The Impact of a New ATS/IDSA Guideline for Nontuberculous Mycobacterial Disease on the Diagnosis of Nontuberculous Mycobacterial Lung Disease in Korea

Chae, Dong-Ryeol

doi:10.1378/chest.10800

Cited by 2 publications

(2 citation statements)

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“…The potentially weaker constitution of women might contribute to a lower resistance against infections, serving as a potential risk factor for NTM lung disease development. This observation warrants further investigation, aligning with studies conducted by Zheng LY [13] and Chen XH [14];Occupational groups such as farmers, frequently exposed to soil and water through their work environment, may be at heightened risk of NTM infection due to increased environmental contact.Abnormal BMI, whether low or high, can impair immune system function. A high BMI could be associated with COPD and diabetes, which may in uence the onset of either NTM or TB infections.Clinical symptoms like dyspnea, loss of appetite, and fever may re ect varying stages of disease progression and pathophysiological mechanisms.…”

Section: Discussionsupporting

confidence: 78%

Construction of a prediction model for Non-tuberculous mycobacterial lung disease based on clinical characteristics and analysis of its application value

Liu,

Han,

Cheng

et al. 2024

Preprint

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Objective The objective of this study was to explore the differential clinical features between Nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis (PTB), and to develop a predictive model for the differential diagNosis of these two conditions. The study aimed to provide clinical guidance for the diagNosis and treatment of NTM-PD. Methods The study included 145 patients with NTM-PD and 206 patients with PTB, whose clinical characteristics,imaging findings,and inflammatory markers were compared.A binary logistic regression model was used to analyze the influencing factors and evaluate the predictive performance and calibration accuracy of the model. Results A comparative analysis of clinical, imaging, and inflammatory markers between NTM-PD and PTB groups revealed significant differences in demographics (age, gender, occupation, BMI), symptoms (dyspnea, loss of appetite, fever), risk factors (smoking, alcohol consumption history, diabetes), and comorbidities (bronchiectasis, emphysema, COPD, cystic-columnar, honeycomb, lung cavitation, MONo%; P < 0.05). Multivariate binary logistic regression identified gender and diabetes as protective, while bronchiectasis, COPD, and lung cavitation as risk factors. The model's predictive performance was strong with an AUC of 0.874 (95% CI 0.837 ~ 0.910; P < 0.001) and a Youden index of 0.611, yielding sensitivity of 83.4% and specificity of 77.7%. Model calibration was assessed by the Hosmer-Lemeshow test, showing no significant difference between predicted and observed values (χ²=7.895, P = 0.444 > 0.05). Conclusion In female patients without diabetes or underlying conditions such as bronchiectasis or COPD, when high-resolution computed tomography (HRCT) of the chest reveals predominantly cavitated lesions, it is imperative to give high priority to the differential diagnosis for possible NTM-PD, given its clinical resemblance to PTB. A meticulous distinction between these diagnoses is essential during the diagnostic process to prevent misdiagnosis.

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Section: Discussionsupporting

confidence: 78%

Construction of a prediction model for Non-tuberculous mycobacterial lung disease based on clinical characteristics and analysis of its application value

Liu,

Han,

Cheng

et al. 2024

Preprint

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“…The latter two issues make improper identification of NTM a persisting challenge in the Gulf region, as evident from several case studies [ 30 , 60 ]. Thus, to ensure a prompt recognition of NTM cases in this geographic region, the NTM diagnostic criteria (ATS/IDSA, 2007) should be tested, similar to what has been done elsewhere, and accordingly optimized [ 61 ]. This is especially imperative since not all NTM species relevant in countries of the GCC are represented in the ATS/IDSA 2007 criteria.…”

Section: Challenges In Diagnosing Ntm Diseasesmentioning

confidence: 99%

Nontuberculous Mycobacteria in Saudi Arabia and Gulf Countries: A Review

Al-Ghafli

Al‐Hajoj

2017

Canadian Respiratory Journal

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Nontuberculous Mycobacteria (NTM) are causing growing health problems worldwide. This is indicated by an increasing amount of scientific reports showing not only well-identified species reemerging but also emergence of new species. The emergence and reemergence of NTM are particularly worrying in developing countries due to scarce published data and improper identification. Here we aimed to examine the main epidemiological aspects and diagnostic challenges associated with NTM in countries of the Gulf Cooperation Council (GCC) and compare these findings to the international arena findings. Data revealed that countries of the GCC are largely dominated by rapidly growing mycobacteria species such as M. fortuitum (29%) and M. abscessus (17%) with high rate of definitive respiratory diseases. On the other hand, most of the developed countries are dominated by slowly growing mycobacteria such as MAC, M. kansasii, and M. gordonae. More efforts are needed, however, to gain insights into NTM issues in countries of the GCC.

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The Impact of a New ATS/IDSA Guideline for Nontuberculous Mycobacterial Disease on the Diagnosis of Nontuberculous Mycobacterial Lung Disease in Korea

Cited by 2 publications

References 0 publications

Construction of a prediction model for Non-tuberculous mycobacterial lung disease based on clinical characteristics and analysis of its application value

Construction of a prediction model for Non-tuberculous mycobacterial lung disease based on clinical characteristics and analysis of its application value

Nontuberculous Mycobacteria in Saudi Arabia and Gulf Countries: A Review

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