenced by sympathetic activation response to the CPT in both normal-weight and overweight young adults. Specifically, during the CPT, the percentage change of the CAVI in overweight response was greater in normal-weight participants than baseline values in each group. The ABI was not found significantly associated with CPT. These findings suggesting that sympathoexcitatory stimulus by CPT influence CAVI results.

show abstract

The impact of a cold pressor test on brachial artery handgrip exercise-induced flow-mediated dilation

Cited by 13 publications

References 42 publications

Assessment of flow‐mediated dilatation in the superficial femoral artery using a sustained shear stress stimulus via calf plantar‐flexion exercise

Assessment of flow‐mediated dilatation in the superficial femoral artery using a sustained shear stress stimulus via calf plantar‐flexion exercise

Thirty minutes of handgrip exercise potentiates flow‐mediated dilatation in response to sustained and transient shear stress stimuli to a similar extent

Cold Pressor Test Influences the Cardio-Ankle Vascular Index in Healthy Overweight Young Adults

Contact Info

Product

Resources

About