The impact of a specific blend of essential oil components and sodium butyrate in feed on growth performance and Salmonella counts in experimentally challenged broilers

Cerisuelo, A.; Marín, Clara; Sánchez‐Vizcaíno, Fernando; Gómez, Ernesto A.; Fuente, J M de la; Durán, R. R.; Fernández, Carlos

doi:10.3382/ps.2013-03528

Cited by 77 publications

(56 citation statements)

References 32 publications

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“…Similar comparable caecal pH was also recorded when 0.03 % fat coated SB (Smulikowska et al, 2009) and 0.1 % SB together with essential oil (Cerisuelo et al, 2014) were used in broiler ration.…”

Section: Advances In Animal and Veterinary Sciencessupporting

confidence: 76%

Butyric Acid as an Antibiotic Substitute for Broiler Chicken A Review

Deepa¹,

Purushothaman²,

Vasanthakumar³

et al. 2018

Adv. Anim. Vet. Sci.

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Section: Advances In Animal and Veterinary Sciencessupporting

confidence: 76%

Butyric Acid as an Antibiotic Substitute for Broiler Chicken A Review

Deepa¹,

Purushothaman²,

Vasanthakumar³

et al. 2018

Adv. Anim. Vet. Sci.

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“…The butyrate-producing microbiota has been implicated in host health in many different disease models (35,(38)(39)(40)(41)(42)(43)(44)(45)(46)(47), resulting in increased interest in studying this community. It is therefore important to have a reliable tool to identify butyrate-producing microbes and to detect their activity.…”

Section: Discussionmentioning

confidence: 99%

Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine

Trachsel

Bayles

Looft

et al. 2016

Appl Environ Microbiol

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Studying the host-associated butyrate-producing bacterial community is important, because butyrate is essential for colonic homeostasis and gut health. Previous research has identified the butyryl coenzyme A (CoA):acetate-CoA transferase (EC 2.3.8.3) as a gene of primary importance for butyrate production in intestinal ecosystems; however, this gene family (but) remains poorly defined. We developed tools for the analysis of butyrate-producing bacteria based on 12 putative but genes identified in the genomes of nine butyrate-producing bacteria obtained from the swine intestinal tract. Functional analyses revealed that eight of these genes had strong But enzyme activity. When but paralogues were found within a genome, only one gene per genome encoded strong activity, with the exception of one strain in which no gene encoded strong But activity. Degenerate primers were designed to amplify the functional but genes and were tested by amplifying environmental but sequences from DNA and RNA extracted from swine colonic contents. The results show diverse but sequences from swine-associated butyrate-producing bacteria, most of which clustered near functionally confirmed sequences. Here, we describe tools and a framework that allow the bacterial butyrate-producing community to be profiled in the context of animal health and disease. IMPORTANCEButyrate is a compound produced by the microbiota in the intestinal tracts of animals. This compound is of critical importance for intestinal health, and yet studying its production by diverse intestinal bacteria is technically challenging. Here, we present an additional way to study the butyrate-producing community of bacteria using one degenerate primer set that selectively targets genes experimentally demonstrated to encode butyrate production. This work will enable researchers to more easily study this very important bacterial function that has implications for host health and resistance to disease. S hort-chain fatty acids (SCFAs) play a central role in the maintenance of colonic homeostasis, which is the delicate balance between the host, its immune system, and the gastrointestinal microbial partners (1). Butyrate in particular has potent effects on host tissues. As with other SCFAs, butyrate is consumed by the host as an energy source; however, unlike the other common SCFAs, such as propionate and acetate, butyrate is the preferred energy source for colonocytes (2) and is rapidly absorbed and used by the colonic epithelium. This rapid oxidation of butyrate reduces local oxygen concentrations, causing the epithelia to become hypoxic and thus limiting the growth of facultative aerobic pathogens, such as Salmonella species (3, 4). In addition, butyrate alters host gene expression to promote immune tolerance to the colonic microbiota and to improve the barrier function of the colonic epithelium. For example, butyrate has been shown to increase the secretion of antimicrobial peptides and mucus as well as the expression of tight junction proteins, thickening and strengthenin...

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“…The lack of improvement in the performance of the piglets from the antibiotic or additive treatments in this experiment may be due to rigorous sanitary control of the facilities compared with commercial conditions, which may influence the effects of these additives on animal performance (NRC, 1998;OETTING et al, 2006). Additionally, broilers which have been challenged with Salmonella Enteritidis supplemented with a specific blend of essential oil components and sodium butyrate in the feed, had no beneficial effect on growth performance (CERISUELO et al, 2014).…”

Section: Resultsmentioning

confidence: 90%