The impact of a family history of prostate cancer on the prognosis and features of the disease in Korea: results from a cross-sectional longitudinal pilot study

Lee, Kwang Suk; Koo, Kyo Chul; Chung, Byung Ha

doi:10.1007/s11255-017-1696-6

Cited by 7 publications

(9 citation statements)

References 29 publications

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“…Research from Sweden demonstrated that around 11.63% of PCa were familial . However, Lee et al reported that only 3.8% of PCa patients had positive FH in South Korea . Our study based on Chinese population shows similar positive rate of FH (4.5%) as that in South Korea.…”

Section: Discussionsupporting

confidence: 69%

Family history is significantly associated with prostate cancer and its early onset in Chinese population

Huang

et al. 2019

The Prostate

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Background: Family history (FH) of prostate cancer (PCa) in Chinese population is poorly understood. The objective of this study is to evaluate the association between FH and PCa in a Chinese biopsy cohort.Methods: Consecutive patients who received 10 to 12 core systematic prostate biopsies from April 2013 to October 2018 in three medical centers were enrolled in this study.Demographic information and clinical information were obtained through prebiopsy questionnaire, including cancer FH, age, and total prostate-specific antigen (tPSA).Results: Of 2321 patients, 83 (3.6%) were reported a FH of PCa. The positive biopsy rate in these patients was 54.2%, significantly higher than the patients without the family history of PCa (42.6%; relative risk [RR] = 1.27; P = .024). In patients with positive FH of breast cancer gene (BRCA)-related cancers (breast, ovarian, and prostate cancer, n = 154), 74 (48.1%) were diagnosed as PCa, higher than those without FH (42.7%; RR = 1.13; P = .112). Multivariate logistic regression analysis (after adjusting for age and tPSA values) showed that there was 2.1-fold increased risk of PCa in patients with positive FH of PCa (P = .005), and 1.6-fold increased risk in patients with positive FH of BRCA-related cancers (P = .019). However, there was no significant association between FH of PCa or BRCArelated cancer and high-grade PCa after adjusting age and tPSA level (P = .404 for PCa, P = 0.991 for BRCA-related cancers). Conclusions: Patients with positive FH of PCa had 2.1-fold higher risk of PCa, and patients with positive FH of BRCA-related cancers had 1.6-fold higher risk in this biopsy cohort of Chinese population. Patients with positive FH of PCa or BRCArelated cancers would have earlier age at onset of PCa.

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Section: Discussionsupporting

confidence: 69%

Family history is significantly associated with prostate cancer and its early onset in Chinese population

Huang

et al. 2019

The Prostate

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“…Furthermore, family history had no prognostic effect on biochemical failure. However, our previous study confined the study population to those who have undergone radical prostatectomy [19]. Therefore, the prostate cancer was more aggressive in those group compared to the study population in this study and this might be the reason why the family history was reported as significant predictor of clinically significant prostate cancer with higher Gleason scores only in this study.…”

Section: Discussionmentioning

confidence: 70%

“…Therefore, a positive family history was associated with aggressive features of the disease at diagnosis. However, our group previously reported that the presence of a family history was not identified as a prognostic factor of overall survival for prostate cancer among Korean population [19]. Additionally, no statistically significant differences were found in several parameters, including the Gleason score and pathologic stage, tumour volume, and positive surgical margin, between patients with and without a family history.…”

Section: Discussionmentioning

confidence: 87%

The association of family history of prostate cancer with the diagnosis of clinically significant prostate cancer in Korean population

et al. 2019

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PurposeThe impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer.Materials and MethodsPatients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history.ResultsOf 602 patients (median age, 68.3 years; median prostate-specific antigen level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio [OR], 2.99; 95% confidence interval [CI], 1.330–6.704; p=0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR, 6.32; 95% CI; 2.790–14.298; p<0.001).ConclusionsA family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history.

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“…The individual relative risk of a PCa diagnosis is doubled in first-degree male relatives of PCa patients [2], and 10-20% of PCa patients are reported to have a positive family history among their first-degree relatives [3]. Although numerous studies have focused on the clinicopathological features associated with family history of PCa [4][5][6], clinical observation has shown no substantial differences between PCa patients with family history and those without, except that family history is associated with younger age at diagnosis [2]. Recent findings point to genetic factors that underlie familial aggregations of PCa; genetic differences between patients with and without family history of PCa can be based on single-nucleotide polymorphisms or germline mutations, including HOXB13, BRCA1, BRCA2, and MLH1, which are associated with an increased risk of familial PCa [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Impact of family history on oncological outcomes in primary therapy for localized prostate cancer patients: a systematic review and meta-analysis

Urabe

Kimura

Yamamoto

et al. 2021

Prostate Cancer Prostatic Dis

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Background The influence of family history on oncological outcomes of prostate cancer remains controversial. We conducted a systematic literature review and meta-analysis to investigate the impact of family history of localized prostate cancer on oncological outcomes. Methods On May 2020, we systematically searched MEDLINE, the Cochrane library, and Scopus for studies that compared patients who had localized prostate cancer with or without a positive family history of prostate cancer. Our aim was to evaluate the association of family history with biochemical recurrence-free survival, cancer-specific survival, and overall survival by means of a multivariate Cox regression analysis. Results Eleven studies with 39,716 patients were included in the systematic review, and eight studies with 33,027 patients for the meta-analysis. A positive family history was not associated with worse biochemical recurrence-free survival (pooled HR: 0.96; 95% CI: 0.79–1.17) or cancer-specific survival (pooled HR: 1.1; 95% CI: 0.52–2.35). Subgroup analyses showed no association between positive family history and poor biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy (pooled HR: 0.99; 95% CI: 0.76–1.31) or radiation therapy (pooled HR: 0.93; 95% CI: 0.67–1.30). Conclusions This meta-analysis indicated that family history of prostate cancer does not increase the risk of biochemical recurrence or cancer-specific mortality in localized prostate cancer patients.

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The impact of a family history of prostate cancer on the prognosis and features of the disease in Korea: results from a cross-sectional longitudinal pilot study

Abstract: A family history of prostate cancer seemed to have no effect on prognosis and disease aggressiveness. However, this study proposed a rationale for performing earlier prostate-specific antigen testing in men with a family history of prostate cancer.

Cited by 7 publications

References 29 publications

Family history is significantly associated with prostate cancer and its early onset in Chinese population

Family history is significantly associated with prostate cancer and its early onset in Chinese population

The association of family history of prostate cancer with the diagnosis of clinically significant prostate cancer in Korean population

Impact of family history on oncological outcomes in primary therapy for localized prostate cancer patients: a systematic review and meta-analysis

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