The Impact of a Negative
            <sup>111</sup>
            Indium-Capromab Pendetide Scan Before Salvage Radiotherapy

Proano, Juan M; Sodee, D. Bruce; Resnick, Martin I.; Einstein, Douglas B.

doi:10.1016/s0022-5347(05)00982-1

Cited by 22 publications

(7 citation statements)

References 16 publications

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“…Men with negative RIS scans were more likely to have a durable response with salvage radiotherapy. Consistent with other studies, 45,46 70% were biochemically controlled if there was no uptake seen outside the prostatic fossa compared to 22% of patients controlled when there was uptake outside the prostatic fossa and pelvis (P=0.0225). However, many of these studies had relatively short follow-up, and standard prognostic factors were in many cases not balanced between those with negative and positive RIS scans, limiting the ability to determine how much of the difference in outcome was due to RIS findings and how much was due to differences in prognostic factors.…”

Section: Cancer Control and Toxicity Outcomessupporting

confidence: 88%

The Role of Indium-111 Radioimmunoscintigraphy in Post-Radical Retropubic Prostatectomy Management of Prostate Cancer Patients

Jani¹,

Liauw²,

Blend³

2007

Clinical Medicine & Research

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Indium-111 radioimmunoscintigraphy (RIS) has an increasing role in the treatment of prostate cancer and is most commonly performed at this disease site using labeled monoclonal antibody against prostate-specific membrane antigen. There are many limitations of RIS, including low spatial resolution, low diagnostic yield and limited availability. Despite these limitations, the efficacy of RIS has been demonstrated in many clinical studies, including multi-institutional investigations. The highest sensitivity and specificity of RIS appears to be in the post-radical retropubic prostatectomy (post-RRP) setting. RIS has recently been explored for its role in clinical radiotherapy decision-making, and was found to have a significant impact in selecting patients for radiotherapy and for the general radiotherapy treatment volume definition. RIS has also recently been explored for its role in radiotherapy planning and was found to impact clinical target volume design. However, manual editing of the RIS volume is still necessary when projected into the radiotherapy-planning scan, as there is often overlap in the RIS-defined uptake regions with normal structures (rectum, bladder and symphysis bone marrow). The impact of RIS on biochemical control has been explored, with studies in this area yielding conflicting results. It appears that the maximum impact of RIS is possible when areas of labeled antibody uptake regions are co-registered with the radiotherapy-planning computed tomography scan.The larger RIS-guided target volumes do not appear to be prohibitive in increasing radiotherapy-related toxicity. Future directions of the use of RIS for post-RRP prostate cancer are discussed.

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Section: Cancer Control and Toxicity Outcomessupporting

confidence: 88%

The Role of Indium-111 Radioimmunoscintigraphy in Post-Radical Retropubic Prostatectomy Management of Prostate Cancer Patients

Jani¹,

Liauw²,

Blend³

2007

Clinical Medicine & Research

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“…111 In-capromab pendetide (ProstaScint) has been evaluated retrospectively in several studies. The results have been mixed, with some studies showing a better prognosis in the absence of uptake or solely intrapelvic uptake (48,49), and others failing to reveal any link between the radioimmunoscintigraphy results and biochemical progression-free survival (50)(51)(52)(53). The 11 C-choline positron emission tomography technique appears to be of use but is handicapped by the cameras' low spatial resolution-this makes it difficult to detect low-volume lesions and results in a poor negative predictive value (54).…”

Section: Salvage Rtmentioning

confidence: 99%

Adjuvant and Salvage Radiotherapy After Prostatectomy for Prostate Cancer: A Literature Review

Pasquier¹,

Ballereau²

2008

International Journal of Radiation Oncology*Biology*Physics

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“…To select patients for salvage radiotherapy for recurrence after prostatectomy, the 111 In-capromab pendetide scintigraphy (Prostascint) has been used (5,6). There are no data about the efficacy of this type of scintigraphy in cases of recurrence after external-beam radiotherapy (EBRT).…”

Section: Introductionmentioning

confidence: 99%

Detection of Local, Regional, and Distant Recurrence in Patients With PSA Relapse After External-Beam Radiotherapy Using 11C-Choline Positron Emission Tomography

Breeuwsma

Pruim

Bergh

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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The Impact of a Negative ¹¹¹ Indium-Capromab Pendetide Scan Before Salvage Radiotherapy

Abstract: Our early experience supports an improved prognosis in patients receiving salvage pelvic radiotherapy for biochemical recurrence after RP who have a negative pre-radiotherapy ProstaScint scan. However, this finding is not necessarily independent of pre-radiotherapy PSA.

Cited by 22 publications

References 16 publications

The Role of Indium-111 Radioimmunoscintigraphy in Post-Radical Retropubic Prostatectomy Management of Prostate Cancer Patients

The Role of Indium-111 Radioimmunoscintigraphy in Post-Radical Retropubic Prostatectomy Management of Prostate Cancer Patients

Adjuvant and Salvage Radiotherapy After Prostatectomy for Prostate Cancer: A Literature Review

Detection of Local, Regional, and Distant Recurrence in Patients With PSA Relapse After External-Beam Radiotherapy Using 11C-Choline Positron Emission Tomography

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The Impact of a Negative 111 Indium-Capromab Pendetide Scan Before Salvage Radiotherapy

Abstract: Our early experience supports an improved prognosis in patients receiving salvage pelvic radiotherapy for biochemical recurrence after RP who have a negative pre-radiotherapy ProstaScint scan. However, this finding is not necessarily independent of pre-radiotherapy PSA.

Cited by 22 publications

References 16 publications

The Role of Indium-111 Radioimmunoscintigraphy in Post-Radical Retropubic Prostatectomy Management of Prostate Cancer Patients

The Role of Indium-111 Radioimmunoscintigraphy in Post-Radical Retropubic Prostatectomy Management of Prostate Cancer Patients

Adjuvant and Salvage Radiotherapy After Prostatectomy for Prostate Cancer: A Literature Review

Detection of Local, Regional, and Distant Recurrence in Patients With PSA Relapse After External-Beam Radiotherapy Using 11C-Choline Positron Emission Tomography

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Product

Resources

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The Impact of a Negative ¹¹¹ Indium-Capromab Pendetide Scan Before Salvage Radiotherapy